Influence of IL‐6, IL‐33, and TNF‐α on human mast cell activation: Lessons from single cell analysis by flow cytometry

Cop, Nathalie; Ebo, Didier G.; Bridts, Chris H.; Elst, Jessy; Hagendorens, Margo M.; Mertens, Christel; Faber, Margaretha A.; Clerck, Luc S. De; Sabato, Vito

doi:10.1002/cyto.b.21547

Cited by 36 publications

(60 citation statements)

References 35 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to IgE‐mediated degranulation, IL‐33 has no priming effect on degranulation induced by substance P through the MRGX2 receptor . Consistent with the fact that IL‐33 primes mast cells, mice treated with anti‐IL‐33 and anti‐ST2 antibodies show reduced ear swelling in the passive cutaneous anaphylaxis model induced by FcεRI aggregation .…”

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 70%

“…IL‐33 activates mast cells, leading to secretion of cytokines and lipid mediators, and potentiates degranulation in response to FcεRI triggering . Not only does IL‐33 increase the percentage of mast cells that degranulate, but also the magnitude of degranulation at a single cell level .…”

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 99%

“…Not only does IL‐33 increase the percentage of mast cells that degranulate, but also the magnitude of degranulation at a single cell level . Antigen/IgE‐mediated degranulation is also increased by IL‐6, but to a lesser extent than by IL‐33, and combining IL‐33 and IL‐6 has a synergistic effect . IL‐33 has no effect on the calcium response elicited by FcεRI engagement, and the mechanism by which IL‐33 primes mast cells to be more prone to degranulation remains to be elucidated .…”

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 99%

“…IL-33 activates mast cells, leading to secretion of cytokines and lipid mediators, 76,77 and potentiates degranulation in response to FcεRI triggering. [77][78][79][80] Not only does IL-33 increase the percentage of mast cells that degranulate, but also the magnitude of degranulation at a single cell level. 81 Antigen/IgE-mediated degranulation is also increased by IL-6, but to a lesser extent than by IL-33, and combining IL-33 and IL-6 has a synergistic effect.…”

Section: Multifunctional Roles Of Il-33 In Mast Cell Signalingmentioning

confidence: 99%

See 3 more Smart Citations

Changing the threshold—Signals and mechanisms of mast cell priming

Hálová

Rönnberg

Dráberová

et al. 2018

Immunological Reviews

View full text Add to dashboard Cite

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4, -6 and -33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E , sphingosine-1-phosphate, and β-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.

show abstract

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 70%

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 99%

Section: Multifunctional Roles Of Il‐33 In Mast Cell Signalingmentioning

confidence: 99%

Section: Multifunctional Roles Of Il-33 In Mast Cell Signalingmentioning

confidence: 99%

See 2 more Smart Citations

Changing the threshold—Signals and mechanisms of mast cell priming

Hálová

Rönnberg

Dráberová

et al. 2018

Immunological Reviews

View full text Add to dashboard Cite

show abstract

“…12,13 This observation led to the successful use of anti-IL-6 therapy to treat mast cell-related pathologies, such as mastocytosis, associated with increased IL-6 levels. Several lines of evidence support a stimulatory role of IL-6 and IL-1β on mast cells.…”

Section: Il-6 and Il-1β Expression Is Increased In Autologous Serum Smentioning

confidence: 99%