Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders

Abstract

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No Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders: A Retrospective Study

“…Due to the pernicious effects of CM on the course of both disorders and treatment responses [ 7 , 21 , 22 ], our findings support the importance of evaluating CM in both female and male patients with MDD and BD in clinical practice, in order to identify patients who may require more careful monitoring and special therapeutic attention.…”

“…Although prevalence estimates can vary among studies [ 19 ], the extremely high CM rate in MDD and BD is noted to be a consistent finding, reaching up to 50% of individuals in both diagnostic groups who reported at least one CM type [ 7 , 19 , 20 ]. Exposure to CM has a negative impact on the course of the disorders, as it is associated with an increased risk in MDD or BD first-onset, earlier onset, more severe illness, and poor treatment response [ 7 , 21 , 22 ].…”

Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders

“…This may be particularly true for metabolic syndrome components. Second, childhood maltreatment increases the risk of comorbid substance use disorders in BD (tobacco, alcohol, cannabis and illicit drugs) (Agnew-Blais & Danese, 2016; Etain et al, 2013; Grillault Laroche et al, 2022 b ), that are well-known providers of poor physical health (WHO, 2018). Third, childhood maltreatment may act on several biological pathways that may predispose to a higher medical morbidity.…”

Specific effects of five subtypes of childhood maltreatment on suicide behaviours in Chinese adolescents: the moderating effect of sex and residence

“…Future research could take multi-informant measures to obtain these sensitive information, such as prospective caregiver reports (usually from the mother) (Newbury et al, 2018). Third, other important information of childhood maltreatment was not evaluated, such as the age of the first maltreatment experience, duration, intensity, frequency and perpetrator of abuse or neglect (Grillault et al, 2022). In the next step, we will conduct a survey to collect more related information to further explore the impact of timing, duration, severity and offender of childhood maltreatment (Duarte et al, 2020).…”

“…Since both subtypes of childhood maltreatment and stages of suicide behaviours are not exclusive, disentanglement of the characteristics and pattern of the associations is warranted (Grillault et al, 2022). Although many related previous studies have been conducted in community and clinical samples (Berardelli et al, 2022;Grillault et al, 2022;Hassan et al, 2016;Walsh et al, 2021;Xie et al, 2018), several key research questions remain controversial and inconclusive. First, are the effects of different subtypes of childhood maltreatment on suicide behaviours equivalent or heterogeneous?…”