Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay

Amakura, Yoshiaki; Tsutsumi, Tomoaki; Sasaki, Kumiko; Nakamura, Masafumi; Yoshida, Takashi; Maitani, Tamio

doi:10.1016/j.phytochem.2007.07.022

Cited by 85 publications

(58 citation statements)

References 53 publications

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“…influence of this glycosidic feature on the activity of the related anthraquinones was similar to our previous findings that the AhR activity of isoflavones tended to be weakened by glycosidation [4]. It is notable that the presence of a hydroxyl group at C-8 on the anthraquinone skeleton is necessary for AhR activation.…”

Section: Identification and Ahr Activity Of Constituentssupporting

confidence: 90%

“…This tendency has been observed even for flavonoid ligands [4]. In the present study, nepitrin (15) and homoplantagenin (16), which are flavone glucosides, were found to have noticeable AhR activity.…”

Section: Identification and Ahr Activity Of Constituentssupporting

confidence: 58%

“…Functional elucidation of AhR activation by non-toxic ligands such as food constituents has been reported in recent years [4][5][6]. The AhR has been identified as a target of several signaling pathways that cross-talk with its own regulatory pathway, such as proteasomal degradation, redox-sensitive transcription factors, and mitogen-activated protein kinases (MAPKs) [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary

et al. 2014

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Many recent studies have suggested that activation of the aryl hydrocarbon receptor (AhR) reduces immune responses, thus suppressing allergies and autoimmune diseases. In our continuing study on natural AhR agonists in foods, we examined the influence of 37 health food materials on the AhR using a reporter gene assay, and found that aqueous ethanol extracts of cassia seed and rosemary had particularly high AhR activity. To characterize the AhR-activating substances in these samples, the chemical constituents of the respective extracts were identified. From an active ethyl acetate fraction of the cassia seed extract, eight aromatic compounds were isolated. Among these compounds, aurantio-obtusin, an anthraquinone, elicited marked AhR activation. Chromatographic separation of an active ethyl acetate fraction of the rosemary extract gave nine compounds. Among these compounds, cirsimaritin induced AhR activity at 10-10 2 μM, and nepitrin and homoplantagenin, which are flavone glucosides, showed marked AhR activation at 10-10 3 μM.

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Section: Identification and Ahr Activity Of Constituentssupporting

confidence: 90%

Section: Identification and Ahr Activity Of Constituentssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

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Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary

et al. 2014

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“…A more recent study confi rmed these data; for example, apigenin (weak agonist) showed notable inhibitory effects on the in vitro activation of AhR induced by 2,3,7,8 -tetrachlorodibenzo -p -dioxin ( TCDD ). Moreover, it has been suggested that glycosides, in general, show lower or no AhR responses than the corresponding aglycones [68] .…”

Section: Aryl Hydrocarbon Receptormentioning

confidence: 99%

Flavonoids

Hodek

2012

Metabolism of Drugs and Other Xenobiotics

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“…In particular, compounds possessing a polyphenolic structure can bind to xenosensors and hormone receptors. Examples of natural activators of AhR are indole-3-carbinole (autolysis product of 3-indolmethyl glucosinolate) from cruciferous vegetables (e.g., cabbage), resveratrol from grapes, some phytoestrogens from soy and citrus fruits, and some flavonoids like chrysin and baicalein [18,19]. Resveratrol is a stilbene phytoalexin (a compound produced in response to fungal or bacterial attack) produced by grape species, peanuts and lingonberries [20,21].…”

Section: Nature's Own Xenobioticsmentioning

confidence: 99%

Receptors mediating toxicity and their involvement in endocrine disruption

Rüegg

Penttinen-Damdimopoulou

Mäkelä

et al. 2009

Experientia Supplementum

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Abstract. Many toxic compounds exert their harmful effects by activating of certain receptors, which in turn leads to dysregulation of transcription. Some of these receptors are so called xenosensors. They are activated by external chemicals and evoke a cascade of events that lead to the elimination of the chemical from the system. Other receptors that are modulated by toxic substances are hormone receptors, particularly the ones of the nuclear receptor family. Some environmental chemicals resemble endogenous hormones and can falsely activate these receptors, leading to undesired activity in the cell. Furthermore, excessive activation of the xenosensors can lead to disturbances of the integrity of the system as well. In this chapter, the concepts of receptor-mediated toxicity and hormone disruption are introduced. We start by describing environmental chemicals that can bind to xenosensors and nuclear hormone receptors. We then describe the receptors most commonly targeted by environmental chemicals. Finally, the mechanisms by which receptor-mediated events can disrupt the system are depicted.

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Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay

Cited by 85 publications

References 53 publications

Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary

Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary

Flavonoids

Receptors mediating toxicity and their involvement in endocrine disruption

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