2017
DOI: 10.1021/acs.chemrestox.7b00224
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Abstract: Faithful replication of DNA is a critical aspect in maintaining genome integrity. DNA polymerases are responsible for replicating DNA, and high-fidelity polymerases do this rapidly and at low error rates. Upon exposure to exogenous or endogenous substances, DNA can become damaged and this can alter the speed and fidelity of a DNA polymerase. In this instance, DNA polymerases are confronted with an obstacle that can result in genomic instability during replication, for example, by nucleotide misinsertion or rep… Show more

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Cited by 10 publications
(9 citation statements)
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“…Single-molecule Förster Resonance Energy Transfer (smFRET), an experimental technique used to study the dynamics of a wide variety of biomolecules, from polymerases to ribosomes, to G-protein coupled receptors, could benefit greatly from quantitative MD simulation comparison [47][48][49][50][51]. Investigations involving MD interpretations of smFRET experiments have been a major focus for some time [52].…”
Section: Plos Computational Biologymentioning
confidence: 99%
“…Single-molecule Förster Resonance Energy Transfer (smFRET), an experimental technique used to study the dynamics of a wide variety of biomolecules, from polymerases to ribosomes, to G-protein coupled receptors, could benefit greatly from quantitative MD simulation comparison [47][48][49][50][51]. Investigations involving MD interpretations of smFRET experiments have been a major focus for some time [52].…”
Section: Plos Computational Biologymentioning
confidence: 99%
“…Further studies that monitor DNA polymerase dynamics with mutated residues that stabilize and destabilize Exo mode are needed to determine their influence on proofreading and, ultimately, their role in mutagenesis and carcinogenesis in humans. 6 …”
Section: Discussionmentioning
confidence: 99%
“…Our understanding of how translesion synthesis (TLS) DNA polymerases access the target DNA selectively and how the action of replicative polymerase is coordinated with translesion DNA polymerase is limited. Single-molecule in vitro studies of these TLS polymerases have been reviewed recently . Single particle tracking of E. coli Pol IV in live cells revealed static Pol IV molecules at replication sites upon DNA damage.…”
Section: Dna Motor Proteinsmentioning
confidence: 99%
“…Single-molecule in vitro studies of these TLS polymerases have been reviewed recently. 308 Single particle tracking of E. coli Pol IV in live cells revealed static Pol IV molecules at replication sites upon DNA damage. The mechanism of recruitment of Pol IV to DNA damage sites was shown to be dependent on the type of DNA damage.…”
Section: Dna Polymerasesmentioning
confidence: 99%