Influence of highly concentrated fluoride dentifrices on remineralization characteristics of enamel in vitro

Abstract

Remineralization characteristics of enamel directly depended on baseline mineral loss.

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (ΔΔZ) as well as lesion depth (ΔLD) and fluoride concentration (0-1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride's ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27,28], in situ [14,29,30], and in vitro [4,5,7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

“…While comparing numerous different experiments with similar settings [3], different methods of initial demineralization [4], or different lowly and highly cariogenic pH-cycling conditions [5], these fluoride doseresponses were observed. However, only a few studies presented data on the correlations between mineral loss and fluoride concentrations [5][6][7] and only in one of the abovementioned pH-cycling models (human or bovine) dentin has been analyzed [5]. In this study, a significant dose-response characteristic for different baseline substrate conditions and for dentifrices containing fluoride in the range 1,450-12,500 ppm (as NaF) in a lowly and highly cariogenic pH-cycling model could be revealed.…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (ΔΔZ) as well as lesion depth (ΔLD) and fluoride concentration (0-1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride's ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27,28], in situ [14,29,30], and in vitro [4,5,7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

“…While comparing numerous different experiments with similar settings [3], different methods of initial demineralization [4], or different lowly and highly cariogenic pH-cycling conditions [5], these fluoride doseresponses were observed. However, only a few studies presented data on the correlations between mineral loss and fluoride concentrations [5][6][7] and only in one of the abovementioned pH-cycling models (human or bovine) dentin has been analyzed [5]. In this study, a significant dose-response characteristic for different baseline substrate conditions and for dentifrices containing fluoride in the range 1,450-12,500 ppm (as NaF) in a lowly and highly cariogenic pH-cycling model could be revealed.…”

Biomimetic Action of Zinc Hydroxyapatite on Remineralization of Enamel and Dentin: A Review

“…These studies would seem to validate the purpose of this review, namely, to determine whether products containing zinc–carbonate hydroxyapatite can be considered a viable alternative to fluorine or other prophylactic systems in terms of remineralization. It is known based on the literature that fluoride is a remineralizing agent [ 27 , 28 , 29 ]. CCP-ACP also appears to be another valuable system [ 30 , 31 , 32 , 70 ] for reducing dental sensitivity [ 71 ].…”

Demineralisationshemmende Effekte hochfluorid- und kalziumhaltiger zahnärztlicher Lacke in Kombination mit regulär- oder hochfluoridierter Zahnpasta auf Schmelz - in vitro

“…Aus Rinderschneidezähnen wurden 300 Schmelzblöcke (5 mm x 3,5 mm x 3 mm) hergestellt. Die Schmelzblöcke wurden in Epoxidharz eingebettet, plan geschliffen und poliert [24]. Die Hälfte der Oberfläche jedes Probekörpers wurde mit Nagellack bedeckt (Gesundkontrollfläche (GF)), um eine mögliche Beschädigung (z.…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (ΔΔZ) as well as lesion depth (ΔLD) and fluoride concentration (0-1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride's ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27,28], in situ [14,29,30], and in vitro [4,5,7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

“…While comparing numerous different experiments with similar settings [3], different methods of initial demineralization [4], or different lowly and highly cariogenic pH-cycling conditions [5], these fluoride doseresponses were observed. However, only a few studies presented data on the correlations between mineral loss and fluoride concentrations [5][6][7] and only in one of the abovementioned pH-cycling models (human or bovine) dentin has been analyzed [5]. In this study, a significant dose-response characteristic for different baseline substrate conditions and for dentifrices containing fluoride in the range 1,450-12,500 ppm (as NaF) in a lowly and highly cariogenic pH-cycling model could be revealed.…”

Biomimetic Action of Zinc Hydroxyapatite on Remineralization of Enamel and Dentin: A Review

“…These studies would seem to validate the purpose of this review, namely, to determine whether products containing zinc–carbonate hydroxyapatite can be considered a viable alternative to fluorine or other prophylactic systems in terms of remineralization. It is known based on the literature that fluoride is a remineralizing agent [ 27 , 28 , 29 ]. CCP-ACP also appears to be another valuable system [ 30 , 31 , 32 , 70 ] for reducing dental sensitivity [ 71 ].…”

Demineralisationshemmende Effekte hochfluorid- und kalziumhaltiger zahnärztlicher Lacke in Kombination mit regulär- oder hochfluoridierter Zahnpasta auf Schmelz - in vitro

“…Aus Rinderschneidezähnen wurden 300 Schmelzblöcke (5 mm x 3,5 mm x 3 mm) hergestellt. Die Schmelzblöcke wurden in Epoxidharz eingebettet, plan geschliffen und poliert [24]. Die Hälfte der Oberfläche jedes Probekörpers wurde mit Nagellack bedeckt (Gesundkontrollfläche (GF)), um eine mögliche Beschädigung (z.…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (ΔΔZ) as well as lesion depth (ΔLD) and fluoride concentration (0-1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride's ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27,28], in situ [14,29,30], and in vitro [4,5,7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

“…While comparing numerous different experiments with similar settings [3], different methods of initial demineralization [4], or different lowly and highly cariogenic pH-cycling conditions [5], these fluoride doseresponses were observed. However, only a few studies presented data on the correlations between mineral loss and fluoride concentrations [5][6][7] and only in one of the abovementioned pH-cycling models (human or bovine) dentin has been analyzed [5]. In this study, a significant dose-response characteristic for different baseline substrate conditions and for dentifrices containing fluoride in the range 1,450-12,500 ppm (as NaF) in a lowly and highly cariogenic pH-cycling model could be revealed.…”

Biomimetic Action of Zinc Hydroxyapatite on Remineralization of Enamel and Dentin: A Review

“…These studies would seem to validate the purpose of this review, namely, to determine whether products containing zinc–carbonate hydroxyapatite can be considered a viable alternative to fluorine or other prophylactic systems in terms of remineralization. It is known based on the literature that fluoride is a remineralizing agent [ 27 , 28 , 29 ]. CCP-ACP also appears to be another valuable system [ 30 , 31 , 32 , 70 ] for reducing dental sensitivity [ 71 ].…”

Demineralisationshemmende Effekte hochfluorid- und kalziumhaltiger zahnärztlicher Lacke in Kombination mit regulär- oder hochfluoridierter Zahnpasta auf Schmelz - in vitro

“…Aus Rinderschneidezähnen wurden 300 Schmelzblöcke (5 mm x 3,5 mm x 3 mm) hergestellt. Die Schmelzblöcke wurden in Epoxidharz eingebettet, plan geschliffen und poliert [24]. Die Hälfte der Oberfläche jedes Probekörpers wurde mit Nagellack bedeckt (Gesundkontrollfläche (GF)), um eine mögliche Beschädigung (z.…”