2017
DOI: 10.18632/oncotarget.23208
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Abstract: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commo… Show more

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Cited by 2,768 publications
(1,793 citation statements)
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References 162 publications
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“…These include NF‐κB which is a transcription factor regulating gene expression of inflammatory molecules. Upon stimulation, phosphorylated‐IκB promotes its protease‐dependent uubiquitination which subsequently lead NF‐κB complex in cytosol free to enter the nucleus where it can “turn on” the expression of specific genes . To explore whether DSW influenced NF‐κB signaling, the protein levels of IKK, IκB in the cytosolic fraction and NF‐κB in the nuclear fraction in the heart tissues were analyzed by immunoblotting.…”
Section: Resultsmentioning
confidence: 99%
“…These include NF‐κB which is a transcription factor regulating gene expression of inflammatory molecules. Upon stimulation, phosphorylated‐IκB promotes its protease‐dependent uubiquitination which subsequently lead NF‐κB complex in cytosol free to enter the nucleus where it can “turn on” the expression of specific genes . To explore whether DSW influenced NF‐κB signaling, the protein levels of IKK, IκB in the cytosolic fraction and NF‐κB in the nuclear fraction in the heart tissues were analyzed by immunoblotting.…”
Section: Resultsmentioning
confidence: 99%
“…As a consequence, genetic and epigenetic changes in various proto‐oncogenes and tumor‐suppressor genes have been detected . A relatively stable epigenetic change may lead to the enhancement of tumorigenesis aspects such as faster cellular proliferation, stimulation of greater angiogenesis, and inhibition of apoptosis …”
Section: The Role Of Infection and Inflammatory Mediators In Cancer Dmentioning
confidence: 99%
“…The inflammatory response is fundamental for removing injurious stimuli (including infectious and noninfectious agents and cell damage) and initiating healing processes by triggering a cascade of cytokines and growth factors and increasing immune cell activation and infiltration (Chen et al, ). However, it is clear that prolonged or excessive inflammatory responses can induce considerable tissue damage (e.g., scarring and fibrosis) and can be highly detrimental to the host.…”
Section: Immune Homeostasis Versus Immune‐related Diseasesmentioning
confidence: 99%