Influence of fatty acid anilides present in toxic oils on the metabolism of exogenous arachidonic acid in cultured human endothelial cells

The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.

“…Work with N-phenyllinoleamide has shown that this anilide potentiates the release of endogenous arachidonic acid from cell membrane phospholipids and enhances the metabolic pathways of the latter, increasing the biosyntheses of its vasoactive endogenous metabolites (59). However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.

“…Work with N-phenyllinoleamide has shown that this anilide potentiates the release of endogenous arachidonic acid from cell membrane phospholipids and enhances the metabolic pathways of the latter, increasing the biosyntheses of its vasoactive endogenous metabolites (59). However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish Toxic Oil Syndrome 20 Years after Its Onset: A Multidisciplinary Review of Scientific Knowledge

“…However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.

“…Work with N-phenyllinoleamide has shown that this anilide potentiates the release of endogenous arachidonic acid from cell membrane phospholipids and enhances the metabolic pathways of the latter, increasing the biosyntheses of its vasoactive endogenous metabolites (59). However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish Toxic Oil Syndrome 20 Years after Its Onset: A Multidisciplinary Review of Scientific Knowledge

“…However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.

“…Work with N-phenyllinoleamide has shown that this anilide potentiates the release of endogenous arachidonic acid from cell membrane phospholipids and enhances the metabolic pathways of the latter, increasing the biosyntheses of its vasoactive endogenous metabolites (59). However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”

The Spanish Toxic Oil Syndrome 20 Years after Its Onset: A Multidisciplinary Review of Scientific Knowledge

“…However, Pich et al (60), using fatty acid anilides, described a significantly reduced release of arachidonic acid from cell membranes and impairment of stimulated prostacyclin synthesis accompanied by an antifibrinolytic activity. This apparently contrasting observation was explained by a dual stimulatory and inhibitory effect on the conversion of exogenous arachidonic acid as a function of preincubation time with Nphenyllinoleamide alone, because the oleic acid anilide did not show any inhibitory effect with incubation time.…”