Influence of Dental Prostheses on Cognitive Functioning in Elderly Population: A Systematic Review

Ahmed, Syed Ershad; Mohan, Jayashree; Kalaignan, Parithimar; Kandasamy, Saravanan; Raju, Ramesh; Champakesan, Bharath

doi:10.4103/jpbs.jpbs_773_20

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…However, most of those studies had a cross-sectional design of oral rehabilitation with partial or removable denture and cognitive impairment decline. 15 31 32 A clear mechanism through longitudinal studies is yet to be revealed.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

Park

Lee

et al. 2022

Yonsei Med J

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Purpose The aim of this study was to investigate the association between the changes in masticatory function and cognitive impairment by analyzing longitudinal data of older Korean patients. Materials and Methods Patients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020 (follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified into two groups, the dementia group (n=122) and the control group (n=366). Changes in masticatory function were calculated using the total functional tooth unit (T-FTU) in both groups. The incidence of tooth extraction (%) and the subsequent rehabilitation during the observation period were also evaluated. Results In the dementia group, T-FTU significantly decreased from T1 to T2 (9.81±2.78 to 9.11±3.16, respectively, p =0.008), while no significant change was observed in the control group. During the mean observation period of 9 years, significantly more teeth were extracted and neglected to be prosthetically restored in the dementia group than in the control group. Regression analysis revealed that the number of missing teeth neglected [odds ratio (OR)=1.195, 95% confidence interval (CI)=1.025–1.393, p =0.023] and previous alcohol consumption (OR=4.445, 95% CI=1.831–1.795, p =0.001) were the most significant risk factors of dementia. Conclusion There might be a causative relationship between the neglected missing dentition and the onset of dementia.

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Section: Discussionmentioning

confidence: 99%

The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

Park

Lee

et al. 2022

Yonsei Med J

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“…The success of psychoeducational interventions depends on clear communication of theoretical contents and the active involvement of carers in practice sequences to implement new skills [ 303 , 385 ]. Support of oral hygiene and health, prevention and diagnosis of periodontal disease are promising approaches in dementia care that have not yet been addressed in multidomain interventions but should receive more attention in the future [ 363 , 367 , 371 , 409 ]. In this context, diabetes mellitus, recently identified as an additional risk factor for the development of AD [ 410 ], should also be mentioned, even though the underlying mechanisms have not yet been clarified [ 411 ].…”

Section: Discussionmentioning

confidence: 99%

“…Improvement of mastication by the provision of prosthesis and the therapy of oral complaints led to an increase in the social activity of patients [ 370 ]. The provision of dentures was also shown to be beneficial in terms of cognitive function [ 371 ].…”

Section: Individual Approachesmentioning

confidence: 99%

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Ablinger¹,

Dressel

Rott³

et al. 2022

Biomedicines

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Alzheimer’s disease is one of the most common neurodegenerative diseases in the western population. The incidence of this disease increases with age. Rising life expectancy and the resulting increase in the ratio of elderly in the population are likely to exacerbate socioeconomic problems. Alzheimer’s disease is a multifactorial disease. In addition to amyloidogenic processing leading to plaques, and tau pathology, but also other molecular causes such as oxidative stress or inflammation play a crucial role. We summarize the molecular mechanisms leading to Alzheimer’s disease and which potential interventions are known to interfere with these mechanisms, focusing on nutritional approaches and physical activity but also the beneficial effects of cognition-oriented treatments with a focus on language and communication. Interestingly, recent findings also suggest a causal link between oral conditions, such as periodontitis or edentulism, and Alzheimer’s disease, raising the question of whether dental intervention in Alzheimer’s patients can be beneficial as well. Unfortunately, all previous single-domain interventions have been shown to have limited benefit to patients. However, the latest studies indicate that combining these efforts into multidomain approaches may have increased preventive or therapeutic potential. Therefore, as another emphasis in this review, we provide an overview of current literature dealing with studies combining the above-mentioned approaches and discuss potential advantages compared to monotherapies. Considering current literature and intervention options, we also propose a multidomain interdisciplinary approach for the treatment of Alzheimer’s disease patients that synergistically links the individual approaches. In conclusion, this review highlights the need to combine different approaches in an interdisciplinary manner, to address the future challenges of Alzheimer’s disease.

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“…Oral and cognitive health are interconnected [ 100 ] and the recovery of masticatory activity can prevent cognitive decline [ 101 , 102 , 103 ]. The use of dental human prostheses successfully reduces cognitive consequences of masticatory dysfunction [ 104 ]. In animal studies, the relation between decrease in masticatory activity, due to a soft diet [ 28 , 30 , 105 ] or tooth loss [ 106 ], and memory impairment have been previously demonstrated [ 107 ].…”

Section: Running Experiencing Novelty and Mastication To Learn Faster...mentioning

confidence: 99%

The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus

Mendes

Almeida

Falsoni

et al. 2022

IJMS

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As aging and cognitive decline progresses, the impact of a sedentary lifestyle on the appearance of environment-dependent cellular morphologies in the brain becomes more apparent. Sedentary living is also associated with poor oral health, which is known to correlate with the rate of cognitive decline. Here, we will review the evidence for the interplay between mastication and environmental enrichment and assess the impact of each on the structure of the brain. In previous studies, we explored the relationship between behavior and the morphological features of dentate gyrus glial fibrillary acidic protein (GFAP)-positive astrocytes during aging in contrasting environments and in the context of induced masticatory dysfunction. Hierarchical cluster and discriminant analysis of GFAP-positive astrocytes from the dentate gyrus molecular layer revealed that the proportion of AST1 (astrocyte arbors with greater complexity phenotype) and AST2 (lower complexity) are differentially affected by environment, aging and masticatory dysfunction, but the relationship is not straightforward. Here we re-evaluated our previous reconstructions by comparing dorsal and ventral astrocyte morphologies in the dentate gyrus, and we found that morphological complexity was the variable that contributed most to cluster formation across the experimental groups. In general, reducing masticatory activity increases astrocyte morphological complexity, and the effect is most marked in the ventral dentate gyrus, whereas the effect of environment was more marked in the dorsal dentate gyrus. All morphotypes retained their basic structural organization in intact tissue, suggesting that they are subtypes with a non-proliferative astrocyte profile. In summary, the increased complexity of astrocytes in situations where neuronal loss and behavioral deficits are present is counterintuitive, but highlights the need to better understand the role of the astrocyte in these conditions.

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Influence of Dental Prostheses on Cognitive Functioning in Elderly Population: A Systematic Review

Cited by 9 publications

References 19 publications

The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus

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