Influence of enzyme immobilization and skin-sensor interface on non-invasive glucose determination from interstitial fluid obtained by magnetohydrodynamic extraction

Kemp, Emily; Palomäki, Tommi; Ruuth, Ida A.; Boeva, Zhanna A.; Nurminen, Teemu A.; Vänskä, Risto T.; Zschaechner, Laura K.; Pérez, Alejandro García; Hakala, Tuuli A.; Wardale, Melissa; Hæggström, Edward; Bobacka, Johan

doi:10.1016/j.bios.2022.114123

Cited by 26 publications

(23 citation statements)

References 44 publications

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“…In future work, the ISF glucose will be determined by an electrochemical biosensor, which will allow miniaturization of the device. We have demonstrated the integration of MHD and electrochemical sensors for glucose monitoring in a previous work 41 . As evident from that work, the use of electrochemical sensors overcomes the need for sample collection because the samples can be measured at the extraction site.…”

Section: Discussionmentioning

confidence: 99%

Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring

Hakala¹,

Zschaechner

Vänskä

et al. 2022

Sci Rep

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The benefits of continuous glucose monitoring (CGM) in diabetes management are extensively documented. Yet, the broader adoption of CGM systems is limited by their cost and invasiveness. Current CGM devices, requiring implantation or the use of hypodermic needles, fail to offer a convenient solution. We have demonstrated that magnetohydrodynamics (MHD) is effective at extracting dermal interstitial fluid (ISF) containing glucose, without the use of needles. Here we present the first study of ISF sampling with MHD for glucose monitoring in humans. We conducted 10 glucose tolerance tests on 5 healthy volunteers and obtained a significant correlation between the concentration of glucose in ISF samples extracted with MHD and capillary blood glucose samples. Upon calibration and time lag removal, the data indicate a Mean Absolute Relative Difference (MARD) of 12.9% and Precision Absolute Relative Difference of 13.1%. In view of these results, we discuss the potential value and limitations of MHD in needle-free glucose monitoring.

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Section: Discussionmentioning

confidence: 99%

Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring

Hakala¹,

Zschaechner

Vänskä

et al. 2022

Sci Rep

Self Cite

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show abstract

“…A potential alternative physical mechanism for enhancing noninvasive ISF collection has been demonstrated through the application of magnetohydrodynamics (MHD) (Figure 7G). 176 induce 13-times higher flux of ISF compared to RI, thus, minimizing the sample dilution factor. A limited clinical trial showed close correlation between the ISF glucose concentrations extracted with MHD and blood glucose levels.…”

Section: Isf-patch-based Glucose Sensorsmentioning

confidence: 99%

“…As a result, dilution effects appear to be a problem for every RI platform. A potential alternative physical mechanism for enhancing noninvasive ISF collection has been demonstrated through the application of magnetohydrodynamics (MHD) (Figure G) . Such MHD ISF extraction was integrated with a PB-based GOx amperometric biosensor.…”

Section: Strategies For Accessing Biofluids For Glucose Monitoringmentioning

confidence: 99%

“…This approach has been demonstrated to induce 13-times higher flux of ISF compared to RI, thus, minimizing the sample dilution factor. A limited clinical trial showed close correlation between the ISF glucose concentrations extracted with MHD and blood glucose levels. , Some other potential solutions to decrease the dilution factor of ISF samples have been demonstrated by introducing a painless pretreatment of the skin with microneedles (MNs) . The MN-based treatment of skin areas from healthy and diabetic rats has been shown to increase the ISF glucose extraction by approximately 1.6 times.…”

Section: Strategies For Accessing Biofluids For Glucose Monitoringmentioning

confidence: 99%

Section: Strategies For Accessing Biofluids For Glucose Monitoringmentioning

confidence: 99%

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Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review

et al. 2023

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With the rising diabetic population, the demand for glucose sensing devices has also been on an increasing trend. Accordingly, the field of glucose biosensors for diabetes management has witnessed tremendous scientific and technological advancements since the introduction of the first enzymatic glucose biosensor in the 1960s. Among these, electrochemical biosensors hold considerable potential for tracking dynamic glucose profiles in real time. The recent evolution of wearable devices has opened opportunities to use alternative body fluids in a pain-free, noninvasive or minimally invasive manner. This review aims to present a comprehensive report about the status and promise of wearable electrochemical sensors for on-body glucose monitoring. We start by highlighting the importance of diabetes management and how sensors can contribute toward its effective monitoring. We then discuss the electrochemical glucose sensing mechanisms, evolution of such glucose sensors over time, different versions of wearable glucose biosensors targeting various biofluids, and multiplexed wearable sensors toward optimal diabetes management. Finally, we focus on the commercial aspects of wearable glucose biosensors, starting with existing continuous glucose monitors, followed by other emerging sensing technologies, and concluding with highlighting the key prospects toward personalized diabetes management in connection to an autonomous closed-loop artificial pancreas.

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Electrospinning Nanofibers as Stretchable Sensors for Wearable Devices

Zhu,

Zheng,

2023

Macromolecular Bioscience

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Wearable devices attract great attention in intelligent medicine, electronic skin, artificial intelligence robots, and so on. However, boundedness of traditional sensors based on rigid materials unconstrained self‐multilayer structure assembly and dense substrate in stretchability and permeability limits their applications. The network structure of the elastomeric nanofibers gives them excellent air permeability and stretchability. By introducing metal nanofillers, intrinsic conductive polymers, carbon materials, and other methods to construct conductive paths, stretchable conductors can be effectively prepared by elastomeric nanofibers, showing great potential in the field of flexible sensors. This perspective briefly introduces the representative preparations of conductive thermoplastic polyurethane, nylon, and hydrogel nanofibers by electrospinning and the application of integrated electronic devices in biological signal detection. The main challenge is to unify the stretchability and conductivity of the fiber structure.

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Influence of enzyme immobilization and skin-sensor interface on non-invasive glucose determination from interstitial fluid obtained by magnetohydrodynamic extraction

Cited by 26 publications

References 44 publications

Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring

Pilot study in human healthy volunteers on the use of magnetohydrodynamics in needle-free continuous glucose monitoring

Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review

Electrospinning Nanofibers as Stretchable Sensors for Wearable Devices

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