Influence of gestational diabetes on circadian rhythms of children and their association with fetal adiposity

Zornoza-Moreno, Matilde; Fuentes-Hernández, Silvia; Prieto-Sánchez, María T; Blanco, José E.; Pagán, Ana; Rol, María Ángeles; Parrilla, Juan José; Madrid, Juan Antonio; Sánchez-Solís, Manuel Rolandi; Larqué, Elvira

doi:10.1002/dmrr.2417

Cited by 15 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we previously reported impairment in some parameters that define temperature maturation and the CFI at 6 months in the GDM+insulin group. 27 Baddock et al 28 reported differences in mean rectal and skin temperatures in infants bed-sharing with their parents with respect to when they were sleeping on their own in a cot. In order to exclude this potential confounding factor, all the babies slept in a cot in the parents' room and none of them shared the bed.…”

Section: Discussionmentioning

confidence: 99%

Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?

et al. 2014

View full text Add to dashboard Cite

show abstract

“…While it is known that disrupted circadian rhythms can be detrimental to reproductive success (Dolatshad et al, 2005;Mahoney, 2010), it remains largely unknown how they change from the non-pregnant state to pregnancy. Understanding the role of circadian rhythms in regulating both behavior and tissue-specific circadian function during the estrous cycle and in pregnancy is an essential first step toward elucidating the underlying mechanisms associated with infertility and pregnancy complications, which are more prevalent in women with disrupted circadian rhythms (Goldberg et al, 2012;Nisa et al, 2018;Pappa et al, 2013;Zornoza-Moreno et al, 2013). We hypothesize that circadian timekeeping during late pregnancy influences mouse behavior and reproductive tissue circadian function in preparation for labor.…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy

Yaw

Duong

Nguyen

et al. 2020

J of Neuroscience Research

View full text Add to dashboard Cite

Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in fertility, it remains unexplored how circadian rhythms change within reproductive tissues during pregnancy. To determine how estrous cycle and pregnancy impact phase relationships of reproductive tissues, we used PER2::Luciferase (PER2::LUC) circadian reporter mice and determined the time of day of PER2::LUC peak (phase) in the SCN, pituitary, uterus, and ovary. The relationships between reproductive tissue PER2::LUC phases changed throughout the estrous cycle and late pregnancy and were accompanied by changes to PER2::LUC period in the SCN, uterus, and ovary. To determine if the phase relationship adaptations were driven by sex steroids, we asked if progesterone, a hormone involved in estrous cyclicity and pregnancy, could regulate Per2‐luciferase expression. Using an in vitro transfection assay, we found that progesterone increased Per2‐luciferase expression in immortalized SCN (SCN2.2) and arcuate nucleus (KTAR) cells. In addition, progesterone shortened PER2::LUC period in ex vivo uterine tissue recordings collected during pregnancy. As progesterone dramatically increases during pregnancy, we evaluated wheel‐running patterns in PER2::LUC mice. We confirmed that activity levels decrease during pregnancy and found that activity onset was delayed. Although SCN, but not arcuate nucleus, PER2::LUC period changed during late pregnancy, onset of locomotor activity did not correlate with SCN or arcuate nucleus PER2::LUC period.

show abstract

“…In further work Zornoza-Moreno et al (2013) examined development of infant rhythm from the neonatal period through 6 months of age. Few investigators jointly study maternal and infant rhythm.…”

Section: Introductionmentioning

confidence: 99%

Maternal and infant activity: Analytic approaches for the study of circadian rhythm

Thomas

Burr

Spieker

2015

Infant Behavior and Development

View full text Add to dashboard Cite

The study of infant and mother circadian rhythm entails choice of instruments appropriate for use in the home environment as well as selection of analytic approach that characterizes circadian rhythm. While actigraphy monitoring suits the needs of home study, limited studies have examined mother and infant rhythm derived from actigraphy. Among this existing research a variety of analyses have been employed to characterize 24-h rhythm, reducing ability to evaluate and synthesize findings. Few studies have examined the correspondence of mother and infant circadian parameters for the most frequently cited approaches: cosinor, non-parametric circadian rhythm analysis (NPCRA), and autocorrelation function (ACF). The purpose of this research was to examine analytic approaches in the study of mother and infant circadian activity rhythm. Forty-three healthy mother and infant pairs were studied in the home environment over a 72 h period at infant age 4, 8, and 12 weeks. Activity was recorded continuously using actigraphy monitors and mothers completed a diary. Parameters of circadian rhythm were generated from cosinor analysis, NPCRA, and ACF. The correlation among measures of rhythm center (cosinor mesor, NPCRA mid level), strength or fit of 24-h period (cosinor magnitude and R2, NPCRA amplitude and relative amplitude (RA)), phase (cosinor acrophase, NPCRA M10 and L5 midpoint), and rhythm stability and variability (NPCRA interdaily stability (IS) and intradaily variability (IV), ACF) was assessed, and additionally the effect size (eta2) for change over time evaluated. Results suggest that cosinor analysis, NPCRA, and autocorrelation provide several comparable parameters of infant and maternal circadian rhythm center, fit, and phase. IS and IV were strongly correlated with the 24-h cycle fit. The circadian parameters analyzed offer separate insight into rhythm and differing effect size for the detection of change over time. Findings inform selection of analysis and circadian parameters in the study of maternal and infant activity rhythm.

show abstract

Influence of gestational diabetes on circadian rhythms of children and their association with fetal adiposity

Abstract: Fetal adiposity correlated with a worse circadian rhythm regulation in ODM. In addition, ODM insulin-treated showed a disturbed pattern of the circadian function index of temperature activity at 6 months of age.

Cited by 15 publications

References 32 publications

Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?

Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?

Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy

Maternal and infant activity: Analytic approaches for the study of circadian rhythm

Contact Info

Product

Resources

About