Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food

Wei, Alfreda; Fascetti, Andrea J.; Liu, K. J.; Villaverde, Cecilia; Green, A. S.; Manzanilla, Edgar García; Havel, Peter J.; Ramsey, Jon J.

doi:10.1111/j.1439-0396.2010.01062.x

Cited by 24 publications

(27 citation statements)

References 33 publications

(39 reference statements)

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“…Our results are in agreement with other studies supporting the correlation with adiposity with increased leptin concentrations in overweight and obese cats and increases in cats undergoing weight gain [19, 37]. Similar to other studies [31, 38], fasting leptin concentrations were also not affected by feeding a high protein diet which is likely due to the maintenance of a stable body weight in our subjects.…”

Section: Discussionsupporting

confidence: 93%

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

et al. 2017

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BackgroundDyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats. Client-owned cats were recruited and assigned into 3 study groups: lean, overweight and diabetic. Fasting blood samples were analyzed in lean, overweight and diabetic cats at baseline and 4 weeks after consumption of high protein/low carbohydrate standardized diet.ResultsSerum concentrations of triglycerides were greater in diabetics at baseline and were increased in both diabetic and overweight cats at 4 weeks. Plasma leptin concentrations were greater in diabetic and overweight at baseline and 4 weeks, whereas adiponectin was lower in diabetics compared to lean and overweight cats at baseline and 4 weeks. Diabetics had greater baseline plasma glucagon concentrations compared to lean, lower adropin than overweight at 4 weeks, and lower IL-12 concentrations at 4 weeks than baseline.ConclusionsOur results suggest that feline obesity and diabetes mellitus are characterized by hypertriglyceridemia and hyperleptinemia; however, diabetic cats have significantly lower adiponectin and adropin compared to overweight cats. Thus, despite having similar body condition, overweight and diabetic cats have differential circulating concentrations of adiponectin and adropin.

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Section: Discussionsupporting

confidence: 93%

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

et al. 2017

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“…The lower blood glucose concentrations in our cats fed the lower carbohydrate diets is consistent with previous findings, however, others have not reported differences, largely because of the methodology used, or the difference in carbohydrate content was not as great . It was not surprising that we found no differences in glucose tolerance test results between the diets, because the glucose tolerance test is performed after a 24‐hour fast, and the glucose load is the same for all cats.…”

Section: Discussionsupporting

confidence: 91%

Effect of Dietary Carbohydrate, Fat, and Protein on Postprandial Glycemia and Energy Intake in Cats

Farrow

Rand

Morton

et al. 2013

Veterinary Internal Medicne

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“…When compared with diets containing a lower protein content, high‐protein (>40% of ME) diets have been reported to maintain LBM while enhancing the loss of fat mass (FM) in dogs (Hannah, ; Diez et al., ) and cats (Nguyen et al., ; Laflamme and Hannah, ; Vasconcellos et al., ). Similar results have also been reported in obese cats fed a HP diet ad libitum (Wei et al., ). Feeding a HP diet was also reported to decrease the energy restriction needed for weight loss in obese cats and resulted in an increase in their energy requirements during weight maintenance (Vasconcellos et al., ).…”

Section: Introductionsupporting

confidence: 88%

“…In contrast, cats on the HP diet either did not exhibit changes in hormones indicative of improved insulin sensitivity or the observed responses in hormone concentrations were blunted in comparison with the MP group. Other reports (Hoenig et al., ; Wei et al., ) have found that dietary protein intake does not affect insulin sensitivity in cats.…”

Section: Discussionmentioning

confidence: 82%

Influence of dietary protein level on body composition and energy expenditure in calorically restricted overweight cats

Courtis

Wei

Kass

et al. 2014

Animal Physiology Nutrition

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High-protein (HP) diets help prevent loss of lean mass in calorie-restricted (CR) cats. However, it is not entirely known whether these diets also induce changes of energy expenditure during periods of CR. To investigate this issue, sixteen overweight cats were fed either a high-protein [(HP), 54.2% of metabolizable energy (ME)] or a moderate-protein [(MP), 31.5% of ME] diet at 70% of their maintenance energy intakes for 8 weeks, and energy expenditure, energy intake, body weight and composition, and serum metabolites and hormones were measured. While both groups of cats lost weight at a similar rate, only cats eating the HP diet maintained lean mass during weight loss. Indirect respiration calorimetry measurements revealed that both total and resting energy expenditure (kcal/d) significantly decreased during weight loss for both treatment groups. However, only cats eating the MP diet exhibited significant decreases of total and resting energy expenditures after energy expenditure was normalized for body weight or lean mass. Results from this study suggest that in addition to sparing the loss of lean mass, feeding HP diets to overweight cats in restricted amounts may be beneficial for preventing or minimizing decreases of mass-adjusted energy expenditure during weight loss.

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Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food

Cited by 24 publications

References 33 publications

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

Effect of Dietary Carbohydrate, Fat, and Protein on Postprandial Glycemia and Energy Intake in Cats

Influence of dietary protein level on body composition and energy expenditure in calorically restricted overweight cats

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