Influence of catheter type on occurrence of thrombophlebitis during peripheral intravenous nutrition

Madan, Manu; Alexander, D.J.; McMahon, Michael

doi:10.1016/0140-6736(92)91007-u

Cited by 71 publications

(24 citation statements)

References 17 publications

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“…With amino acid concentration at 1g/kg/d in a 700kcal/L solution, the osmolarity of the 33% fat solution was over 1,000mOsm/kg. The osmotic pressure of solutions for peripheral infusion should not exceed 800 to 1,000mOsm/L (3,22,23), and the 33% fat solution used in this study would therefore not be available for PPN without using especially long catheters (24,25). PPN is a useful technique, and our results suggest that 1,400kcal/2,000mL can be provided by using fat emulsion.…”

Section: Discussionmentioning

confidence: 93%

Comparison of Glucose and Fat as Energy Sources in Peripheral Parenteral Nutrition in Rats.

Fukuta

Arii

Matsuda

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryGlucose is usually chosen as the energy source for total parenteral nutrition. However, the optimal glucose: fat ratio for peripheral parenteral nutrition has not been examined sufficiently. We compared glucose: fat ratios in hypocaloric nutrition. Male SD rats were given hypocaloric parenteral nutrition (approx. 190kcal/kg/d) for 5 d after laparotomy. The hypocaloric solutions used contained 0, 33, 50, 67 or 100% of the non-protein energy in the form of fat. Body weight change, nitrogen balance, organ weights, and hepatic, splenic and plasma biochemistries were assessed. Body weight increase in the 67 and 100% fat groups was significantly greater than that in the 0% fat group. Ni trogen balance was the same in all groups. Hepatic glycogen content was significantly lower in the 100% fat group than that in the 0% fat group. The weight of epididymal fat deposits was significantly lower in the 0% fat group than in the 50 and 67% fat groups. On the other hand, tissue triglyceride content and plasma lipid levels in the 100% fat group were significantly higher than in the 0% fat group, and were also higher than in the control group. It is suggested that combinations of glucose and fat have sparing effects on body fat and hepatic glyco gen. Combinations of glucose and fat as non-protein energy sources were superior to glucose or fat alone for hypocaloric parenteral nutrition. Key Words rat, peripheral parenteral nutrition, laparotomy, glucose, fat emulsion Peripheral parenteral nutrition (PPN) has been developed for reasons of safety, simplicity and cost. The use of PPN avoids certain disadvantages seen in total paren teral nutrition, such as complexity of technique and catheter-related sepsis (1, 2). However, PPN also has disadvantages such as thrombophlebitis, which is a serious problem (3) and limits the amount of energy that can be supplied. The causes of thrombophlebitis are thought to be the pH (4), osmolarity (5) and titratable acidity (6) of the solution. To avoid increases in the osmotic pressure of the solution and provide energy sources effectively via the peripheral vein, fat emulsions are frequently 47

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Section: Discussionmentioning

confidence: 93%

Comparison of Glucose and Fat as Energy Sources in Peripheral Parenteral Nutrition in Rats.

Fukuta

Arii

Matsuda

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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show abstract

“…In keeping with this, peripheral intravenous nutrition caused phlebitis in all patients using Teflon cannulas, but in only 7% using silicone catheters. The risk of phlebitis was very low even when nutrition solutions of an osmolarity of 1250 mOsm/kg were administered via the latter catheters (Madan M et al, 1992). In our study, the same peripheral catheters were used in both groups and therefore the role of catheter type in the development of phlebitis cannot be established here.…”

Section: Discussionmentioning

confidence: 65%

“…In keeping with this, peripheral intravenous nutrition caused phlebitis in all patients using Teflon cannulas, but in only 7% using silicone catheters. The risk of phlebitis was very low even when nutrition solutions of an osmolarity of 1250 mOsm/kg were administered via the latter catheters (Madan et al, 1992). Glucose solutions are acid and hyperosmolar, the 15% solution pH ranging between 3.5-5.5 and osmolarity 832.5 mOsm/kg and the 20% solution 4.0 and 1110 mOsm/kg.…”

Section: Introductionmentioning

confidence: 99%

“…A poor fluid tolerance during the first days of life can be anticipated and cautious fluid administration might be indicated especially in such infants. Earlier studies suggest that the development of phlebitis does not depend so much on the osmolarity of the solution as other factors causing phlebitis, for example material of the catheter (Madan et al, 1992). Factors affecting the development of infusion phlebitis include vein characteristics, size and material of the catheter, duration of infusion and the osmolarity and pH of the infusion solution.…”

Section: Introductionmentioning

confidence: 99%

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Glucose Infusions into Peripheral Veins in Neonates with Hypoglycemia

Tammela¹,

Vanhatalo²

2011

Hypoglycemia - Causes and Occurrences

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“…Many studies have demonstrated that adequate nutritional support can be provided for at least 2 weeks by peripheral parenteral nutrition (Maddan et al 1992;Payne-James & Khawaja, 1993). This avoids potentially serious complications associated with the insertion and use of central feeding catheters.…”

Section: Parenteral Nutritionmentioning

confidence: 99%

Disease and malnutrition in British hospitals

1997

Proc. Nutr. Soc.

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Influence of catheter type on occurrence of thrombophlebitis during peripheral intravenous nutrition

Cited by 71 publications

References 17 publications

Comparison of Glucose and Fat as Energy Sources in Peripheral Parenteral Nutrition in Rats.

Comparison of Glucose and Fat as Energy Sources in Peripheral Parenteral Nutrition in Rats.

Glucose Infusions into Peripheral Veins in Neonates with Hypoglycemia

Disease and malnutrition in British hospitals

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