Influence of admixed carboxymethylcellulose on release of 4-aminopyridine from hydroxypropyl methylcellulose matrix tablets

Juárez, Haydee; Rico, Giovanna; Villafuerte, Leopoldo

doi:10.1016/s0378-5173(01)00583-x

Cited by 37 publications

(10 citation statements)

References 18 publications

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“…The polymers are widely used in the preparation of controlled release matrices due to their simplicity, safety and it should be economical use [1][2][3][4]. Among these polymers celluloses have been extremely popular in controlling the release rate of soluble drug from solid dosage form.…”

Section: Introductionmentioning

confidence: 99%

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

Alhmoud¹

2016

Adv. Biomed. Pharma.

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The effect of the hydrophilic polymers such as sodium carboxymethyl cellulose, (NaCMC) and the hydrophobic polymers such as Eudragit RL100 and Eudragit RS 100 on the dissolution and the release rate of drug when prepared as controlled release matrices were studied. Tablets were prepared by a direct compression technique. The dissolution tests were performed by both the basket and the paddle methods. In the present study the acrylic resins Eudragit RS 100 and Eudragit RL 100 are separately mixed with the anionic and hydrophilic polymer NaCMC and the other excipients in an attempt to prepare controlled release matrices and to investigate the effect of the charge and composition of these polymers on the drug release. Also the research will study the effect of the pH of the dissolution medium, and the storage of the matrices at different temperatures, on the release rate of the drug. It was found that percent, charge of the polymers, pH of the dissolution medium and storage of matrices at different temperatures affect the release rate of the drug. The experiments were performed in vitro and the data obtained were plotted according to four kinetic models to study the release kinetic. These models were zero order release, first order release, Higuchi equation, and Korsmeyer equation. Zero order release was observed in the formulation with a high percent of the hydrophilic polymers, while high percent of hydrophobic polymers didn't show zero order release and the drug was liberated in a less time from the matrices.

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Section: Introductionmentioning

confidence: 99%

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

Alhmoud¹

2016

Adv. Biomed. Pharma.

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“…These systems are attractive approaches from economic as well as process development view of point [6][7][8][9] . A sustained release matrix tablet consists of a compressed compact containing a mixture of one or more bioactive agent (s) with one or more matrix former (s), which retards drug release.…”

Section: Introductionmentioning

confidence: 99%

Low level maize starch and sodium lauryl sulphate as release modifiers in carbopol 941 capsule matrix

Emeje¹,

Ofoefule²

2009

Int J Green Pharm

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“…In one word, the addition of CMC-Na decreased the release rate, shortened the initial release disparity and improved the concordance of felodipine and metoprolol tartrate. It was reported that the addition of CMC to HPMC with long chains could increase the average viscosity, change the viscoelastic and mechanical properties of mixed polymer gels and thereby decrease evidently the drug release36 . The above alteration may be attributed to stronger hydrogen bonding between the carboxyl groups on CMC and the hydroxyl groups on the non-ionic HPMC and the possible formation of an interpenetrating network37 .…”

mentioning

confidence: 99%

Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology

Zhao¹,

Yu²,

Liu³

et al. 2016

Drug Development and Industrial Pharmacy

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The synchronous sustained-release of two drugs was desired urgently for patients needing combination therapy in long term. However, sophisticated technologies were used generally to realize the simultaneous delivery of two drugs especially those with different physico-chemical properties. The purpose of this study was to obtain the concurrent release of felodipine and metoprolol tartrate, two drugs with completely different solubilities, in a simple monolithic osmotic pump system (FMOP). Two types of blocking agents were used in monolithic osmotic pump tablets and the synchronous sustained-release of FMOP was acquired in vitro. The tablets were also administered to beagle dogs and the plasma levels of FMOP were determined by HPLC-MS/MS. The pharmacokinetic parameters were calculated using a non-compartmental model. Cmax of both felodipine and metoprolol from the osmotic pump tablets were lower, tmax and mean residence time of both felodipine and metoprolol from the osmotic pump tablets were longer significantly than those from immediate release tablets. These results verified prolonged release of felodipine and metoprolol tartrate from osmotic pump formulations. The similar absorption rate between felodipine and metoprolol in beagles was also obtained by this osmotic pump formulation. Therefore, it could be supposed that the accordant release of two drugs with completely different solubilities may be realized just by using monolithic osmotic pump technology.

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Influence of admixed carboxymethylcellulose on release of 4-aminopyridine from hydroxypropyl methylcellulose matrix tablets

Cited by 37 publications

References 18 publications

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

Low level maize starch and sodium lauryl sulphate as release modifiers in carbopol 941 capsule matrix

Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology

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