Influence of dietary mannan oligosaccharide and clinoptilolite on hematological, biochemical and gut histological parameters in weaned pigs

Valpotić, Hrvoje; Barić-Rafaj, Renata; Mrljak, Vladimir; Grabarević, Željko; Samardžija, Marko; Šperanda, Marcela; Žaja, Ivona Žura; Đuričić, Dražen; Bach, Ana; Harapin, I.; Folnožić, Ivan; Vince, Silvijo; Valpotić, Ivica

doi:10.18054/pb.v119i1.4407

Cited by 11 publications

(12 citation statements)

References 24 publications

(38 reference statements)

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“…Similarly, supplementation dietary MOS did not affect the WBC count, HCT, neutrophil count, mononuclear leukocyte count, or eosinophil count of dairy cows or their offspring ( Franklin et al, 2005 ). Other studies on the effects of MOS in monogastric animals have reported similar results: supplementation dietary MOS did not impact RBC count, hemoglobin, HCT, or MCHC of weanling pigs in one study ( Valpotić et al, 2017 ; Dos Anjos et al, 2019 ), or RBC count, WBC count, lymphocyte count, or diarrhea score in another study ( Zhao, Jung & Kim, 2012 ), and did not influence monocyte, basophil, or eosinophil counts in Arbor Acres broiler chickens ( Attia et al, 2017 ).…”

Section: Discussionsupporting

confidence: 54%

Effects of mannan oligosaccharides on growth performance, nutrient digestibility, ruminal fermentation and hematological parameters in sheep

Zheng

Zhou

Zeng

et al. 2021

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Background Mannan oligosaccharides (MOS) are a promising feed additive in animal husbandry due to mainly improving animal health status. The purpose of this study was to investigate the effects of MOS on growth performance, nutrient digestibility, ruminal fermentation, and twelve hematological parameters in sheep. Methods Ninety-six healthy Hu rams with similar body weights were chosen and divided into four treatment groups (twenty-four rams in each group), in which four different doses of MOS were tested: 0%, 0.8%, 1.6% and 2.4% of the basal diet (on an as-fed basis). Results The results showed that supplementation dietary MOS did not affect feed intake, body weight, average daily weight gain, or ruminal short-chain fatty acids (SCFAs) concentration; the ratio of individual fatty acids to total SCFAs, the C2/C3 ratio, and the hematological parameters in the sheep were also unaltered (P > 0.05). Conversely, supplementation dietary MOS increased the dry matter, organic matter, crude protein, neutral detergent fiber, acid detergent fiber, and ash apparent digestibility (P < 0.05), and decreased the ruminal ammonia concentration in the sheep (P < 0.05), especially at a dose of 1.6%. Conclusions This indicates that supplementation dietary MOS improved nutrient utilization by the sheep and nitrogen metabolism in the rumen; however, the effects are too slight to interfere with the basal metabolism in the sheep.

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Section: Discussionsupporting

confidence: 54%

Effects of mannan oligosaccharides on growth performance, nutrient digestibility, ruminal fermentation and hematological parameters in sheep

Zheng

Zhou

Zeng

et al. 2021

PeerJ

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“…In the functional study using the CPL-fed mice as the immune cell donors immunostumulatory effect of the agent was also observed (37). Regarding limited reports on potential adverse effects of CPL as a feed supplement, tested in pigs (19) it has been shown that the agent was not associated with any harmful side effects on monitored blood and gut histological parameters as well on impairment of general health status of pigs.…”

Section: Frey Et Al (42)mentioning

confidence: 92%

“…Therefore, zeolites have been recognized as interesting nanoporous materials and became subjects of research in different areas of chemistry, and are now widely used in industrial, agricultural, environmental and biological technologies (13,33), but have also attracted interest for use in molecular medicine (26). Several toxicological studies as well as hematological, biochemical and histopathological analyses of a natural CPL proved that this compound is non-toxic and safe for use in human and veterinary medicine (19,25,31,(34)(35)(36). The CPL utilization in veterinary medicine showed that it is capable to act as detoxificating (including mycotoxins and heavy metals), antioxidant, hemostatic, anti-diarrheic, growth-promoting and immunostimulating agent (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

“…In the past two decades, a significant amount of research has been focused on immunomodulators (IMs) and nutraceuticals (NCs), substances which are capable of stimulating functions of the immune system and the bioactive components of feed that have shown positive impact on gut health and performance, and were harmless for the animal and the environment (4,8,11,12). Promising results have been obtained with natural, synthetic or modified clay minerals, zeolites (13) among which clinoptilolite (CPL) is the best known as zootechnical and biomedical feed ingredient widely reported in the scientific literature and used in farm animal nutrition as candidate to replace AGP in farm animals (14, 15) due to its unique antibacterial properties, safety and efficacy as dietary supplement, particularly reported for swine (16)(17)(18)(19). So far, CPL has been successfully used in animal biotechnology and veterinary medicine as the agent which is capable to ameliorate mycotoxicosis, maintain gut health by acting favorably on intestinal microbiota, reduce, prevent and treat diarrheal disease in farm animals, decrease the level of toxic heavy metals and ammonia, improve immunity, general health and growth performance in animals of veterinary and biomedical importance, and thus exhibiting potentials of both an IM and NC (4,[20][21][22][23][24].…”

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confidence: 99%

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Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

et al. 2017

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I n the past two decades many substances of natural or synthetic origin were studied as potential alternatives to antibiotic growth promoters (AGP) and some of them, particularly immunomodulators (IMs) and nutraceuticals (NCs), have shown to be capable of stimulating functions of the immune system and improving general health. At the same time, they were shown to be harmless for animals and the environment. Promising results have been obtained with natural clay minerals, zeolites among which clinoptilolite (CPL) is the best known as zootechnical and biomedical feed ingredient widely reported in scientific literature and used in farm animal nutrition. CPL has a potential to replace AGP due to its unique anti-bacterial properties, safety and efficacy as dietary supplement in food animals unifying potentials of an IM and NC. Currently, there INTRODUCTIONT he phrase "survival of the fittest" as an alternative to "natural selection" has been adopted and published in 1868 by Charles Darwin (1), and nowadays is becoming so true because of the rapid emergence of antibiotic resistant strains of pathogenic microbes of biomedical, particularly veterinary importance. This is a consequence of non-clinical use and misuse of dietary antibiotics for more than sixty years to prevent bacterial infections and to enhance performance in livestock production, mostly in chickens and pigs (2). Namely, the increased sanitary problems in intensive farming of food animals have been overcome thus far by adding sub-therapeutic doses of antibiotic growth promoters (AGP) infeed to enhance production efficiency by increasing growth rate, improv- ing feed utilization and reducing mortality from clinical disease is well documented particularly in swine production systems (3). However, the consumers especially in developed countries are becoming increasingly concerned about drug residues in meat and other animal products (4). In addition, it has been suggested that the continuous use of antibiotics may contribute to a reservoir of drugresistant bacteria (5) which may be capable of transferring their resistance to pathogenic bacteria in both animals and humans (6). As a result, many countries have banned or are banning the inclusion of antibiotics in diets as a routine means of growth promotion. The first experience of an AGP ban in Sweden in 1986 indicated a reduction in growth and an increase in morbidity and mortality rates in weaned pigs, which emphasized the importance of antibiotic use in intensive swine production(7). The total ban of dietary AGP in the EU countries since January 1, 2006 (EU Regulation No. 1831 and the elimination of their use in animal feed and water in the USA effective January 1, 2017 (FDA, CVM 2012, VFD Basics 2017) has had a serious influence on both health and performance of food animals underlining the need to develop alternative dietary and non-dietary strategies to evaluate the potential antimicrobial agents for their replacement (8). According to the World Health Organization, most antibiotics will not ...

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“…Therefore it is a very interesting compound on the medical market and has recently been approved in the EU as a feed additive for use as a mycotoxin binder in veterinary medicine, particularly in the livestock, swine and poultry industry (VALPOTIĆ et al, 2017a;VALPOTIĆ et al, 2017b;VALPOTIĆ et al, 2018). In addition, recently, ĐURIČIĆ et al (2017) evaluated the effects of dietary clinoptilolite (CPL), a novel vibroactivated and micronized modification (Vibrosorb) of the natural mineral, in lactating dairy cows, on milk composition, SCC and the incidence of subclinical mastitis from the third to the seventh month of gestation.…”

Section: Prevention and Therapy Of Mastitismentioning

confidence: 99%

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

et al. 2018

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M. SAMARDŽIJA: Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control -a review. Vet. arhiv 88, 535-557, 2018. ABSTRACT Mastitis in dairy cows is the inflammation of the mammary gland, and is the most important cause of economic losses in the modern dairy industry. Bovine mastitis is often infectious and can be caused by some 150 microbial species. The environment of the dairy cow is heavily colonized by microbiota, while milk is an ideal medium for propagation of the bacteria and causative agents. Staphylococcus aureus is the most common pathogen isolated from the mammary gland capable of causing health disorders in humans. Milk from an infected mammary gland has a different chemical composition compared to milk from healthy cows. Certain differences, such as protein components specific to inflamed tissue, are currently being considered in 2018 M. Benić et al.: Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control the development of diagnostic tools for mastitis. The known risk factors for mastitis can result in mastitis at the quarter, cow and herd levels. Mastitis treatment includes both preventive and therapy measures, and is primarily based on the use of antibiotics. Recent approaches to mastitis therapy have been focused on the design and use of natural therapeutics, such as zeolites, ozone and propolis, that could serve as alternatives to antibiotics.

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Influence of dietary mannan oligosaccharide and clinoptilolite on hematological, biochemical and gut histological parameters in weaned pigs

Cited by 11 publications

References 24 publications

Effects of mannan oligosaccharides on growth performance, nutrient digestibility, ruminal fermentation and hematological parameters in sheep

Effects of mannan oligosaccharides on growth performance, nutrient digestibility, ruminal fermentation and hematological parameters in sheep

Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

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