Influence of meclofenamic acid on the initiation of parturition and lactation in the sow

Gooneratne, A. D.; Hartmann, PE; Barker, Ian K.

doi:10.1530/jrf.0.0650157

Cited by 7 publications

(10 citation statements)

References 16 publications

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“…The first stage is characterized by a decline in the concentration of plasma progesterone from 7 days pre partum (Text-figs 1 & 2); this decline in progesterone continued during meclofenamic acid treatment (Text- fig. 1; Gooneratne et al, 1982). By 2 days pre partum relaxin was released into the peripheral circulation (stage 2) and this was also observed in meclofenamic acid-treated sows (Text-figs 1 and 2).…”

Section: Resultsmentioning

confidence: 75%

“…Nara & First (1981) concluded that PGF-2a was the natural luteolytic agent at parturition in the sow. However, the findings from studies using meclofenamic acid, a potent PG synthesis inhibitor (Flower, 1974), are consistent with a two-phase luteolysis in the sow-the first being independent of PG, the second requiring large amounts of PG (Gooneratne et al, 1982). There is, in addition, no conclusive evidence in the pre-partum sow, that a rise in plasma concentrations of PG occurs before the changes in plasma progesterone or relaxin.…”

Section: Introductionmentioning

confidence: 91%

“…PG concentrations remain low in the maternal circulation until the day of parturition when both PGF-2oc (Silver et al, 1979) and its metabolite 13,14 dihydro-15-keto-PGF-2a (PGFM) (Silver et al, 1979;First & Bosc, 1979; Liptrap, 1980;Nara & First, 1981) increase 10-20-fold. The administration of PGF-2a to late pregnant gilts and sows induces parturition within 30 h (see First & Bosc, 1979), and administration of PG synthesis inhibitors delays the onset of parturition in the sow (Nara & First, 1981 ; Gooneratne, Hartmann & Barker, 1982) until withdrawal of treatment. Nara & First (1981) concluded that PGF-2a was the natural luteolytic agent at parturition in the sow.…”

Section: Introductionmentioning

confidence: 99%

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Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Gooneratne¹,

Bryant‐Greenwood²,

Walker³

et al. 1983

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Summary. The pre-partum plasma concentrations of progesterone, relaxin, PGF\x=req-\ 2\g=a\and 13,14-dihydro-15-keto PGF-2\g=a\(PGFM) were determined in 6 sows treated with meclofenamic acid (5\m=.\0mg/kg body wt daily, from Day 109 to Day 113 of pregnancy), and 2 sows which farrowed prematurely. The inhibition of PG synthesis with meclofenamic acid did not prevent either the decline in plasma progesterone or the release of relaxin. Three distinct stages in the progressive changes of the above hormones were apparent before parturition: (1) the gradual decline in the concentrations of progesterone from about 7 days pre partum to reach <4\m=.\5 ng/ml at farrowing; (2) a surge in relaxin levels (>100 ng/ml) by 2 daysprepartum; and (3) sharp increases in the concentrations of PGF-2\g=a\and PGFM within 24 h of parturition. Maximal concentrations of PGF-2\g=a\(>0\m=.\5 ng/ml) and PGFM (>20\m=.\0 ng/ml) occurred during farrowing. It is suggested that PG from an extra-ovarian source may not be responsible for initiating functional regression of the corpora lutea in the sow.

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Section: Resultsmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Gooneratne¹,

Bryant‐Greenwood²,

Walker³

et al. 1983

Reproduction

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“…Relaxin levels abruptly decrease one day before expulsion of the fetuses, whereas oxytocin concentrations peak before and during farrowing (ELLENDORFF et al, 1979). PGF is essential for parturition and its exogenous administration induces a rapid decline in progesterone levels (TAVERNE et al, 1979), whereas its blockade delays farrowing (GOONERATNE et al, 1982).…”

Section: Physiology Of Gestation and Parturition In Swinementioning

confidence: 99%

“…Initially, intramuscular (i.m.) injections of progesterone (SHERWOOD et al, 1978;GOONERATNE et al, 1979) or treatment with prostaglandin synthesis inhibitors to prevent luteolysis were evaluated (GOONERATNE et al, 1982). The possibility of using oral progestagen supplementation using MPA (KIRKWOOD et al, 1985;GUTHRIE et al, 1987;WHITELY et al, 1990) was also examined.…”

Section: Managing the Parturition Time Using Progestagen Supplementationmentioning

confidence: 99%

Prepartum progestagen supplementation in swine: a strategy to facilitate piglet care and prevent early parturition

et al. 2017

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Gestation length in swine has a considerable amplitude and both early and delayed parturition are common. This variation increases the occurrence of unassisted farrowing and could lead to a wide-ranging age at weaning for piglets born from one batch. Supervision of sow parturition is crucial to reduce mortality of neonate piglets. To facilitate assistance, induction of farrowing using prostaglandin F2α (PGF) has been widely used in batch farrowing systems, whereby synchronization would concentrate the time of farrowing, allowing for better organization of employees. However, a viable alternative method that can be implemented to manage farrowing is to sustain high progestagen levels in the final days of gestation and, consequently, prevent early parturition. Efficient techniques to delay farrowing such as using oral progestagen supplementation have been previously described, but are only recently being considered for commercial use. The present manuscript reviews publications regarding delaying parturition and discusses the use of intravaginal devices (IVDs) containing progestagen. There is limited data addressing the effect of progestagen treatment during gestation on productive and reproductive performance. Therefore, future studies should focus on improving synchronization protocols following progestagen supplementation and evaluating piglet viability and sow fertility, before widely using progestagen supplementation to manipulate parturition.

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Interrelationships between endocrine changes in peripheral and uterine-venous blood and uterine activity at parturition in the pig

Randall¹,

Taverne²,

Challis³

et al. 1986

Animal Reproduction Science

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Influence of meclofenamic acid on the initiation of parturition and lactation in the sow

Cited by 7 publications

References 16 publications

Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Prepartum progestagen supplementation in swine: a strategy to facilitate piglet care and prevent early parturition

Interrelationships between endocrine changes in peripheral and uterine-venous blood and uterine activity at parturition in the pig

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