Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Müller, Stefan A.; Treutner, K.‐H.; Tietze, L.; Anurov, M.; Titkova, S.; Polivoda, M. D.; Oettinger, A. P.; Schumpelick, Volker

doi:10.1007/s004230100212

Cited by 25 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in accordance with our previous findings [10]. In another study, we could demonstrate that even a dosage of 120 mg/kg had no detrimental effect on anastomotic bursting pressure, tensile strength of laparotomy wounds, and healing of liver incisions [11].…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Effects of Intra-Abdominal Drainages on Adhesion Formation and Prevention by Phospholipids in a Rat Model

Bertram¹,

Treutner²,

Tietze³

et al. 2003

Eur Surg Res

View full text Add to dashboard Cite

Background and Aims: The study was designed to asses the adhesiogenic capacity of silicone drainages and the protective effect of phospholipids (PL). Materials and Methods: A total of 75 Wistar rats were randomly assigned to the different groups. In a preliminary trial (pt; n = 15), all rats underwent midline laparotomy. The control group (C_pt; n = 5) received no further treatment. In the other animals, either an ‘easy flow’ drainage (EF_pt; n = 5) or an ‘Aachen’ drainage (AC_pt; n = 5) was placed into the abdominal cavity. In the final study (fs; n = 60), rats underwent laparotomy and colonic anastomosis. The control groups (C_fs) received no drainages. In the other groups either one of the two types of drainages (EF_fs, AC_fs) were introduced. In 50% of the rats, 75 mg/kg of PL were administered intraperitoneally (C_fs+PL, EF_fs+PL, AC_fs+PL). The other rats received no additional treatment (C_fsØPL, EF_fsØPL, AC_fsØPL). All animals were sacrificed 10 days after surgery. Areas of adhesions and anastomotic bursting pressures were measured (mean ± SD). Results: In the preliminary trial, analysis of variance (ANOVA) revealed no differences between the groups after application of drainages (values are given in mean ± SD): C_pt mean 23.3 ± 29.4 mm², EF_pt 829.7 ± 679.3 mm², AC_pt 609.9 ± 219.4 mm². In the final study, 2-factorial ANOVA showed a significant effect (p < 0.001) for the use of drainages but not for the application of PL (C_fsØPL 140.6 ± 124.2 mm², C_fs+PL 67.7 ± 60.4 mm², EF_fsØPL 1,217.0 ± 458.3 mm², EF_fs+PL 1,266.8 ± 368.3 mm², AC_fsØPL 861.7 ± 274.8 mm², AC_fs+PL 544.2 ± 193.8 mm²). Post hoc test for pairwise comparisons adjusted to Bonferroni showed significant differences (p < 0.001) between all of the three pairs (C_fs 104.1 ± 92.3 mm² vs. EF_fs 1,241.9 mm² ± 413.3 mm²; C_fs vs. AC_fs 702.9 mm ± 234.3 mm²; EF_fs vs. AC_fs). Discussion: The final study demonstrates the adhesiogenic capacity of silicone drainage tubes in combination with anastomoses. Any protective effect of PL alone or in combination with drainages could not be shown. Conclusions: Indication for the use of drainages in standard surgical procedures should be reconsidered within the scope of their potential to cause adhesions and subsequent complications.

show abstract

Section: Discussionsupporting

confidence: 81%

“…This prompted our study on the potential adhesiogenic effect of standard silicone drainage tubes. Additionally, we wanted to evaluate the efficacy of phospholipids (PL), which proved their benefit in previous trials [10][11][12], concerning prevention of adhesions in this setting.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intra-Abdominal Drainages on Adhesion Formation and Prevention by Phospholipids in a Rat Model

Bertram¹,

Treutner²,

Tietze³

et al. 2003

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…or as cobweb-like tissues [22]. Although sometimes early adhesions may resolve spontaneously, frequently, they persist even over years.…”

Section: Discussionmentioning

confidence: 99%

Morphology, quality, and composition in mature human peritoneal adhesions

Binnebösel

Klinge

Rösch

et al. 2007

Langenbecks Arch Surg

Self Cite

View full text Add to dashboard Cite

The distinct composition of cellular components as well as of extracellular matrix proteins may reflect an interactive cross-talk between adhesion- and stroma-derived cells even in mature adhesions. Our findings support the hypothesis that the disabilities of appropriate repair of the peritoneal surface leading to persistent adhesions are a consequence of a permanent process of disturbed remodeling.

show abstract

“…Phospholipids have been shown to reduce adhesion formation in different settings, including that of general peritonitis. A maximal beneficial effect was achieved with a dose of only 70 mg per kg bodyweight 14,18,30 .…”

Section: Discussionmentioning

confidence: 99%

Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions

Müller

Treutner

Anurov

et al. 2003

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Influence of intraperitoneal phospholipid dosage on adhesion formation and wound healing at different intervals after surgery

Abstract: These results prove the efficacy of PLs in adhesion prevention in two concentrations. The findings reveal an unimpeded healing of anastomoses, laparotomy wounds, and liver incisions at different periods after surgery.

Cited by 25 publications

References 24 publications

Effects of Intra-Abdominal Drainages on Adhesion Formation and Prevention by Phospholipids in a Rat Model

Effects of Intra-Abdominal Drainages on Adhesion Formation and Prevention by Phospholipids in a Rat Model

Morphology, quality, and composition in mature human peritoneal adhesions

Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions

Contact Info

Product

Resources

About