Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation

Eickmeier, Ira; Seidel, Daniel; Grün, Joachim R.; Derkow, Katja; Lehnardt, Seija; Kühl, Anja A.; Schott, Eckart

doi:10.1016/j.jhep.2014.02.011

Cited by 22 publications

(20 citation statements)

References 31 publications

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“…The down-regulated VEGF-A, was responsive to recruits macrophages (Walczak et al, 2004 ; Tanaka and Iwakiri, 2016 ), indicating the finishing of the acute immune response. Whereas, the up-regulated CCR9, a marker of gut-homing lymphocyte, suggested the entering of intestinal activated lymphocytes (Eickmeier et al, 2014 ). This may relate to hepatic inflammation, since the gut-primed T cells, preferentially migrating to the liver, could induce autoimmune disease (Eickmeier et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Wang

Cui

et al. 2018

Front. Physiol.

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In aquafeeds, fish-meal has been commonly replaced with plant protein, which often causes enteritis. Currently, foodborne enteritis has few solutions in regards to prevention or cures. The recovery mechanism from enteritis in herbivorous fish may further help understand prevention or therapy. However, few reports could be found regarding the recovery or resilience to fish foodborne enteritis. In this study, grass carp was used as an animal model for soybean meal induced enteritis and it was found that the fish could adapt to the soybean meal at a moderate level of substitution. Resilience to soybean meal stress was found in the 40% soybean meal group for juvenile fish at growth performance, morphological and gene expression levels, after a 7-week feeding trial. Furthermore, the intestinal transcriptomic data, including transcriptome and miRNAome, was applied to demonstrate resilience mechanisms. The result of this study revealed that in juvenile grass carp after a 7-week feeding cycle with 40% soybean meal, the intestine recovered via enhancing both an immune tolerance and wound healing, the liver gradually adapted via re-balancing immune responses, such as phagosome and complement cascades. Also, many immune factors in the gut and liver were systemically revealed among stages of on-setting, remising, and recovering (or relief). In addition, miRNA regulation played a key role in switching immune states. Thus, the present data systemically demonstrated that the molecular adaptation mechanism of fish gut-liver immunity is involved in the resilience to soybean meal stress.

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Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Wang

Cui

et al. 2018

Front. Physiol.

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“…12 A recent study showed that gut-primed CD8 + T cells had a strong propensity to migrate to the liver, but liver-primed CD8 + T cells were incapable of migrating to gut. 13 Bliss et al observed that the gut-derived CD4 + T cells migrated to liver and induce hepatic inflammation in IL-10 knockout mice infected with Trichinella spiralis. 10 Considering the intimate relationship between gut and liver, in this study, we focus on the migration behavior of gut-derived lymphocytes to liver in NAFLD mice model.…”

Section: Discussionmentioning

confidence: 99%

Gut‐derived lymphocyte recruitment to liver and induce liver injury in non‐alcoholic fatty liver disease mouse model

Ying

Zhang

et al. 2016

J of Gastro and Hepatol

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“…57 Additionally, in a murine model, CD8 + T cells activated in GALT caused immune-mediated cholangitis in an antigen-dependent manner, and gut-primed CD8 + T cells activated in GALT could migrate to the liver, whereas liver-activated CD8 + T cells did not home to the intestine. 58,59 Conversely, one in vitro study showed that murine sinusoidal endothelium could induce gut trophism on CD4 + T cells. 60 In general, there are no differences in the amount of total circulating CD4 + and CD8 + T cells in the peripheral blood of patients with PSC-UC and UC compared to healthy controls.…”

Section: Recruitment Of Lymphocytes To the Livermentioning

confidence: 99%

Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis

Krijger

Wildenberg

Jonge

et al. 2019

Journal of Hepatology

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Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree, characterised by stricturing bile duct disease and progression to liver fibrosis. The pathophysiology of PSC is still unknown. The concurrence with inflammatory bowel disease (IBD) in about 70% of cases has led to the hypothesis that gut-homing lymphocytes aberrantly traffic to the liver, contributing to disease pathogenesis in patients with both PSC and IBD (PSC-IBD). The discovery of mutual trafficking pathways of lymphocytes to target tissues, and expression of gut-specific adhesion molecules and chemokines in the liver has pointed in this direction. There is now increasing interest in using drugs that intervene with these trafficking pathways (e.g. vedolizumab, etrolizumab) for the treatment of PSC-IBD. In this review we discuss what is currently known about the immunological interactions between the gut and the liver in concomitant PSC and IBD, as well as potential therapeutic options for intervening in these mechanisms.

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Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation

Cited by 22 publications

References 31 publications

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Gut‐derived lymphocyte recruitment to liver and induce liver injury in non‐alcoholic fatty liver disease mouse model

Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis

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