Influence of Hyperglycaemia on Maximal Gastric Secretion in Healthy Subjects

Markiewicz, K; Lukin, M

doi:10.1159/000197926

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…It is also possible that the sen- For acid secretion, comparisons were between the series: **,P=0.004 (Mann-Whitney U-test). This contrasts to findings in mammals, where artificially increased (by parenteral administration) blood glucose levels inhibit both basal and postprandial secretion (Dotevall & Muren 1961, Kemp et al 1%8, Moore 1973, Solomon & Spiro 1959, Stacher et al 1976), though concerning pentagastric-induced secretion the results are conflicting (Holst & Christiansen 1975, Markiewicz & Lukin 1976. Table 5.…”

Section: Discussionmentioning

confidence: 89%

“…injection of glucose rendered highly hyperglycemic animals, as the glucose level was increased about 4 times, but did not affect the secretion of gastric acid. This contrasts to findings in mammals, where artificially increased (by parenteral administration) blood glucose levels inhibit both basal and postprandial secretion (Dotevall & Muren 1961, Kemp et al 1%8, Moore 1973, Solomon & Spiro 1959, Stacher et al 1976), though concerning pentagastric-induced secretion the results are conflicting (Holst & Christiansen 1975, Markiewicz & Lukin 1976. The mammalian lateral hypothalamus contains glucose-sensitive chemoreceptors (Colin-Jones & Himsworth 1970); the inhibition probably beeing mediated via these structures.…”

Section: Discussionmentioning

confidence: 91%

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Effect of vagotomy and glucose administration on gastric acid secretion in the Atlantic cod, Gadus morhua

Cederberg

1980

Acta Physiologica Scandinavica

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Cods were prepared for measurement of gastric acid secretion. Cannulae were implanted for drainage of the stomach and for separate perfusion of the stomach and intestine. Fishes, intestinally perfused with diluted sea-water (33% SW) exhibited high rates of acid secretion. This "basal" secretion was abolished (96% inhibition) by bilateral vagotomy. Perfusion of the stomach with isosmotic glucose (5.5%) diminished the amount of titratable acid in the gastric effluence, and induced oral ingestion of water. Only part of the decrease could be explained by neutralization by ingested sea-water. Perfusion of the intestine with 5.5% glucose, containing sea-water to raise the osmolality to that of 50% SW, depressed gastric acid secretion compared to 50% SW-perfused controls, without significantly affecting oral intake of water. I.m. administration of glucose, increasing plasma glucose to the same level as intraluminal administration, did not affect acid secretion or oral water ingestion. The study demonstrates the existence of a potential intestinal mechanism for inhibition of gastric acid secretion, and indicates that vagal activity is independent of the blood glucose level in the cod.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Effect of vagotomy and glucose administration on gastric acid secretion in the Atlantic cod, Gadus morhua

Cederberg

1980

Acta Physiologica Scandinavica

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“…Furthermore, gastric acid secretion is closely related to the occurrence and development of peptic ulcers. Previous research has that moderate physical activity may decrease gastric secretions in healthy individuals, thereby protecting the mucosa of the digestive tract [25,26]. However, the impact of this on populations with pre-existing ulcer lesions has yielded inconsistent results in various studies [27,28].…”

Section: Discussionmentioning

confidence: 99%

The association between peptic ulcer disease and physical activity in Wuwei cohort of northwest China: A cross-sectional study

Li,

Zheng,

Peng

et al. 2024

Preprint

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Although the incidence of peptic ulcer disease (PUD) is gradually decreasing, it is still a common upper gastrointestinal disease worldwide. The relationship between PUD and physical activities was evaluated in Wuwei cohort. Ultimately 4612 patients were included. The status of PUD was confirmed by gastroscopy and the metabolic equivalents of task (MET) scores were evaluated through questionnaires. In addition to the overall analysis, stratified regression analysis was performed based on body measurement indice and age. Female participants in moderate level group had a lower prevalence of gastric ulcer (GU) (OR: 0.58, 95% CI: 0.36, 0.93). After further adjusting, the same conclusion could still be reached (model 2 OR: 0.53, 95% CI: 0.28, 0.99). In stratified analysis based on body mass index (BMI) and waist circumference (WC), moderate physical activity was associated with a reduction in the risk of GU among females. In stratified analysis by age, participants with age < 60 in moderate and high level groups had a lower risk of GU. The prevalence of gastric ulcer in female participants with moderate physical activity was lower. In addition, females under 60 in the high level group had a lower risk of PUD.

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“…Studies on exercise and gastric acid secretion report a decrease in fasted gastric acid secretion either during exercise or during restitution [69][70][71] . Furthermore, physical stress is known to induce a 3-fold increase in fasted gastric acid secretion 72 .…”

Section: Biological Variations and Other Factors Influencing Fasted G...mentioning

confidence: 99%

Intra- and interindividual variability in fasted gastric content volume

Roelofs,

Camps,

Leenders

et al. 2024

Preprint

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Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. Analysis included 366 participants with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (SD) value of 33 mL (25 mL). The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.

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Influence of Hyperglycaemia on Maximal Gastric Secretion in Healthy Subjects

Cited by 6 publications

References 4 publications

Effect of vagotomy and glucose administration on gastric acid secretion in the Atlantic cod, Gadus morhua

Effect of vagotomy and glucose administration on gastric acid secretion in the Atlantic cod, Gadus morhua

The association between peptic ulcer disease and physical activity in Wuwei cohort of northwest China: A cross-sectional study

Intra- and interindividual variability in fasted gastric content volume

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