Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure

Gustafsson, Ida; Brendorp, Bente; Seibæk, Marie; Burchardt, Hans; Hildebrandt, Per; Køber, Lars; Torp‐Pedersen, Christian

doi:10.1016/j.jacc.2003.11.024

Cited by 234 publications

(157 citation statements)

References 35 publications

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“…we did not adjust for the number of tests performed), we found a sex difference in the prognostic importance of high HbA 1c levels on the risk of all-cause mortality; it was greater in women than in men, in agreement with the findings from a Framingham sub-study, and previous large cohort studies of heart failure patients and myocardial infarction patients, where diabetes was found to carry a worse prognosis in women than in men [29][30][31]. What may underlie these findings is not clear, but they may relate to a higher prevalence of high HbA 1c values as was found in women from the SCOUT trial.…”

Section: Discussionsupporting

confidence: 89%

Relationship between HbA1c levels and risk of cardiovascular adverse outcomes and all-cause mortality in overweight and obese cardiovascular high-risk women and men with type 2 diabetes

et al. 2012

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Aims/hypothesis The optimal HbA 1c concentration for prevention of macrovascular complications and deaths in obese cardiovascular high-risk patients with type 2 diabetes remains to be established and was therefore studied in this post hoc analysis of the Sibutramine Cardiovascular OUTcomes (SCOUT) trial, which enrolled overweight and obese patients with type 2 diabetes and/or cardiovascular disease. Methods HRs for meeting the primary endpoint (nonfatal myocardial infarction, nonfatal stroke, resuscitated cardiac arrest or cardiovascular death) and all-cause mortality were analysed using Cox regression models. Results Of 8,252 patients with type 2 diabetes included in SCOUT, 7,479 had measurements of HbA 1c available at baseline (i.e. study randomisation). Median age was 62 years (range 51-86 years), median BMI was 34.0 kg/m 2 (24.8-65.1 kg/m 2 ) and 44% were women. The median HbA 1c concentration was 7.2% (3.8-15.9%) (55 mmol/l [18-150 mmol/l]) and median diabetes duration was 7 years (0-57 years). For each 1 percentage point HbA 1c increase, the adjusted HR for the primary endpoint was 1.17 (95% CI 1.11, 1.23); no differential sex effect was observed (p00.12 for interaction). In contrast, the risk of all-cause mortality was found to be greater in women than in men: HR 1.22 (1.10, 1.34) vs 1.12 (1.04, 1.20) for each 1 percentage point HbA 1c increase (p 00.02 for interaction). There was no evidence of increased risk associated with HbA 1c ≤6.4% (≤46 mmol/l). Glucose-lowering treatment regimens, diabetes duration or a history of cardiovascular disease did not modify the associations. Diabetologia (2012) 55:2348-2355 DOI 10.1007/s00125-012-2584 Conclusions/interpretation In overweight, cardiovascular high-risk patients with type 2 diabetes, increasing HbA 1c concentrations were associated with increasing risks of cardiovascular adverse outcomes and all-cause mortality.

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Section: Discussionsupporting

confidence: 89%

Relationship between HbA1c levels and risk of cardiovascular adverse outcomes and all-cause mortality in overweight and obese cardiovascular high-risk women and men with type 2 diabetes

et al. 2012

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“…Diagnosis of diabetes was based on a self-report by the patient or by documentation in the patient's medical records 22 . Possible explanations of higher prevalence of diabetes in North American subjects are differences in the etiology of HF in those populations.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of DM in patients with HF has been associated with an increased risk of poor outcomes 11,22,[31][32][33][34] . An analysis from the Studies of Left Ventricular Dysfunction trials and registry program demonstrated that the presence of DM in patients with HF resulted in an increased risk for mortality 31 .…”

Section: Discussionmentioning

confidence: 99%

Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Begum¹,

Abdullah

Khan³

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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Background: There are an increasing number of hospital admissions due to heart failure with diabetes or prediabetes in different hospitals in Bangladesh. But very little is known about the frequency of diabetes and prediabetes and the effect of its presence on the characteristics and outcome in patients hospitalized for heart failure. The objective of this study was to find out the frequency of diabetes and prediabetes in heart failure patients and to assess their association with in-hospital outcome. Methods: This cross sectional analytical study was done in the department of Biochemistry and Cardiology of Bangabandhu Sheikh Mujib Medical University in collaboration with department of Cardiology of National Institute of Cardiovascular Diseases, and Dhaka Medical College Hospital from July 2010 to June 2011. After proper ethical consideration a total two hundred and fifty heart failure patients were enrolled in the study by nonrandom sampling. Fasting blood sugar was done in all patients and oral glucose tolerance test was done in patients with impaired fasting glycaemia. Results: The frequency of prediabetes among the total population was 12.8% (95% CI,) and that of diabetes was 37.2% (95% CI, 31.2-43.2%). Improvement was achieved in 27 (84.4%) cases in prediabetic group, 75 (80.6%) cases in diabetic group and 105 (84.0%) cases in nondiabetic group. Mortality rates in prediabetes, diabetes and nondiabetes were 5 (15.6%); 18 (19.4%) and 20 (16.0%) respectively. The differences found among the three groups were not statistically significant (p>0.05). Length of hospital stay was also similar in all groups of study subjects. Conclusion: Frequency of diabetes among heart failure patients is high and pre-diabetes is not negligible in our country. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only.

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“…W badaniach BEST i Studies Of Left Ventricular Dysfunction (SOLVD) opisywano cukrzycę jako niezależny czynnik prognostyczny zgonu (u większości pacjentów występowała HF o podłożu niedokrwiennym) [390,392]. Również w badaniach Danish Investigations and Arrhythmia ON Dofetilide (DIAMOND) i Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) wykazano, że cukrzyca jest niezależnym czynnikiem predykcyjnym zgonu, niezależnie od przyczyny [393,394].…”

Section: Cukrzyca I Niewydolność Sercaunclassified

Wytyczne ESC dotyczące cukrzycy, stanu przedcukrzycowego i chorób układu sercowo- -naczyniowego opracowane we współpracy z EASD

Rydén

Grant

Anker³

et al. 2013

Kardiol Pol

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Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure

Abstract: Diabetes is a potent, independent risk factor for mortality in patients hospitalized with HF. The excess risk in diabetic patients appears to be particularly prominent in females.

Cited by 234 publications

References 35 publications

Relationship between HbA1c levels and risk of cardiovascular adverse outcomes and all-cause mortality in overweight and obese cardiovascular high-risk women and men with type 2 diabetes

Relationship between HbA1c levels and risk of cardiovascular adverse outcomes and all-cause mortality in overweight and obese cardiovascular high-risk women and men with type 2 diabetes

Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Wytyczne ESC dotyczące cukrzycy, stanu przedcukrzycowego i chorób układu sercowo- -naczyniowego opracowane we współpracy z EASD

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