Abstract:Since several years dynorphin, a member of the opioid peptide family, was suggested to play a regulatory role in numerous functional pathways of the brain. In line with its localization in hippocampus, amygdala, hypothalamus and striatum these functions resemble learning and memory, emotional control and stress response. Male prodynorphin-deficient (Dyn KO) mice display an anxiolytic phenotype [see abstract A5]. However, emotional control and stress response depend on hormonal state and differ between sexes. I… Show more
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