2018
DOI: 10.3389/fgene.2018.00540
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Abstract: To determine the role of A disintegrin and metalloproteinase 10 (ADAM10) in genetic susceptibility to Alzheimer’s disease (AD) in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for the rs514049A/C and rs653765C/T polymorphisms in the ADAM10 promoter using the SNaPshot technique. We also examined the potential impact of these polymorphisms on the plasma level of soluble receptor for advanced glycation end products (sRAGE), a decoy receptor whose reduction has been associa… Show more

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Cited by 14 publications
(15 citation statements)
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References 63 publications
(73 reference statements)
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“…The inconsistent results might be due to the variations of sample sizes, detection methods, and techniques of sample disposal and storage in those studies. In particular, as altered plasma ADAM10 levels and genetic ADAM10 variants have also been observed in AD, 8,15,26,38 they are both likely to have low diagnostic capacity in PD. Plasma ADAM10 levels or genetic ADAM10 variants may prove useful in combination with other diagnostic items appropriate for PD.…”
Section: Discussionmentioning
confidence: 99%
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“…The inconsistent results might be due to the variations of sample sizes, detection methods, and techniques of sample disposal and storage in those studies. In particular, as altered plasma ADAM10 levels and genetic ADAM10 variants have also been observed in AD, 8,15,26,38 they are both likely to have low diagnostic capacity in PD. Plasma ADAM10 levels or genetic ADAM10 variants may prove useful in combination with other diagnostic items appropriate for PD.…”
Section: Discussionmentioning
confidence: 99%
“…26,37 One study containing 10 people with mild cognitive impairments (MCIs), 25 AD patients, and 10 healthy controls (HCs) in a Brazilian population, found that plasma ADAM10 levels were significantly higher in AD patients than in HCs, while the concentration of plasma ADAM10 in PD patients remains unknown. 38 variants have also been observed in AD, 8,15,26,38 However, the role of ADAM10 in the occurrence and development of PD is unclear. Some studies indicated that cleavage dysfunction in ADAM10 not only affected APP processing but also gave rise to changes in microglial morphology and functions, resulting in profound defects in microglial synaptic engulfment and synapse elimination.…”
Section: Discussionmentioning
confidence: 99%
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“…AGER is a highly polymorphic gene [ 44 ], with some variants affecting levels of both the cleaved form of sRAGE and esRAGE [ 30 ]. Furthermore, sRAGE levels may be influenced by polymorphisms in other genes, for example in ADAM10 [ 45 ]. Finally, levels of both sRAGE isoforms are strongly affected by ethnicity, being lower in people from Afro-Caribbean and Hispanic origin than in Caucasians [ 26 , 30 , 35 ].…”
Section: The Sources Of Soluble Rages and Their Regulationmentioning
confidence: 99%
“…These proteases are characterized by a modular domain structure consisting of an N-terminal signal sequence followed by a pro-domain, a metalloprotease (catalytic) domain, a dissociation domain, an epidermal growth factor-like (cysteine-rich) domain, a single transmembrane domain and a cytoplasmic fraction (40,41). ADAM10 is involved in the shedding of a number of substrates that are critical for cancer progression, neurological and vascular diseases, degenerative diseases, and the morphogenesis and the remodeling of some tissues (42)(43)(44)(45)(46). A recent study on pulmonary fibrosis revealed that ADAM10 is the major metalloproteinase in human lung fibroblasts and increases in its expression can continue to activate fibroblast proliferation and muscle formation to promote organ fibrosis (47).…”
Section: Discussionmentioning
confidence: 99%