Influence of morphine- or apomorphine-induced sensitization on histamine state-dependent learning in the step-down passive avoidance test

Zarrindast, Mohammad‐Reza; Khalilzadeh, Azita; Malekmohammadi, Nazanin; Fazli-Tabaei, Soheila

doi:10.1016/j.bbr.2006.03.015

Cited by 25 publications

(12 citation statements)

References 37 publications

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“…Zarrindast et al recently reported that histamine interacts with opioidergic systems in learning and memory [15] . Histamine reverses the impairment of rat memory recall induced by pretraining administration of morphine, as evaluated by the passive avoidance response [16,17] .…”

Section: Introductionmentioning

confidence: 99%

Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice

et al. 2010

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Aim: Histamine plays an important role in morphine addiction and memory-dependent behavior. However, little is known about the effect of histamine on the impairment of memory after morphine withdrawal. This study was designed to investigate the effect of histamine on memory impairment induced by morphine withdrawal in histidine decarboxylase knockout (HDC-KO) and wild-type (WT) mice. Methods: WT and HDC-KO mice were given subcutaneous morphine or saline twice daily for 5 consecutive days. The mice received a cued or contextual fear conditioning session 7 days after the last injection. During subsequent days, mice received 4 cued or contextual extinction sessions (one session per day). Western blot was used to assess extracellular signal-regulated kinase (ERK) phosphorylation in the amygdala and hippocampus. Results: Morphine withdrawal did not affect the acquisition of cued or contextual fear responses. It impaired cued but not contextual fear extinction. The acquisition of cued and contextual fear responses was accelerated in HDC-KO mice. Histamine deficiency aggravated the impairment of cued fear extinction induced by morphine withdrawal, whereas histamine (icv, 5 µg/mouse) reversed this effect. Morphine withdrawal decreased ERK phosphorylation in the amygdala after cued fear extinction, especially in HDC-KO mice. Conclusion: These results suggest that morphine withdrawal specifically impairs cued fear extinction and histamine ameliorates this impairment. Its action might be mediated by the modulation of ERK phosphorylation in the amygdala. Histamine should be explored for possible roles in the prevention or treatment of morphine abuse and relapse.

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Section: Introductionmentioning

confidence: 99%

Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice

et al. 2010

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“…route for 3 consecutive days followed by 5 days of no drug treatment. We have used this schedule of repeated administration for some other drugs such as morphine and dopamine receptor agents, and we have shown changes in expression of the receptor mRNA in the brain, suggesting sensitization [28,29] . Lithium was administered intraperitoneally (i.p.)…”

Section: Drugs and Intracerebroventricular Injectionsmentioning

confidence: 99%

“…Morphine-induced sensitization may be due to an increase in dopamine D2 receptor expression [28] . We have also reported that repeated administration of the dopamine receptor agonist apomorphine induced sensitization through dopamine D2 receptors on histamine state-dependent learning in a step-down inhibitory avoidance task [29] . Recently we have reported that lithium and histamine can induce state-dependent retrieval by themselves and a cross state-dependency between lithium and histamine was also observed [30] .…”

mentioning

confidence: 99%

Repeated Administration of Histamine Improves Memory Retrieval of Inhibitory Avoidance by Lithium in Mice

Zarrindast¹,

Parsaei

Ahmadi

2007

Pharmacology

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The influence of repeated administration of histamine on lithium-induced state dependency has been investigated. A single-trial step-down inhibitory avoidance task was used to assess memory in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg), immediately after training (post-training), impaired inhibitory avoidance memory on the test day. Pre-test administration of lithium reversed amnesia induced by the drug given after training, with the maximum response at a dose of 10 mg/kg. Repeated intracerebroventricular (i.c.v.) administration of histamine (20 µg/mouse) for 3 consecutive days followed by 5 days of no drug treatment improved memory retrieval of inhibitory avoidance by a pre-test lower dose (5 mg/kg i.p.) of lithium. In contrast, 3 days of i.c.v. injections of both the histamine H1 receptor antagonist pyrilamine (40 µg/mouse) and the histamine H2 receptor antagonist ranitidine (6.25 and 12.5 µg/mouse) prevented the improving effect of pre-test lithium (10 mg/kg i.p.) on memory retrieval. The results suggest that the repeated administration of histaminergic agents may induce a sensitization which affects the memory impairment induced by lithium.

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“…In contrast, it has been reported that histamine has suppressive effects on learning and memory. For example, Zarrindast et al (24) showed that pre-training intracerebroventricular administration of histamine decreased the learning of a one-trial passive avoidance task. On the other hand, it was found that HDC-KO female mice showed impairments in water maze performance, but enhanced passive avoidance memory retention (25).…”

Section: Discussionmentioning

confidence: 99%

Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance

et al. 2007

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Abstract. We investigated the participation of γ-aminobutyric acid (GABA) neurons of the medial septal area in eight-arm radial maze performance in rats. The intra-septal injection of muscimol, a GABA A agonist, caused an increase in total error and working memory error. On the other hand, no significant effect was observed with reference memory error. Donepezil and tacrine (cholinesterase inhibitors) antagonized the muscimol-induced spatial memory deficits. Histidine (1500 mg / kg, i.p.) also improved the total error and working memory error induced by muscimol. At this dose, histidine caused a significant increase in the histamine content of the cortex, hippocampus, and hypothalamus in rats. In addition, the intra-hippocampal injection of histamine also antagonized muscimol-induced spatial memory deficits. The practical conclusion is that the GABA A receptor of the medial septal area plays an important role in working memory, and also, the disturbance of working memory induced by muscimol is mediated not only by cholinergic but also by histaminergic systems in the spatial memory of rats.

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Influence of morphine- or apomorphine-induced sensitization on histamine state-dependent learning in the step-down passive avoidance test

Cited by 25 publications

References 37 publications

Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice

Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice

Repeated Administration of Histamine Improves Memory Retrieval of Inhibitory Avoidance by Lithium in Mice

Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance

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