Influence of gamma and electron beam sterilization on the stability of a premixed injectable calcium phosphate cement for trauma indications

Murray, Kieran A.; Collins, Maurice N.; O'Sullivan, Regina P.; Ren, Guang; Devine, Declan M.; Murphy, Alan; Sadło, Jarosław; O'Sullivan, Carol; McEvoy, Brian P.; Vrain, Olivier; O’Neill, Cathriona; Insley, Gerard

doi:10.1016/j.jmbbm.2017.09.002

Cited by 8 publications

(9 citation statements)

References 37 publications

(9 reference statements)

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“…PLGA and CPC particles are known to be hygroscopic in nature, and it is this addition of water molecules present on the surface of these particles that allows for the formation of hydroxyl free radicals to occur through water radiolysis . Further, it has been reported that exposure of the inorganic phases of CPC pastes to irradiation can lead to the formation of hydroxyl free radicals . The subsequent addition of hydroxyl free radicals results into abstraction of hydrogen atoms from the glycosidic bonds, thereby rendering them weaker, less rigid and easier to cleave .…”

Section: Discussionmentioning

confidence: 99%

“…Similar to the injectability, the cohesion and washout resistance of the cements began to deteriorate for all irradiated CPCs, especially for CPC/CMC groups. This reduction is attributed to the reduced viscosifying effect of CMC caused by radiation degradation, which makes it more difficult for CMC to bind the CPC particles together . Consequently, the cements are more susceptible to particulate fragmentation and leakage.…”

Section: Discussionmentioning

confidence: 99%

“…[58][59][60]65 Further, it has been reported that exposure of the inorganic phases of CPC pastes to irradiation can lead to the formation of hydroxyl free radicals. 69,70 The subsequent addition of hydroxyl free radicals results into abstraction of hydrogen atoms from the glycosidic bonds, thereby rendering them weaker, less rigid and easier to cleave. 30,60 The addition of free radical-induced oxidative degradation accelerates a further reduction in the average chain length of CMC and the formation of smaller, more mobile anionic polymer chains that reduce the viscoelastic and gelation properties of CMC.…”

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

“…This reduction is attributed to the reduced viscosifying effect of CMC caused by radiation degradation, which makes it more difficult for CMC to bind the CPC particles together. 30,31,59,69 Consequently, the cements are more susceptible to particulate fragmentation and leakage.…”

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

“…The irradiation of CPC particles has also been shown to inhibit the degree of phase transformation for apatiteforming CPCs, 19,56 and can induce the formation of undesired free radicals on the particles surface. 69 Chen et al investigated the effect of gamma irradiation on calcium phosphate-sulfate composite cements and determined that non-irradiated cements had a~10% higher apatite conversion ratio compared to irradiated cements in the range of 25-100 kGy. 56 This can also explain why the phase transformation appears to be diminished for CPCs irradiated at a higher dose in our study.…”

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

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Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

Kucko

Martinez

et al. 2019

J Biomed Mater Res B

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Injectable, self‐setting calcium phosphate cements (CPCs) are synthetic bone substitutes considered favorable for the repair and regeneration of bone due to their osteocompatibility and unique handling properties. However, their clinical applicability can be compromised due to insufficient cohesion upon injection into the body coupled with poor degradation rates that restricts new bone formation. Consequently, carboxymethyl cellulose (CMC) was incorporated into CPC formulations to improve their cohesion and injectability while poly (D,L‐lactic‐co‐glycolic acid) (PLGA) porogens were added to introduce macroporosity and improve their biodegradation rate. Like most biomaterials, CPCs are gamma irradiated before clinical use to ensure sufficient sterilization. However, it is well known that gamma irradiation also reduces the molecular weight of CMC and PLGA via chain scission, which affects their material properties. Therefore, the aim of this study is to measure the effect that gamma irradiation has on the molecular weight of CMC at varying doses of 15, 40, or 80 kGy and investigate how this affects the handling (i.e., injectability, cohesion, washout, and setting times) and in vitro degradation behavior of CPC formulations. Results reveal that the molecular weight of CMC decreases with increasing gamma irradiation dose, thereby reducing the viscosifying capabilities of CMC, which causes CPCs to deteriorate more readily. Further, the addition of CMC seems to inhibit the degree of phase transformation during cement setting while the subsequent reduction in molecular weight of PLGA after gamma irradiation improves the in vitro degradation rate of CPCs due to the faster degradation rate of low molecular weight PLGA. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2216–2228, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

Section: Cmc Molecular Weight Analysismentioning

confidence: 99%

See 3 more Smart Citations

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

Kucko

Martinez

et al. 2019

J Biomed Mater Res B

View full text Add to dashboard Buy / Rent full text

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Influence of gamma and electron beam sterilization on the stability of a premixed injectable calcium phosphate cement for trauma indications

Cited by 8 publications

References 37 publications

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

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Influence of gamma and electron beam sterilization on the stability of a premixed injectable calcium phosphate cement for trauma indications

Cited by 8 publications

References 37 publications

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

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Product

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Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose

Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly (_D,L -lactic-co-glycolic acid) porogens and carboxymethyl cellulose