Influence of HMG-CoA Reductase Inhibitors on Leptin-Induced Endothelial Cell Proliferation, Migration, and Capillary-Like Tube Formation

Burgazli, Kamil Mehmet; Stein, Natalia; Mericliler, M; Parahuleva, Mariana; Erdoğan, Ali

doi:10.3810/pgm.2014.05.2771

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…Many studies have already shown the application potentials of magnesium and its alloy as biodegradable implants, such as bone fixation, cardiovascular stent, surgical staples and microclip [ [7] , [8] , [9] , [10] , [11] , [12] ]. The biofunctions of magnesium have also been proved such as stimulating bone growth, promoting angiogenesis and wound healing [ [13] , [14] , [15] ]. Wu et al found good biocompatibility and no inflammation of pure magnesium staples that were implanted in stomach of pigs for 9 weeks [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

Gao

et al. 2021

Bioactive Materials

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Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach, however they cannot be absorbed in human body, which may cause a series of complications to influence further diagnosis. Magnesium and its alloy have great potential as surgical staples, because they can be degraded in human body and have good mechanical properties and biocompatibility. In this study, Mg-2Zn-0.5Nd (ZN20) alloy fine wires showed great potential as surgical staples. The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%, respectively, which could be benefit for the deformation of the surgical staples from U-shape to B-shape. The bursting pressure of the wire was about 40 kPa, implying that it can supply sufficient mechanical support after anastomosis. Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire. The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion. The second phase had a negative influence on corrosion property due to galvanic corrosion. The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.

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Section: Introductionmentioning

confidence: 99%

The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

Gao

et al. 2021

Bioactive Materials

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Key Enzymes for the Mevalonate Pathway in the Cardiovascular System

Zhang

Jin

Wang

et al. 2021

Journal of Cardiovascular Pharmacology

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Isoprenylation is an important post-transcriptional modification of small GTPases required for their activation and function. Isoprenoids, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate, are indispensable for isoprenylation by serving as donors of a prenyl moiety to small G proteins. In the human body, isoprenoids are mainly generated by the mevalonate pathway (also known as the cholesterol-synthesis pathway). The hydroxymethylglutaryl coenzyme A reductase catalyzes the first rate-limiting steps of the mevalonate pathway, and its inhibitor (statins) are widely used as lipid-lowering agents. In addition, the FPP synthase is also of critical importance for the regulation of the isoprenoids production, for which the inhibitor is mainly used in the treatment of osteoporosis. Synthetic FPP can be further used to generate geranylgeranyl pyrophosphate and cholesterol. Recent studies suggest a role for isoprenoids in the genesis and development of cardiovascular disorders, such as pathological cardiac hypertrophy, fibrosis, endothelial dysfunction, and fibrotic responses of smooth-muscle cells. Furthermore, statins and FPP synthase inhibitors have also been applied for the management of heart failure and other cardiovascular diseases rather than their clinical use for hyperlipidemia or bone diseases. In this review, we focus on the function of several critical enzymes, including hydroxymethylglutaryl coenzyme A reductase, FPP synthase, farnesyltransferase, and geranylgeranyltransferase in the mevalonate pathway which are involved in regulating the generation of isoprenoids and isoprenylation of small GTPases, and their pathophysiological role in the cardiovascular system. Moreover, we summarize recent research into applications of statins and the FPP synthase inhibitors to treat cardiovascular diseases, rather than for their traditional indications respectively.

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Influence of HMG-CoA Reductase Inhibitors on Leptin-Induced Endothelial Cell Proliferation, Migration, and Capillary-Like Tube Formation

Abstract: Through modulation of prenylation, leptin-induced pro-atherosclerotic events including proliferation and migration were inhibited by HMG-CoA reductase inhibitors.

Cited by 2 publications

References 58 publications

The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

Key Enzymes for the Mevalonate Pathway in the Cardiovascular System

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