Influence of high cholesterol feeding on the pattern and progression of experimental cerebral ischemia

Chui, De Hua; Marotta, Jessica; Zang, Jiankun; Liu, Y.; Rao, ML; Liu, D. S.

doi:10.1016/0753-3322(91)90005-e

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…High blood cholesterol concentrations modify the action of platelets such that exposure to low density lipoprotein cholesterol enhances platelet aggregation by its action on platelet activating factor 16. Rabbits fed a high cholesterol diet have larger experimentally induced infarcts associated with an increase in platelet deposition in the thrombus at the infarct 17. Exposure to high levels of cholesterol also reduces the responsiveness of large blood vessels, though not small vessels, to vasodilatory stimuli 18.…”

Section: Discussionmentioning

confidence: 99%

Influence of cholesterol on survival after stroke: retrospective study

Dyker

Weir

Lees

1997

BMJ

102

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Objective: To study the comparative importance of environment and genes in the development of islet cell autoimmunity associated with insulin dependent diabetes mellitus. Design: Population based study of diabetic twins. Setting: Danish population. Subjects: 18 monozygotic and 36 dizygotic twin pairs with one or both partners having insulin dependent diabetes. Main outcome measures: Presence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase (GAD65) in serum samples from twin pairs 10 years (range 0-30 years) and 9.5 years (2-30 years) after onset of disease. Results: In those with diabetes the prevalence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase in the 26 monozygotic twins was 38%, 85%, and 92%, respectively, and in the dizygotic twins was 57%, 70%, and 57%, respectively. In those without diabetes the proportions were 20%, 50%, and 40% in the 10 monozygotic twins and 26%, 49%, and 40% in the 35 dizygotic twins. Conclusion: There is no difference between the prevalence of islet cell autoantibodies in dizygotic and monozygotic twins without diabetes, suggesting that islet cell autoimmunity is environmentally rather than genetically determined. Furthermore, the prevalence of islet cell antibodies was higher in the non-diabetic twins than in other first degree relatives of patients with insulin dependent diabetes. This implies that the prenatal or early postnatal period during which twins are exposed to the same environment, in contrast with that experienced by first degree relatives, is of aetiological importance.

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Section: Discussionmentioning

confidence: 99%

Influence of cholesterol on survival after stroke: retrospective study

Dyker

Weir

Lees

1997

BMJ

102

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“…Identifying other factors predisposing to HT may lead to new preventive strategies. The risk of spontaneous intracerebral hemorrhage (ICH) increases with lower total cholesterol levels in humans [8] and animals [9], but not in patients treated with intensive lipid-lowering therapy after ischemic stroke [10]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Lipid Profiles on the Risk of Hemorrhagic Transformation after Ischemic Stroke: Systematic Review

Nardi

Leys²,

Cordonnier³

et al. 2011

Cerebrovasc Dis Extra

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Background: It has been suggested that low cholesterol levels might be associated with an increased risk of hemorrhagic transformation (HT) in patients with acute cerebral ischemia. We systematically reviewed the literature to determine the influence of lipid profiles on the HT risk. Methods: We searched PubMed from 1966 and EMBASE from 1980 for studies that investigated the association between lipid profiles and HT. We performed a meta-analysis (weighted mean difference method) for the comparison between presence and absence of HT (all or symptomatic) for total, low-density-lipoprotein (LDL) and high-density-lipoprotein (HDL) cholesterol, and triglycerides. Results: Eight studies investigating 1,763 patients were eligible, but none was designed specifically to address this question. All studies recruited acute stroke patients selected on the presumed cause of cerebral ischemia or treatment received. The meta-analysis showed that: (i) patients with all HT had lower LDL cholesterol levels (p = 0.008) but no difference in HDL cholesterol levels (p = 0.066), total cholesterol (p = 0.129) and triglycerides (p = 0.900); (ii) patients with symptomatic HT had lower total cholesterol levels (p = 0.035) but did not differ in LDL (p = 0.056) and HDL cholesterol (p = 0.138) and triglyceride (p = 0.851) levels. Conclusion: HT is associated with baseline total and LDL cholesterol levels, but the mechanism of this association needs to be explored to identify preventive strategies.

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“…Upon high-cholesterol diet, rabbits exhibited 34.7 times elevated LDL concentrations (Table 1) [28]. After 5 weeks, atheromas were noted in the internal carotid and basilar arteries [28].…”

Section: Insights From Hypercholesterolemia Models: Utility As Modmentioning

confidence: 99%

“…Upon high-cholesterol diet, rabbits exhibited 34.7 times elevated LDL concentrations (Table 1) [28]. After 5 weeks, atheromas were noted in the internal carotid and basilar arteries [28]. When exposed to focal cerebral ischemia induced by sephadex-G75 polymer injections, a high-cholesterol diet increased the mean infarct size probably as a consequence of platelet-rich thrombus accumulation, but reduced brain hemorrhage formation [28].…”

Section: Insights From Hypercholesterolemia Models: Utility As Modmentioning

confidence: 99%

Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies

Hermann

Doeppner²,

Popa‐Wagner

2019

Neural Plasticity

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Major efforts are currently made promoting neuronal plasticity and brain remodeling in the postacute stroke phase. Experimental studies evaluating new stroke therapies are mostly performed in rodents, which compared to humans exhibit a short lifespan. These studies widely employ young, otherwise healthy, rodents that lack the vascular risk factors and comorbidities of stroke patients. These risk factors compromise postischemic neurological recovery and brain plasticity and in several contexts reduce the brain responsiveness to recovery-inducing plasticity-promoting treatments. By examining risk factor models, which have hitherto been used for studying experimentally induced ischemic stroke, this review outlines the possibilities and limitations of risk factor models in the evaluation of plasticity-promoting and restorative stroke treatments.

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Influence of high cholesterol feeding on the pattern and progression of experimental cerebral ischemia

Cited by 6 publications

References 10 publications

Influence of cholesterol on survival after stroke: retrospective study

Influence of cholesterol on survival after stroke: retrospective study

Influence of Lipid Profiles on the Risk of Hemorrhagic Transformation after Ischemic Stroke: Systematic Review

Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies

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