Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population

Makita, Shinji; Onoda, Toshiyuki; Ohsawa, Masaki; Tanaka, Fumitaka; Segawa, Toshie; Takahashi, Tomohiro; Satoh, Kenyu; Itai, Kazuyoshi; Tanno, Kozo; Sakata, Kiyomi; Omama, Shinichi; Yoshida, Yuki; Ishibashi, Yutaka; Koyama, Tomiko; Kuribayashi, Toru; Ogasawara, Kuniaki; Okayama, Akira; Nakamura, Motoyuki

doi:10.1016/j.atherosclerosis.2012.07.004

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…Binary logistic regression was used to examine the association between PP (independent variable) and cognitive decline (dependent variable). To examine the presence of a U‐shaped association (nonlinear) between PP with cognitive decline, PP was categorized into quartiles and entered the model as a categorical variable . Cognitive decline was indexed by CDR and MMSE changes, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…To examine the presence of a U-shaped association (nonlinear) between PP with cognitive decline, PP was categorized into quartiles and entered the model as a categorical variable. [19][20][21] Cognitive decline was indexed by CDR and MMSE changes, respectively. Putative confounding factors, including baseline age, sex, education, DM, hyperlipidemia, smoking, alcohol, AF or CHF, recurrent stroke, VBR, MTLA, lacunes, 22 antihypertensive therapy on discharge, and admission NIHSS score were first examined in a series of exploratory univariable models, and only variables with P<.10 in univariable models were then entered into multivariate regression models.…”

Section: Statisticsmentioning

confidence: 99%

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Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes

Wang

Wong

Liu

et al. 2015

J of Clinical Hypertension

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The authors hypothesized that both high and low pulse pressure (PP) may predict cognitive decline in stroke/ transient ischemic attack (TIA) patients with white matter changes (WMCs). The authors prospectively followed up 406 ischemic stroke/TIA patients with confluent WMCs over 18 months. PP was measured at 3 to 6 months after stroke/ TIA and categorized into four groups by quartile. Cognition was assessed 3 to 6 months and 15 to 18 months after stroke/TIA using the Clinical Dementia Rating and MiniMental State Examination (MMSE). Logistic regression showed that patients in the first quartile of PP had a 5.9-fold higher risk for developing cognitive decline than patients in the third quartile (odds ratio, 5.9; 95% confidence interval, 1.7-20.6), while patients in the fourth quartile had a 3.5-fold higher risk for cognitive decline than those in the third quartile (odds ratio, 3.5; 95% confidence interval, 1.0-12.4). This U-shaped relationship was also evident between PP and cognitive decline in MMSE, underlining the role of arterial stiffness and hypoperfusion in cognitive decline related to small vessel disease. J Clin Hypertens (Greenwich). 2015;17:694-698. ª 2015 Wiley Periodicals, Inc.Presence of white matter changes (WMCs) significantly increases future risk of cognitive decline. Our recent study showed that among patients with WMC, one third experienced cognitive decline and one fifth developed incident dementia over a 2-year period despite optimal control of traditional vascular risk factors.1 Mechanisms explaining cognitive decline associated with WMCs are not fully understood and are probably complex. Studies suggest that progressing WMCs and related brain atrophy play an important role.2 Age and high blood pressure (BP) are generally regarded as the most important risk factors for the development of WMC. However, the Rotterdam Scan Study shows that high systolic BP or diastolic BP accounts mainly for the initial evolution of WMCs, and association between systolic or diastolic BP increase and WMC progression becomes insignificant in those with severe WMCs at baseline. 3 Other factors may explain WMC progression and/or the related cognitive decline in patients with severe WMCs.A recent cross-sectional study shows that among healthy elderly individuals, high pulse pressure (PP; the difference between systolic BP and diastolic BP) is associated with severe WMCs independent of individual BP levels. 4 High PP in older people is a marker of increased large artery stiffness and widespread atherosclerosis. 5,6 PP may also be related to cognitive functions. A longitudinal study showed that both high and low levels of PP were predictive of incident dementia among dementia/stroke-free patients.7 Poor cerebral perfusion associated with reduced cardiac output as indexed by low PP may account for the association between low PP and increased risk of dementia. [7][8][9] It is therefore biologically plausible to hypothesize that extremes of PP may predict cognitive decline in patients with WMC as well. In the present s...

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Section: Methodsmentioning

confidence: 99%

Section: Statisticsmentioning

confidence: 99%

Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes

Wang

Wong

Liu

et al. 2015

J of Clinical Hypertension

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“…Alcohol consumption in moderation may offer protection against cardiovascular events, [1,2] but excessive alcohol intake may lead to cardiovascular diseases. [3,4] Chronic alcohol abuse can cause many toxic and metabolic disorders, [1,5] abnormalities in calcium homeostasis, [6] and increases norepinephrine, [7] which progressively lead to myocyte and cardiac dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Assessment of left ventricular function in chronic alcoholics by real-time three-dimensional echocardiography

et al. 2017

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Chronic alcohol consumption may lead to progressive cardiac dysfunction. The aim of this study was to evaluate the feasibility of using real-time 3-dimensional echocardiography (3DE) on assessing left ventricular (LV) function in chronic alcoholics.We classified 92 male alcoholics into mild, moderate, and severe groups; 30 age-matched controls were also recruited. LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), LV mass (LVM), LV mass index (LVMI), and systolic dyssynchrony index (SDI) were measured by 3DE and 2-dimensional echocardiography (2DE).Compared to the control group, LV volume and mass were higher in the moderate and severe alcoholic groups (P < 0.05). The severe alcoholic (symptomatic) group demonstrated decreased LVEF and increased SDI (detected by 3DE) (P < 0.05).Real-time 3DE can detect the increases of LV volumes and mass in asymptomatic alcoholics, and the changes of LVEF and systolic synchrony index in symptomatic alcoholics.

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“…About 80 percent of strokes are the result of a blood clot preventing blood flow to the brain. 22 These are termed ischemic strokes. Another reason for a stroke is blood accumulating in the brain or in the spaces surrounding the brain and these are termed hemorrhagic strokes.…”

Section: Strokesmentioning

confidence: 99%

“…Another reason for a stroke is blood accumulating in the brain or in the spaces surrounding the brain and these are termed hemorrhagic strokes. 22 Clinicians attribute binge drinking or long-term heavy drinking to strokes regardless of a history of coronary heart disease. 23 Recent studies show that those who binge drink are 56% more likely than persons who never binge drink to experience an ischemic stroke.…”

Section: Strokesmentioning

confidence: 99%

The Pathology of Alcohol Use and Abuse

Montoya

2013

Clin Lab Sci

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Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population

Cited by 13 publications

References 25 publications

Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes

Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes

Assessment of left ventricular function in chronic alcoholics by real-time three-dimensional echocardiography

The Pathology of Alcohol Use and Abuse

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