Influence of calcium ions on the stability, microstructure and in vitro digestion fate of zein-propylene glycol alginate-tea saponin ternary complex particles for the delivery of resveratrol

Evaluating the structural properties of bioactive‐loaded nanocarriers with modern analytical tools

“…Fluorescence spectra of bioactive‐loaded nanovehicles including (a) resveratrol in various levels of γ‐CD, (b) cyclodextrin metal–organic framework, and (c) cyclodextrin metal–organic framework/chitosan (0, 0.2, 0.4, 0.6, 0.8, and 1.0 mg/mL) (Reprinted with permission from Qiu et al., 2020); (d) zein, curcumin–piperine–zein–carrageenan nanoparticles (CPZC), and nanoparticles cross‐linked by cationic calcium ions (CPZCCa 2+ ) (Reprinted with permission from Chen et al., 2020); (e and f) resveratrol and coenzyme Q10 co‐encapsulated zein– propylene glycol alginate nanoparticles at different rhamnolipid concentrations (Reprinted with permission from Wei, Yu, et al., 2020)…”

“…Wei, Yang et al. (2020) designed food‐grade nanocomplexes for the co‐delivery of resveratrol–coenzyme Q10 and employed FS to notice the polarity of surrounding environment for intrinsic fluorophore of proteins. According to Figure 7e, the produced propylene glycol alginate–zein nanocomplexes displayed an emission peak positioned at 304 nm when excited at 280 nm.…”

“…Nanocarrier matrices can efficiently shield the drug/nutraceutical compounds via encapsulating them in a suitable membrane relying on their either hydrophilic/hydrophobic nature (incorporation, dispersion, or even absorption) or via covalent linking (Babazadeh, Vahed, & Jafari, 2020;Cho, Wang, Nie, & Shin, 2008;Rakotoarisoa, Angelov, Garamus, & Angelova, 2019;Rostamabadi, Falsafi, & Jafari, 2019a. Fundamentally, these nanocarriers have been developed to address the blind spots in conventional delivery methods of bioactive agents (Blanco, Shen, & Ferrari, 2015;Wei, Li, et al, 2020; Wei, Sun, Dai, Zhan, & Gao, 2018).…”

“…Fundamentally, these nanocarriers have been developed to address the blind spots in conventional delivery methods of bioactive agents (Blanco, Shen, & Ferrari, 2015; Wei, Li, et al., 2020; Wei, Sun, Dai, Zhan, & Gao, 2018). Although modern vehicles typically release the loaded molecules in a slow manner and longer periods of time.…”

“…Although modern vehicles typically release the loaded molecules in a slow manner and longer periods of time. The size diminution of encapsulation tools offers several bioadhesive improvement properties, that is, enhanced adhesive power and sustained gastrointestinal (GI) transit time, providing a greater bioavailability of nutraceutical components (Amsalem et al., 2017; Arnon‐Rips, Porat, & Poverenov, 2019; Falsafi, Rostamabadi, et al, 2020; Wei, Zhang,et al., 2019; Wei, Yang et al., 2020). In virtue of this manner, nanocarriers can be utilized to render a site‐specific delivery by promoting the controlled/sustained release mechanism of therapeutic agents at the proper place and time.…”