Influence of admixed polymers on the metronidazole release from hydroxypropyl methylcellulose matrix tablets

Traconis, Norma; Rodriguez, Raúl D.; Campos, María Elena; Villafuerte, Leopoldo

doi:10.1016/s0031-6865(97)00007-1

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…Manipulation of polymers as matrices has been a popular mean to control release of drugs (1,2). Matrices can be prepared via direct compression or a wet granulation process (2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…Matrices can be prepared via direct compression or a wet granulation process (2)(3)(4)(5)(6)(7). Materials generally used in forming matrices are polymers, which can be organized into hydrophobic and hydrophilic groups.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, matrices made of hydrophilic polymers such as hydroxypropylmethylcellulose derivatives swell and form a gelled matrix upon contact with water, and thus drug release is primarily governed by diffusion through the gelled matrix (4). Polymers selected from either the same or different groups can be admixed to modify the rate and mechanism of drug release from matrices (2,3). In addition, drug release from matrices may be tuned by adjustment of polymer concentration or/and addition of other excipients (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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Abstract. This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model drug. HPMC-and EC-based matrices with varying amounts (0-40%w/w) of resin incorporation were prepared by a direct compression. Matrix properties including diameter, thickness, hardness, friability, surface morphology and drug release were evaluated. The obtained matrices were comparable in diameter and thickness regardless of the amount of resin incorporation. Increasing the incorporated resin decreased the hardness of HPMC-and EC-based matrices, correlating with the degree of rupturing on the matrix surfaces. The friability of HPMC-based matrices increased with increasing the incorporated resin, corresponding to their decreased hardness. In contrast, the EC-based matrices showed no significant change in friability in spite of decreasing hardness. The incorporated resin differently influenced DPH release from HPMC-and EC-based matrices in deionized water. The resin further retarded DPH release from HPMC-based matrices due to the gelling property of HPMC and the ion exchange property of the resin. In contrast, the release from EC-based matrices initially increased because of the disintegrating property of the resin, but thereafter declined due to the complex formation between released drug and dispersed resin via the ion exchange process. The release in ionic solutions was also described. In conclusion, the incorporated resin could alter the release and physical properties of matrices.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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“…Among the technological variables that influence the release from hydrophilic matrices, the use of polymer blends is a potential way of achieving the desired release properties [24]. Mixtures of different proportions of polymers with different permeation characteristics could provide a wide variety of release rates of a drug, due to changes in diffusivity of the drug through the polymeric barrier [25].…”

Section: Resultsmentioning

confidence: 99%

Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets

Aguilar-López

Villafuerte-Robles

2016

Journal of Pharmaceutics

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Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine (NH3+) group of chitosan and the carboxylate (COO−) group of Carbopol. In situ polyelectrolyte complexes formations based on the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The aim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could modify their technological performance in captopril tablets. The drug and excipients were evaluated as mixtures of powders and tablets. The mixtures with captopril contained Carbopol 974P NF, chitosan, or a 1 : 1 mixture thereof with polymer proportions of 10%, 20%, and 30%. The evaluated parameters were the powder flow rate, the powder compressibility index, and the compactibility and release behavior of the tablets. The observed technological behavior points out to a greater interaction between the particles of polymers with different charge than between particles of the individual polymers. This produces more coherent matrices restricting more efficiently the drug dissolution, more coherent tablets with higher compactibility, and less flowing powder mixtures. All this, however, requires additional investigation to confirm the current results.

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“…[12][13][14][15][16][17] In one of our earlier investigations, 14 evaluation of commercially available SR tablets of DS from the Indian market revealed a large variation in their rate and extent of DS release. So, in an effort to achieve improved, controlled-and prolonged-release of DS, various formulations of DS have been prepared in the present study including fabricated matrix (FM) tablets using single polymer and admixed polymers, 18 osmotic matrix (OM) tablets, 19 and osmotic pump (OP) tablets. 20,21 A comparative evaluation has been made among all these formulations and with commercial tablets.…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro and in vivo evaluation of matrix, osmotic matrix, and osmotic pump tablets for controlled delivery of diclofenac sodium

Rani

Mishra

2004

AAPS PharmSciTech

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The aim of this investigation was preparation and comparative evaluation of fabricated matrix (FM), osmotic matrix (OM), and osmotic pump (OP) tablets for controlled delivery of diclofenac sodium (DS). All formulations were evaluated for various physical parameters, and in vitro studies were performed on USP 24 dissolution apparatus II in pH 7.4 buffer and distilled water. In vivo studies were performed in 6 healthy human volunteers; the drug was assayed in plasma using HPLC, and results were compared with the performance of 2 commercial tablets of DS. Various pharmacokinetic parameters (ie, C max , T max , area under the curve [AUC 0-24 ], and mean residence time) and relative bioavailability were compared. All fabricated formulations showed more prolonged and controlled DS release compared with commercial tablets studied. The OM and OP tablets, however, performed better than the matrix tablets. The rate and extent of drug release from FM1 matrix tablets (single polymer) was significantly different from that of FM2 (admixed polymers). Type of porosigenic agents and osmogens also influenced the drug release. Analysis of in vitro data by regression coefficient analysis revealed zero-order release kinetics for OM and OP tablets, while FM tablets exhibited Higuchi kinetics. In vivo results indicated prolonged blood levels with delayed peak and improved bioavailability for fabricated tablets compared to commercial tablets. It was concluded that the osmotic matrix and osmotic pump tablets could provide more prolonged, controlled, and gastrointestinal environmentalindependent DS release that may result in an improved therapeutic efficacy and patient compliance.

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Influence of admixed polymers on the metronidazole release from hydroxypropyl methylcellulose matrix tablets

Cited by 19 publications

References 12 publications

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets

Comparative in vitro and in vivo evaluation of matrix, osmotic matrix, and osmotic pump tablets for controlled delivery of diclofenac sodium

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