Influence of Cimetidine Coadministration on the Pharmacokinetics of Sotalol Enantiomers in an Anaesthetized Rat Model: Evidence Supporting Active Renal Excretion of Sotalol

Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics

“…Enantiomer-enantiomer interactions, which were discussed above at the level of plasma protein binding, may also be possible directly at the level of drug elimination. Evidence is available showing that the renal clearance of S-sotalol, which is actively secreted renally [91] and not appreciably bound to plasma proteins, is enhanced by the presence of its optical antipode when administered as the racemate to rats [92].…”

RP-HPLC Method for the Simultaneous Determination of Captopril and H2-Receptor Antagonist: Application to Interaction Studies

“…It is reported that Hypertension and gastrointestinal disorders are two common co-existing conditions, therefore H 2receptor antagonists and antiarrhythmic agents like calcium channel blockers, ACE Inhibitors may be administered to patients to cure hypertension with GIT problems. Co administration of H 2 receptor antagonists and cardiovascular drugs are described in number of cases [19,20]. On this basis, it became apparent to develop and validate for the first time a simultaneous method for the estimation of these drugs in bulk material, dosage formulations and in human serum which can be used for therapeutic monitoring in clinical practice.…”