Arch Pediatr Adolesc Med
 1981
DOI: 10.1001/archpedi.1981.02130340030011
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Influence of Age and Sex on Serum Complement Components in Children

Barbara Roach
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Cited by 34 publications

(12 citation statements)
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“…In addition, single-nucleotide polymorphisms (SNP) can strongly affect the concentration and/or function of various complement proteins, as have been well-documented for e.g., MBL ( 45 , 46 ). Yet, limited studies have investigated the influence of sex and age on the complement system ( 47 – 49 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, data on the influence of sex on the complement system remains limited. A study by Roach et al demonstrated that in children (age range 1–19 years) there were differences in several complement components between boys and girls ( 49 ). However, the differences found in this study were age-dependent.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In addition, single-nucleotide polymorphisms (SNP) can strongly affect the concentration and/or function of various complement proteins, as have been well-documented for e.g., MBL ( 45 , 46 ). Yet, limited studies have investigated the influence of sex and age on the complement system ( 47 – 49 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, data on the influence of sex on the complement system remains limited. A study by Roach et al demonstrated that in children (age range 1–19 years) there were differences in several complement components between boys and girls ( 49 ). However, the differences found in this study were age-dependent.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The results of the study agreed with another study that found that C5 was higher in males and less by 14% in females, and the concentration was high in the elderly (P < 0.001) (36). The variation in ratios between females and males is attributed to genetic factors or factors Hormonal, as hormones influence the mechanism of the immune reaction (37)Roach et al is clear that there are significant differences between the levels of concentrations of complement system proteins in young people (1-19 years) and between males and females (38).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“… 30 The complement component's serum concentration positively correlates with the individual's age. 31 Lower complement concentration may lead to prolonged gametocyte survival in the lower age group. 32 Reports from different continents showed contrasting cytokine production in the pediatric malaria population.…”
Section: Methodsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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