Influence of blood donation on the incidence of plateau at $$ \dot{V}{\text{O}} $$ V ˙ O 2max

Gordon, Dan; Wood, Madeleine; Porter, A. R.; Vetrivel, Vignesh; Gernigon, Marie; Caddy, Oliver; Merzbach, Viviane; Keiller, Don; Baker, James H.; Barnes, Richard

doi:10.1007/s00421-013-2743-3

Cited by 18 publications

(18 citation statements)

References 35 publications

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“…Special attention was given to the effects of acute manipulations of the cardiovascular oxygen transport system on V O 2max . In fact V O 2max is lower in acute anaemia than in normaemia (Burnley et al 2006;Celsing et al 1987;Gledhill et al 1999;Gordon et al 2014;Krip et al 1997;woodson et al 1978) and is higher in acute polycythaemia than in normaemia (Berglund and Hemmingsson 1987;Buick et al 1980;Celsing et al 1987;Ekblom and Huot 1972;Ekblom et al 1976;Gledhill et al 1999;Sawka et al 1987;Spriet et al 1986;thomson et al 1982;turner et al 1993), also when polycythaemia has been induced by erythropoietin administration (Audran et al 1999;Berglund and Ekblom 1991;Russell et al 2002;thomsen et al 2007). V O 2max is lower also during carbon monoxide breathing than during air breathing (Ekblom and Huot 1972;Ekblom et al 1975;Horvath et al 1988;Pirnay et al 1971;vogel and Gleser 1972) and during cold exposure than at thermoneutral temperature (Bergh and Ekblom 1979;Kruk et al 1991;McArdle et al 1976;Pirnay et al 1977).…”

Section: Descriptive Physiology Of V O 2maxmentioning

confidence: 99%

Maximal oxygen consumption in healthy humans: theories and facts

Ferretti

2014

Eur J Appl Physiol

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This article reviews the concept of maximal oxygen consumption ([Formula: see text]) from the perspective of multifactorial models of [Formula: see text] limitation. First, I discuss procedural aspects of [Formula: see text] measurement: the implications of ramp protocols are analysed within the theoretical work of Morton. Then I analyse the descriptive physiology of [Formula: see text], evidencing the path that led to the view of monofactorial cardiovascular or muscular [Formula: see text] limitation. Multifactorial models, generated by the theoretical work of di Prampero and Wagner around the oxygen conductance equation, represented a radical change of perspective. These models are presented in detail and criticized with respect to the ensuing experimental work. A synthesis between them is proposed, demonstrating how much these models coincide and converge on the same conclusions. Finally, I discuss the cases of hypoxia and bed rest, the former as an example of the pervasive effects of the shape of the oxygen equilibrium curve, the latter as a neat example of adaptive changes concerning the entire respiratory system. The conclusion is that the concept of cardiovascular [Formula: see text] limitation is reinforced by multifactorial models, since cardiovascular oxygen transport provides most of the [Formula: see text] limitation, at least in normoxia. However, the same models show that the role of peripheral resistances is significant and cannot be neglected. The role of peripheral factors is greater the smaller is the active muscle mass. In hypoxia, the intervention of lung resistances as limiting factors restricts the role played by cardiovascular and peripheral factors.

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Section: Descriptive Physiology Of V O 2maxmentioning

confidence: 99%

Maximal oxygen consumption in healthy humans: theories and facts

Ferretti

2014

Eur J Appl Physiol

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“…The incidence of plateau at _ VO 2max was established according to previously established criteria (Δ _ VO 2 ≤1Á5 ml Á kg À1 Á min À1 ) (Gordon et al, 2013b(Gordon et al, , 2015; additionally, the secondary criteria were calculated together with means and standard deviations for all numerically derived data. As the data were shown to be both normally distributed and homogenous through the application of Levene's test of homogeneity, a repeated measures ANOVA was applied to the data and regression slope of the _ VO 2 response and all sundry data to address differences across menstrual cycle phases within n-OCP and OCP groups.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have eluded to the notion that the manifestation of a plateau in _ VO 2 at the point of volitional exhaustion is a function of the availability and regulation of the finite anaerobic reserves, hence the magnitude of the anaerobic capacity (Wagner, 2000;Hawkins et al, 2007;Gordon et al, 2011). Support for this association was demonstrated through an inverse relationship between the magnitude of the anaerobic capacity as expressed through a surrogate measure (maximally accumulated oxygen deficit) and the Δ _ VO 2 during the final 60 s of an incremental stress test (Gordon et al, 2011) and a non-significant response for Δ _ VO 2 despite a reduction in blood volume of~450 cm 3 (Gordon et al, 2013b). Previous works have alluded to a potential 'anaerobic substrate metabolism' enhancement during LUT for both muscle glycogen retention and concentration (Nicklas et al, 1989); however, of note was the non-significant change in muscle glycogen utilization when comparing FOL to LUT (De Bryn-Prevost et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

The effects of menstrual cycle phase on the incidence of plateau at and associated cardiorespiratory dynamics

Gordon

Scruton

Barnes

et al. 2017

Clin Physio Funct Imaging

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The purpose of this study was to examine the effect of menstrual cycle phase on maximal oxygen uptake (V˙O2max) and associated cardiodynamic responses. A total of 16 active females volunteered of which n = 10 formed the non-oral contraceptive pill group (n-OCP), displaying a regular menstrual cycle of 28·4 ± 2·2 days (age 20·6 ± 1·6 years, height 169·9 ± 6·4 cm, mass 68·7 ± 7·9 kg) and n = 6 formed the oral contraceptive pill group (OCP) (monophasic pill) (age 21·7 years ± 2·16, height 168·1 cm ± 6·8 cm, mass 61·6 ± 6·8 kg). Each completed four incremental exercise tests for determination of V˙O2max, cardiac output, stroke volume and heart rate. Each test was completed according to the phases of the menstrual cycle as determined through salivary analysis of 17-β oestrodiol and progesterone. Non-significant differences were observed for V˙O2max across phases and between groups (P>0·05) with additional non-significant differences for Q˙max, HR and SV between groups. For ∆ V˙O2 during the final 60 s of the V˙O2max trial, significant differences were observed between OCP and n-OCP (P<0·05) with OCP showing zero V˙O2 plateaus in three pseudo-phases. Significant difference observed for a-vO n-OCP between premenstruation and menstruation at 30-100% V˙O2max (P<0·05). Data suggest that the V˙O2 -plateau is effected by monophasic oral contraceptive pill, furthermore these data imply that V˙O2max test outcome is independent of menstrual cycle phase but caution should be applied when evaluating maximal oxygen uptake in females who are administered a monophasic oral contraceptive pill.

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“…As before, the Micro-Stat analyser was calibrated, as per manufacturers' instructions, before analysis, with all samples being measured immediately upon collection. 10 To determine O 2max and associated cardio-respiratory responses, participants completed an incremental exercise stress test, to volitional exhaustion, on a precalibrated cycle ergometer, using a ramp rate of 0.42 W . s -1 , with a starting resistance of 50 W (females), 100 W (males), at a minimum cadence of 60 rpm.…”

Section: Following Institutional Ethical Approval (Faculty Of Science and Engineering Researchmentioning

confidence: 99%

The plateau at V˙ O2max is associated with anaerobic alleles

Keiller

Gordon

2020

Journal of Science and Medicine in Sport

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Objectives: This study tests the hypothesis that individuals who achieve a plateau at O 2max ( O 2plat ) are more likely to possess alleles, associated with anaerobic capacity, than those who do not. Design: A literature survey, physiological testing and genetic analysis was used to determine any association between the aerobic and anaerobic polymorphisms of 40 genes and O 2plat . Methods: 34, healthy, Caucasian volunteers, completed an exercise test to determine O 2max, and O 2plat . 28 of the volunteers agreed to DNA testing and 26 were successfully genotyped. A literature search was used to determine whether the 40 polymorphisms analysed were associated with aerobic, or anaerobic exercise performance. Results: The literature survey enabled classification of the 40 target alleles as aerobic [11], anaerobic [24], or having no apparent association (NAA) [5] with exercise performance. It also found no previous studies linking a genetic component with the ability to achieve O 2plat . Independent t-tests showed a significant difference (p < 0.001) in the ability to achieve O 2plat , but no other measured physiological variable was significantly different. Pearson's χ 2 testing demonstrated a highly significant association (p = 0.008) between anaerobic allele frequency and O 2plat , but not with O 2max . There was no association between aerobic alleles and O 2plat , or O 2max .Finally there were no significant differences in the allelic frequencies, observed in this study and those expected of Northern and Western European Caucasians. Conclusion:These results support the hypothesis that the ability to achieve O 2plat is associated with alleles linked to anaerobic exercise capacity.

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Influence of blood donation on the incidence of plateau at $$ \dot{V}{\text{O}} $$ V ˙ O 2max

Abstract: These data suggest that plateau at VO2max is unaffected by O2 availability lending support to the notion of the plateau being dependent on the anaerobic capacity and the classically orientated concept of VO2max.

Cited by 18 publications

References 35 publications

Maximal oxygen consumption in healthy humans: theories and facts

Maximal oxygen consumption in healthy humans: theories and facts

The effects of menstrual cycle phase on the incidence of plateau at and associated cardiorespiratory dynamics

The plateau at V˙ O2max is associated with anaerobic alleles

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