Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers

Tanaka, Makoto; Satô, Masayoshi; Umehara, Shino; Nishikawa, Toshiaki

doi:10.1152/ajpregu.00162.2003

Cited by 74 publications

(90 citation statements)

References 30 publications

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“…Also, the augmented heart rate and sympathetic nerve responses in men could be the result of greater integrated baroreceptor unloading, as suggested by the larger drop in stroke volume. Nonetheless, the current data support earlier conclusions about attenuated cardiovagal baroreflex gain (1,38) and reduced heart rate responses to carotid baroreceptor stimulation (7) in women vs. men. Although cardiovagal and sympathetic baroreflex control may be affected by menstrual cycle (8,28), it is unclear whether this effect can overwhelm the overall difference between male and female orthostatic responses (36).…”

Section: Discussionsupporting

confidence: 91%

Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading

Kimmerly¹,

Wong²,

Menon³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Kimmerly DS, Wong S, Menon R, Shoemaker JK. Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading. Am J Physiol Regul Integr Comp Physiol 292: R715-R722, 2007. First published July 6, 2006; doi:10.1152/ajpregu.00366.2006-Generally, women demonstrate smaller autonomic and cardiovascular reactions to stress, compared with men. The mechanism of this sex-dependent difference is unknown, although reduced baroreflex sensitivity may be involved. Recently, we identified a cortical network associated with autonomic cardiovascular responses to baroreceptor unloading in men. The current investigation examined whether differences in the neural activity patterns within this network were related to sex-related physiological responses to lower body negative pressure (LBNP,5,15, and 35 mmHg). Forebrain activity in healthy men and women (n ϭ 8 each) was measured using functional magnetic resonance imaging with blood oxygen level-dependent (BOLD) contrast. Stroke volume (SV), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were collected on a separate day. Men had larger decreases in SV than women (P Ͻ 0.01) during 35 mmHg LBNP only. At 35 mmHg LBNP, HR increased more in males then females (9 Ϯ 1 beats/min vs. 4 Ϯ 1 beats/min, P Ͻ 0.05). Compared with women, increases in total MSNA were similar at 15 mmHg LBNP but greater during 35 mmHg LBNP in men [1,067 Ϯ 123 vs. 658 Ϯ 103 arbitrary units (au), P Ͻ 0.05]. BOLD signal changes (P Ͻ 0.005, uncorrected) were identified within discrete forebrain regions associated with these sex-specific HR and MSNA responses. Men had larger increases in BOLD signal within the right insula and dorsal anterior cingulate cortex than women. Furthermore, men demonstrated greater BOLD signal reductions in the right amygdala, left insula, ventral anterior cingulate, and ventral medial prefrontal cortex vs. women. The greater changes in forebrain activity in men vs. women may have contributed to the elevated HR and sympathetic responses observed in men during 35 mmHg LBNP. autonomic nervous system; baroreflex; microneurography; functional neuroimaging THE PHYSIOLOGICAL RESPONSES to a reduction in central blood volume involve baroreflex-mediated increases in heart rate (HR) and vascular resistance to adequately maintain arterial pressure and cerebral perfusion. Compared with men, reduced orthostatic tolerance has been observed in women (7,18), and this has been associated with differential (14, 36) autonomic and cardiovascular responses to baroreceptor unloading. In general, women respond to an orthostatic challenge with a greater HR increase, whereas men have larger increases in sympathetic vasoconstrictor activity and vascular resistance. The underlying mechanisms responsible for these varied responses are unclear but may be influenced by differences in the central processing and modulation of baroreceptor afferent information.Although the medulla oblongata remains the primary regulatory site of cardiovascular functi...

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Section: Discussionsupporting

confidence: 91%

Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading

Kimmerly¹,

Wong²,

Menon³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Greenberg et al 11 , Hirshoren et al 12 and Pai et al 13 also have demonstrated similar findings. Again, sato et al 1 observed similar results when compared SBP and DBP during follicular and luteal phases of menstrual cycle.…”

Section: Discussionmentioning

confidence: 61%

Sympathetic nerve function status and their relationships with ovarian hormones in healthy young women

Naher

Begum

Ferdousi

2016

J Bangladesh Soc Physiol

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Background: Alteration of sympathetic nerve activity during different phases of menstrual cycle in healthy young women, has been found related with phasic fluctuation of ovarian hormones. Objective: To observe relation of sympathetic nerve function status with estrogen and progesterone during follicular and luteal phases of menstrual cycle in healthy young women. Methods: This cross sectional study was carried out in the Department of physiology of BSMMU, Dhaka from 1 st January to 31 st December 2007. Thirty apparently healthy unmarried women with age 20 to 30 years were selected. Sympathetic nerve function was evaluated by 2 reflex tests, orthostatic test and sustained handgrip, during the three phases of menstrual cycle. Serum estrogen and progesterone were measured during follicular and luteal phases. Data were analyzed by One way ANOVA, an unpaired t test and Pearson's correlation coefficient where applicable. Results: There were no significant significant differences among sympathetic nerve function parameters during three phases of menstrual cycle. Serum estrogen and progesterone showed non significant (p>0.05) relationship with sympathetic nerve function parameters. Conclusion: From this study it may be concluded that sympathetic nerve activity remains unaltered despite fluctuation of ovarian hormones in different phases of menstrual cycle in healthy young women.

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“…Significant correlations were observed between plasma estradiol concentrations and BRS assessed by the phenylephrine method and the Valsalva maneuver. 24 Sevre et al demonstrated a significantly lower BRS in hypertensive subjects than in normotensive controls. 15 Moreover, the reduction in BRS was most pronounced in the female group and did not reach statistical significance in men.…”

Section: Discussionmentioning

confidence: 93%

“…Similarly, it has been previously reported that baroreflex-mediated control of heart rate is altered during the normal menstrual cycle. 24 The baroreflex-mediated bradycardic response was augmented during the preovulatory phase and appeared to correlate with the plasma estradiol concentration, whereas baroreflex-mediated tachycardia was augmented during the early follicular phase. Significant correlations were observed between plasma estradiol concentrations and BRS assessed by the phenylephrine method and the Valsalva maneuver.…”

Section: Discussionmentioning

confidence: 95%

Gender Difference in Baroreflex Sensitivity to Predict Cardiac and Cerebrovascular Events in Type 2 Diabetic Patients

Yufu

Takahashi

Okada

et al. 2011

Circ J

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Background: Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM), and baroreflex sensitivity (BRS) reportedly can predict cardiovascular prognosis in type 2 DM patients. The hypothesis that cardiovascular events are associated with gender differences in BRS was tested in the present study. Methods and Results:From 1998, we have evaluated BRS by phenylephrine methods in 185 consecutive type 2 DM patients. The long-term prognostic value of BRS was compared between 91 female (58±12 years) and 94 male patients (58±11 years). There was no significant difference in age or severity and duration of DM between the 2 groups. When compared to male, the BRS value in female patients was significantly lower (9.26±6.0 vs. 5.97±5.0 ms/mmHg, P<0.0001). During a mean of 62.7 months of follow-up, 16 female patients developed cardiovascular events (17.6%) including stroke, acute myocardial infarction, angina pectoris requiring percutaneous coronary intervention or coronary artery bypass grafting and congestive heart failure requiring admission, while only 4 male patients developed events (4.3%, P<0.005). In females, the Kaplan-Meier curves revealed that those with depressed BRS (<6 ms/mmHg) had a higher incidence of cardiovascular events than those with preserved BRS (P<0.05), but this relationship was not observed in male patients. Conclusions:Although the reason why females had a more depressed BRS remains unclear, our findings demonstrated that a depressed BRS value can accurately predict cardiovascular events, especially in female patients with type 2 DM. (Circ J 2011; 75: 1418 - 1423

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Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers

Cited by 74 publications

References 30 publications

Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading

Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading

Sympathetic nerve function status and their relationships with ovarian hormones in healthy young women

Gender Difference in Baroreflex Sensitivity to Predict Cardiac and Cerebrovascular Events in Type 2 Diabetic Patients

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