Influence of Ca2+ and substance P on the (Ca mg) ATPase (ec 3.6.1.3) activity of synaptosomes from different areas of rat brain

Lachowicz, Lilla; Janiszewska, Grażyna; R, Wojtkowiak

doi:10.1016/0020-711x(84)90109-5

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimulating effect of SP was observed on Na + -K + ATPase activity (Catalan et al 1987). SP was also observed to increase the activity of Ca 2+ -Mg 2+ ATPase of synaptosomes and others implicated its role in maintenance of Ca 2+ concentrations in nerve terminals (Lachowicz et al 1984).…”

Section: Discussionmentioning

confidence: 85%

Membrane Associated Functions of Neurokinin B (NKB) on Aβ (25–35) Induced Toxicity in Aging Rat Brain Synaptosomes

et al. 2006

View full text Add to dashboard Cite

The effect of different concentrations (0.1-5 microM) of neurokinin B (NKB) and Abeta (25-35) on acetylcholine esterase (AChE), Na(+)-K(+) ATPase and membrane fluidity (DPH anisotropy) were investigated in rat brain synaptosomes of 3, 9, 18 and 30 months old. An age dependent decrease was observed for all the three parameters studied. An in vitro incubation of isolated brain synaptosomes with Abeta (25-35) showed toxic effects on all the parameters studied and the peptide had concentration and age dependent effects, while NKB showed stimulating effect on the parameters and the combined NKB+Abeta (25-35) incubations showed a partial reversal effect as compared to the Abeta (25-35) alone. Thus, the results suggest a membrane mediated function for NKB and its role in neuromodulation, neuroprotection and antioxidant property against Abeta (25-35) induced toxicity in aging brain functions.

show abstract

Section: Discussionmentioning

confidence: 85%