Influence of 19-Nortestosterone Cyclopentylpropionate on Urinary Nitrogen of Castrate Male Rat

Stafford, Robert O.; Bowman, Barbara J.; Olson, Kenneth J.

doi:10.3181/00379727-86-21086

Cited by 24 publications

(2 citation statements)

References 2 publications

(2 reference statements)

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“…In this study, DHT and DHTP given to castrated, adult, male rats resulted in significant gains in body weight. This may suggest an action of DHT on central neural sites regulating feeding behaviour, although it may also influence anabolic processes (Stafford, Bowman & Olson, 1954) and fat deposition.…”

Section: Discussionmentioning

confidence: 96%

The COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-Ol-3-One PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

Feder¹

1971

Journal of Endocrinology

140

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5\g=a\-Androstan-17\g=b\-ol-3-one in its free or in its propionate form was injected systemically (125\g=m\g/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight.In contrast, testosterone propionate (125 \g=m\g/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males.These effects may have been due in part to conversion of testosterone to 5\g=a\-androstan-17\g=b\-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

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Section: Discussionmentioning

confidence: 96%

The COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-Ol-3-One PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

Feder¹

1971

Journal of Endocrinology

140

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“…Male rats, averaging 160 g body weight were placed in metabolism cages (2,/cage) and fed Ingle's liquid medium carbohydrate diet ad Zibitum (4). Male rats, averaging 160 g body weight were placed in metabolism cages (2,/cage) and fed Ingle's liquid medium carbohydrate diet ad Zibitum (4).…”

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confidence: 99%

Steroid-Induced Adrenal-Pituitary Hypofunction II

Ej¹

1956

Experimental Biology and Medicine

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Male Sex Hormones, Analogs, and Antagonists

Brueggemeier

2010

Burger's Medicinal Chemistry and Drug Discovery

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The steroid testosterone is the major circulating sex hormone of the male and serves as the prototype for the androgens, the anabolic agents, and androgen antagonists. The endogenous androgens are biosynthesized from cholesterol in various tissues in the body; the majority of the circulating androgens are made in the testes under the stimulation of the gonadotropin luteinizing hormone ( LH ). The reduction of testosterone to dihydrotestosterone is necessary for the androgenic actions of testosterone in many androgen target tissues such as the prostate; the oxidation of testosterone by the enzyme aromatase produces estrogens. The androgenic actions of testosterone and dihydrotestosterone are due to their binding to the androgen receptor, followed by nuclear localization, dimerization of the receptor complex, and binding to a specific DNA sequence. This binding of the homodimer to the androgen response element leads to gene expression, stimulation or repression of the synthesis of new mRNA, and subsequent protein biosynthesis. The synthetic androgens and anabolics were prepared to impart oral activity to the androgen molecule, to separate the androgenic effects of testosterone from its anabolic effects, and to improve upon its biological activities. Novel nonsteroidal androgens, termed selective androgen receptor modulators, were developed to impart agonist activity in selective tissues. Drug preparations are used for the treatment of various androgen‐deficient diseases, for the therapy of diseases characterized by muscle wasting and protein catabolism, for postoperative adjuvant therapy, and for the treatment of certain hormone‐dependent cancers. The two major categories of androgen antagonists are the antiandrogens, which block interactions of androgens with the androgen receptor, and the inhibitors of androgen biosynthesis and metabolism. Such compounds have therapeutic potential in the treatment of acne, virilization in women, hyperplasia and neoplasia of the prostate, and baldness and male contraception.

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Influence of 19-Nortestosterone Cyclopentylpropionate on Urinary Nitrogen of Castrate Male Rat

Cited by 24 publications

References 2 publications

The COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-Ol-3-One PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

The COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-Ol-3-One PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

Steroid-Induced Adrenal-Pituitary Hypofunction II

Male Sex Hormones, Analogs, and Antagonists

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