Influence of monooxygenase inducers on the metabolic profile of phenanthrene in rat liver microsomes

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

“…4. These findings were not unexpected in view of metabolism studies of phenanthrene and pyrene performed in vitro with liver microsomes from rats treated with model inducers of different types (Jacob et al 1982a(Jacob et al , 1982bKandaswami et al 1988;Nordqvist et al 1981;Luukkanen et al 1997;Weems et al 1986). bNF-mediated induction seemed to influence the urinary disposition of naphthalene less than that of phenanthrene or pyrene.…”

“…This compound appeared-in the light of earlier studies (Jacob et al 1982a(Jacob et al , 1982b-as an appropriate model inducer for studying possible intraindividual differences in the metabolism of phenanthrene and pyrene. Full clearance of the first PAH dose given 6 days before the second dose was certain according to the data available on the toxicokinetics and tissue half-lives of naphthalene, phenanthrene, and pyrene in the rat (Bakke et al 1985;Corner and Young 1954;Kilanowicz et al 1999;Turkall et al 1994;Viau et al 1999).…”

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

“…4. These findings were not unexpected in view of metabolism studies of phenanthrene and pyrene performed in vitro with liver microsomes from rats treated with model inducers of different types (Jacob et al 1982a(Jacob et al , 1982bKandaswami et al 1988;Nordqvist et al 1981;Luukkanen et al 1997;Weems et al 1986). bNF-mediated induction seemed to influence the urinary disposition of naphthalene less than that of phenanthrene or pyrene.…”

“…This compound appeared-in the light of earlier studies (Jacob et al 1982a(Jacob et al , 1982b-as an appropriate model inducer for studying possible intraindividual differences in the metabolism of phenanthrene and pyrene. Full clearance of the first PAH dose given 6 days before the second dose was certain according to the data available on the toxicokinetics and tissue half-lives of naphthalene, phenanthrene, and pyrene in the rat (Bakke et al 1985;Corner and Young 1954;Kilanowicz et al 1999;Turkall et al 1994;Viau et al 1999).…”

The Significance of Polycyclic Aromatic Hydrocarbons as Environmental Carcinogens. 35 Years Research on Pah—a Retrospective

“……”

In Vitro Mammalian Mutagenicity of Complex Polycyclic Aromatic Hydrocarbon Mixtures in Contaminated Soils

“…It seems likely that both mutagenic and nonmutagenic PAHs in the complex PAH-containing fraction compete for access to CYP isozymes. In fact, many nonmutagenic PAHs, such as phenanthrene and naphthalene are known P450 substrates, , and several PAHs have been shown to inhibit the activity of human CYP1A1, 1A2 and 1B1 . Moreover, some studies have shown that the presence of nonmutagenic PAHs in a mixture with mutagenic PAHs, such as BaP, reduces mutagenic activity.…”

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

“…4. These findings were not unexpected in view of metabolism studies of phenanthrene and pyrene performed in vitro with liver microsomes from rats treated with model inducers of different types (Jacob et al 1982a(Jacob et al , 1982bKandaswami et al 1988;Nordqvist et al 1981;Luukkanen et al 1997;Weems et al 1986). bNF-mediated induction seemed to influence the urinary disposition of naphthalene less than that of phenanthrene or pyrene.…”

“…This compound appeared-in the light of earlier studies (Jacob et al 1982a(Jacob et al , 1982b-as an appropriate model inducer for studying possible intraindividual differences in the metabolism of phenanthrene and pyrene. Full clearance of the first PAH dose given 6 days before the second dose was certain according to the data available on the toxicokinetics and tissue half-lives of naphthalene, phenanthrene, and pyrene in the rat (Bakke et al 1985;Corner and Young 1954;Kilanowicz et al 1999;Turkall et al 1994;Viau et al 1999).…”

The Significance of Polycyclic Aromatic Hydrocarbons as Environmental Carcinogens. 35 Years Research on Pah—a Retrospective

“……”

In Vitro Mammalian Mutagenicity of Complex Polycyclic Aromatic Hydrocarbon Mixtures in Contaminated Soils

“…It seems likely that both mutagenic and nonmutagenic PAHs in the complex PAH-containing fraction compete for access to CYP isozymes. In fact, many nonmutagenic PAHs, such as phenanthrene and naphthalene are known P450 substrates, , and several PAHs have been shown to inhibit the activity of human CYP1A1, 1A2 and 1B1 . Moreover, some studies have shown that the presence of nonmutagenic PAHs in a mixture with mutagenic PAHs, such as BaP, reduces mutagenic activity.…”

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

“…4. These findings were not unexpected in view of metabolism studies of phenanthrene and pyrene performed in vitro with liver microsomes from rats treated with model inducers of different types (Jacob et al 1982a(Jacob et al , 1982bKandaswami et al 1988;Nordqvist et al 1981;Luukkanen et al 1997;Weems et al 1986). bNF-mediated induction seemed to influence the urinary disposition of naphthalene less than that of phenanthrene or pyrene.…”

“…This compound appeared-in the light of earlier studies (Jacob et al 1982a(Jacob et al , 1982b-as an appropriate model inducer for studying possible intraindividual differences in the metabolism of phenanthrene and pyrene. Full clearance of the first PAH dose given 6 days before the second dose was certain according to the data available on the toxicokinetics and tissue half-lives of naphthalene, phenanthrene, and pyrene in the rat (Bakke et al 1985;Corner and Young 1954;Kilanowicz et al 1999;Turkall et al 1994;Viau et al 1999).…”

The Significance of Polycyclic Aromatic Hydrocarbons as Environmental Carcinogens. 35 Years Research on Pah—a Retrospective

“……”

In Vitro Mammalian Mutagenicity of Complex Polycyclic Aromatic Hydrocarbon Mixtures in Contaminated Soils

“…It seems likely that both mutagenic and nonmutagenic PAHs in the complex PAH-containing fraction compete for access to CYP isozymes. In fact, many nonmutagenic PAHs, such as phenanthrene and naphthalene are known P450 substrates, , and several PAHs have been shown to inhibit the activity of human CYP1A1, 1A2 and 1B1 . Moreover, some studies have shown that the presence of nonmutagenic PAHs in a mixture with mutagenic PAHs, such as BaP, reduces mutagenic activity.…”