Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor

Begliuomini, Silvia; Casarosa, Elena; Pluchino, Nicola; Lenzi, E; Centofanti, M.; Freschi, Letizia; Pieri, Matteo; Genazzani, Alessandro D.; Luisi, Stefano; Genazzani, Andrea R.

doi:10.1093/humrep/del479

Cited by 212 publications

(165 citation statements)

References 43 publications

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“…This study showed that the BDNF was positively correlated with E 2 , a finding consistent with previous studies [15,18]. Increasing evidence showed the synthesis of BDNF was positively correlated with the synthesis of estrogen.…”

Section: Discussionsupporting

confidence: 92%

“…In the study, there was no relationship between BDNF and P in FF. However, Begliuomini et al [18] demonstrated that the level of BDNF was positively correlated with P in fertile women. Chen et al [20] found BNDF significantly inhibited the production of P in a dose-dependent manner when they cultured human granulose-lutein cells in medium without or with different dosage of BDNF.…”

Section: Discussionmentioning

confidence: 99%

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Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Wang¹,

Sun²,

Zhen³

et al. 2011

J Assist Reprod Genet

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Purpose The aim of the study was to evaluate the correlation between BDNF and oocyte maturation and to verify whether BDNF could predict in vitro fertilization (IVF) outcome. Methods The follicle fluid (FF) for BDNF, E 2 and P assay were obtained from 59 patients undergoing intracytoplasmic sperm injection (ICSI). The women were divided into two groups by pregnancy outcome and their clinical and lab data were compared. And the correlation of BDNF with E 2 , P, age, and IVF data were analyzed. Results Positive correlation was observed between BDNF and E 2 concentration in FF. BDNF was positively correlated with the rate of mature oocytes collected and cleavage rate. Conclusions The BDNF in FF could not predict IVF outcome, but BDNF in FF might play an important role in the maturation of oocyte and development of oocyte into preimplantation embryo.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Wang¹,

Sun²,

Zhen³

et al. 2011

J Assist Reprod Genet

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“…Various studies in mice (Advani et al., 2009; Ren‐Patterson et al., 2006) and in humans (Shalev et al., 2009; Verhagen et al., 2010) have shown a sex difference in the effect of BDNF. This difference may be related to the interactions between BDNF and sex hormones such as estradiol (Begliuomini et al., 2007; Sohrabji et al., 1995) and testosterone (Hill et al., 2012; Verhovshek et al., 2010). Another explanation for the sex difference in the interaction effect might lie in the lower variability found for maternal warmth compared to paternal warmth.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, the val66met polymorphism of the BDNF gene affects the onset of multiple sclerosis (MS) only in men and increases the risk of MS only in women (Mirowska‐Guzel, Mach, Gromadzka, Czlonkowski, & Czlonkowska, 2008). These differences may be explained by interactions between BDNF and sex hormones such as estradiol (Begliuomini et al., 2007; Sohrabji, Miranda, & Toran‐Allerand, 1995) and testosterone (Hill, Wu, Kwek, & van den Buuse, 2012; Verhovshek, Cai, Osborne, & Sengelaub, 2010). In rats, estrogen has been shown to regulate BDNF mRNA levels, possibly via an estrogen response element on the BDNF gene (Sohrabji et al., 1995).…”

Section: Introductionmentioning

confidence: 99%

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Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

Avinun

Knafo‐Noam

2017

Brain and Behavior

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BackgroundParental warmth has been associated with various child behaviors, from effortful control to callous‐unemotional traits. Factors that have been shown to affect parental warmth include heritability and child behavior. However, there is limited knowledge about which specific genes are involved, how they interact with child behavior, how they affect differential parenting, and how they affect fathers. We examined what affects paternal and maternal warmth by focusing on the child's prosocial behavior and parents’ genotype, specifically a Valine to Methionine substitution at codon 66 in the brain‐derived neurotrophic factor (BDNF) gene.MethodsData was available from a sample of 6.5 year‐old twins, consisting of 369 mothers and 663 children and 255 fathers and 458 children. Self‐reports were used to assess mothers’ and fathers’ warmth. Child prosociality was assessed with the other‐parent report and experimental assessments.ResultsMothers’ warmth was not affected by their BDNF genotype, neither as a main effect nor in an interaction with child prosociality. Fathers with the Met allele scored higher on warmth. Additionally, there was a significant interaction between fathers’ BDNF genotype and child prosociality. For fathers with the Met allele there was a positive association between warmth and child prosociality. Conversely, for fathers with the Val/Val genotype there was no association between warmth and child prosociality. Results were repeated longitudinally in a subsample with data on age 8–9 years. A direct within family analysis showed that fathers with the Met allele were more likely than Val/Val carriers to exhibit differential parenting toward twins who differed in their prosocial behavior. The same pattern of findings was found with mother‐rated and experimentally assessed prosociality.ConclusionsThese results shed light on the genetic and environmental underpinnings of paternal behavior and differential parenting.

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Plasma Brain‐Derived Neurotrophic Factor (BDNF) and serum cortisol levels in a sample of workers exposed to occupational stress and suffering from Adjustment Disorders

et al. 2019

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Introduction Decreased plasma BDNF (pBDNF) levels have been proposed as a biomarker in illness phases of mood disorders. Serum cortisol (seC) levels are an index of energy mobilization and stress. The aim of this cross‐sectional study was to evaluate pBDNF and seC levels in workers exposed to occupational stress and suffering from Adjustment Disorders (AD) compared to healthy workers. Methods Plasma BDNF and seC levels were measured by means of specific immunoassays in 64 AD patients and 38 healthy controls. Perceived and occupational stress was evaluated in patients and controls using the Psychological Stress Measure (PSM) and the Job Content Questionnaire (JCQ). Psychopatological symptoms in patients were assessed using specific rating scales. Results Plasma BDNF levels resulted significantly higher in patients than in controls, whereas no significant differences were found for seC levels. In patients but not in controls pBDNF levels showed a significant positive correlation with seC levels. Perceived stress levels were positively correlated with all psychopatological rating scales scores. Conclusions BDNF could play a key role in the pathophysiology of stress‐related disorders and its peripheral levels elevation could contribute to protect neurons under stress. Further research is needed focusing on biomarkers for stress‐related disorders as a potential tool for the diagnosis and prevention of occupational diseases.

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Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor

Abstract: Plasma BDNF levels are influenced by hormonal status. Modifications in BDNF circulating levels during the menstrual cycle suggest a potential role for gonadal sex hormones (E(2) and progesterone) in regulating neurotrophin expression.

Cited by 212 publications

References 43 publications

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients

Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

Plasma Brain‐Derived Neurotrophic Factor (BDNF) and serum cortisol levels in a sample of workers exposed to occupational stress and suffering from Adjustment Disorders

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