2001
DOI: 10.1161/hc4401.098293
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Abstract: Background-Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production or is influenced by adrenergic mechanisms. Methods and Results-In 12 healthy men, myocardial perfusion was measured with PET in 2 protocols performed in random order, each including 3 perfusion me… Show more

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Cited by 175 publications
(109 citation statements)
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“…A significant part of adenosine-induced vasodilation is endothelium-dependent [41]. In contrast to resting condition where flow and myocardial work (oxygen consumption) are tightly coupled, during adenosine stimulation metabolic control of myocardial blood flow is lost but endothelial and neurogenic controls are still functional.…”
Section: Myocardial Blood Flow During Normoglycaemiamentioning
confidence: 99%
“…A significant part of adenosine-induced vasodilation is endothelium-dependent [41]. In contrast to resting condition where flow and myocardial work (oxygen consumption) are tightly coupled, during adenosine stimulation metabolic control of myocardial blood flow is lost but endothelial and neurogenic controls are still functional.…”
Section: Myocardial Blood Flow During Normoglycaemiamentioning
confidence: 99%
“…15 In the present study, the coronary vasoreactivity was measured during adenosine infusion with or without simultaneous hyperinsulinemic clamp. Approximately half of the adenosine-induced vasodilation is endothelium dependent 23 and therefore adenosine is an integrating measure of endothelial function and vascular smooth muscle relaxation. In contrast to resting condition where flow and myocardial work (oxygen consumption) are tightly coupled, during adenosine stimulation, metabolic control of myocardial blood flow is lost but endothelial and neurogenic controls are still functional.…”
Section: Discussionmentioning
confidence: 99%
“…We used two different vasodilators, adenosine and insulin. The coronary vascular resistance response induced by adenosine reflects a combined effect of endothelium-dependent and -independent vasodilation, 23 whereas insulin induces and enhances vasodilation mainly via the endothelium-dependent mechanism. 24,25 Coronary vascular resistance was measured before and after dx treatment at the baseline and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp using PET and oxygen-15-labelled water ([ 15 …”
Section: Introductionmentioning
confidence: 99%
“…A detailed description of the perfusion quantization has been previously published. 21,22 MP was measured at rest and after intravenous infusion of dipyridamole (0.56 mg/kg) over 4 minutes. Image acquisition commenced 8 minutes after starting the dipyridamole infusion.…”
Section: Measurement Of Mpmentioning
confidence: 99%
“…We have previously shown that myocardial vasodilation to adenosine is partly dependent on endothelial function because it is attenuated by inhibition of nitric oxide synthase. 22 Thus, dipyridamoleinduced hyperemia is partly dependent on an intact endothelial function, and endothelial dysfunction may attenuate vasodilation irrespective of any structural vascular changes. Furthermore, ␣-adrenergic receptors are present in the coronary microcirculation and increased activity of the sympathetic nervous system, induced by generalized dipyridamoleinduced vasodilation, may lead to opposing vasoconstriction.…”
Section: Study Limitationsmentioning
confidence: 99%