Inflammatory pseudotumor of spleen: a case report

Ugalde, Paul; Bernardo, Carmen García; Granero, P.; Miyar, A.; González, Carmen Martínez; González-Pinto, I; Barneo, L; Vázquez, L

doi:10.1016/j.ijscr.2015.01.014

Cited by 13 publications

(17 citation statements)

References 13 publications

(34 reference statements)

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“…Inflammatory pseudotumors are rare masses of inflammatory cells that can be found in various anatomical areas of the body. 4-7 The name inflammatory pseudotumor was first coined in 1954 by Umiker and Iverson, 8 , 10 and encompasses a spectrum of inflammatory lesions including plasma cell granuloma, plasma cell pseudotumor and myofibroblastic tumor, which are all thought to arise from a similar underlying inflammatory disease process, eventually resulting in a tumor like mass of inflammatory cells. 7 , 8 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…Other etiologies including trauma with secondary focal parenchymal necrosis, chronic infection, low-grade neoplastic processes, vascular causes and immunological derangement have been suggested. 1 , 2 , 4 , 6 , 10 This is still a topic of discussion.…”

Section: Discussionmentioning

confidence: 99%

“… 1-3 , 5-7 Primary splenic IPT is rare; and the precise number of cases is uncertain, with variable numbers reported in the literature since its first description in 1984 by Cotelingam and Jaffe. 1-5 , 7 , 8 The number of cases reported varies between 80 reported in 2008, 1 , 5 , 6 to 114 in the most recent studies; 4 however, the available data is incomplete, and it remains unclear whether all of these cases are primary solitary splenic IPT or whether some of these are cases of secondary splenic involvement, or misdiagnoses of other histologically similar lesions.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Pseudotumor of the Spleen

2015

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Isolated splenic inflammatory pseudotumors (IPT) are extremely rare, typically benign, inflammatory lesions with varied clinical presentations that pose a diagnostic challenge to clinicians due to their similarity in appearance to neoplasms. We present the case of a young woman diagnosed with a splenic IPT following investigation for persistent anemia, raised inflammatory markers, and polyclonal hypergammaglobulinemia, whose symptoms resolved completely following splenectomy. This case highlights the need to consider this diagnosis when evaluating patients with a splenic mass of unknown etiology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammatory Pseudotumor of the Spleen

2015

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“…Inflammatory pseudotumor (IPT) of the spleen is an extremely rare tumor-like lesion with approximately <115 published cases in adults until 2015, and probably not more than 116 cases until year 2017, at the best of our knowledge [1], [2], [3], [4], [5], [6]. This entity was first introduced in 1984 by Cotelingam and Jaffe [1].…”

Section: Introductionmentioning

confidence: 99%

“…This entity was first introduced in 1984 by Cotelingam and Jaffe [1]. It is a lesion composed of proliferated spindle cells with admixed inflammatory cellular component of variable composition including lymphocytes, plasma cells, histiocytes, and granulocytes [1], [2], [3], [4], [5], [6]. Additional studies have demonstrated that spindle cells are in fact myofibroblasts, prompting the designation inflammatory myofibroblastic tumor (IMT) [2].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Pseudotumor/Inflammatory Myofibroblastic Tumor of Spleen – A Case Report

Jovanović

Eftimov

Antović

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Splenic inflammatory pseudotumor (IPT)/inflammatory myofibroblastic tumor (IMT) is a rare pseudotumor/tumor of unknown origin, which is usually benign, although atypical and aggressive cases have been reported. It is a lesion composed of proliferated myofibroblastic cells (hence IMT by some authors) with admixed pleomorphic inflammatory cells of varying proportions. CASE REPORT: Herein, we report a case of 61-year-old male patient with ill-defined abdominal discomfort and no other symptoms and signs. Clinical and imaging investigations revealed a mass in the spleen that was equivocally interpreted as secondary neoplasm, although primary neoplasm of the spleen was not excluded by the radiologists. Splenectomy was performed and on gross examination a well demarcated greyish-livid tumor measuring 3.5 cm × 3 cm × 3 cm was discovered. Microscopic examination showed proliferation of loosely arranged spindle cells admixed with inflammatory cells (histiocytes, lymphocytes, neutrophils, eosinophils, occasional plasma cells, and/or plasmacytoid cells) with varying density and multifocal clustering, multifocal hemorrhage, and fibrinoid-like deposition. We performed additional histochemical and immunohistochemical stainings which were consistent with the diagnosis of IPT/IMT. Next-generation sequencing (TruSight Tumor 15) showed common TP53 polymorphism (c.215C>G; p.Pro72Arg) along with several intronic and synonymous single nucleotide variations (SNVs), as well as five low confidence missense SNVs. Sixteen months after the operation the patient has uneventful follow-up. CONCLUSION: Although the incidence of IPT/IMT is low, awareness of its existence is necessary. The prognosis is favorable following splenectomy in most cases. Careful microscopic examination of the specimen is mandatory, due to possible misdiagnosis. We believe that extensive NGS analysis on archive samples would provide more data about the spectrum of possible genetic changes in lesions like IPM/IMT.

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