Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index

Gonzalez, Macarena B; Lane, Michelle; Knight, Emma; Robker, Rebecca L.

doi:10.1016/j.jri.2018.08.005

Cited by 45 publications

(51 citation statements)

References 61 publications

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“…TAG levels inversely correlated to follicle size (10) and positively correlated to maternal body mass index (BMI) in several independent studies (11,12). TAG accumulation in the FF was also correlated to the levels of adipokines and proinflammatory cytokines in FF (13).…”

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confidence: 96%

A shift in follicular fluid from triacylglycerols to membrane lipids is associated with positive pregnancy outcome

et al. 2019

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Follicular fluid (FF) is a liquid that surrounds the ovum. Its metabolite and, specifically, its lipid content have been associated with oocyte development. To characterize possible association between the lipid composition of FF and the outcome of pregnancy, we carried out a lipidomics study and compared the abundance of lipids from FF of patients with positive and negative outcomes. We found a differential lipid network wiring in positive‐outcome FF, with a significant decrease (∼2 fold; P < 0.001) in triacylglycerol levels and higher accumulation (10–50%; P < 0.001) of membrane lipids groups (phospholipids and sphingolipids). In addition to this major metabolic alteration, other lipid groups such as cholesteryl esters showed lower levels in positive‐outcome patients, whereas derivatives of vitamin D were highly accumulated in positive‐outcome FF, supporting previous studies that associate vitamin D levels in FF to pregnancy outcome. Our data also point to specific lipid species with a differential accumulation pattern in positive‐outcome FF that predicted pregnancy in a receiver operating characteristic analysis. Altogether, our results suggest that FF lipid network is associated with the oocyte development, with possible implications in diagnostics and treatment.—Shehadeh, A., Bruck‐Haimson, R., Saidemberg, D., Zacharia. A., Herzberg, S., Ben‐Meir, A., Moussaieff, A. A shift in follicular fluid from triacylglycerols to membrane lipids is associated with positive pregnancy outcome. FASEB J. 33, 10291–10299 (2019). http://www.fasebj.org

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confidence: 96%

A shift in follicular fluid from triacylglycerols to membrane lipids is associated with positive pregnancy outcome

et al. 2019

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“…Furthermore, analyzing the networks built with the lipid list in FF, we noticed enhanced metabolism of glycerophospholipid, and pantothenate and CoA biosynthesis involved in the beta‐oxidation of fatty acids. This involvement can lead to incomplete oxidation with the accumulation of lipid metabolites with consequent lipotoxicity in the ovaries (Gonzalez, Lane, Knight, & Robker, 2018). Jungheim et al (2011) has noted that this induces the production of low‐quality oocytes during in vitro fertilization.…”

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confidence: 99%

Relationship between the metabolic and lipid profile in follicular fluid of women undergoing in vitro fertilization

Luti

Fiaschi

Magherini

et al. 2020

Molecular Reproduction Devel

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“…In bovine, TAGs are a primary energy source in the developing oocyte [ 39 ]. Nevertheless, a high TAG content in the FF was correlated to a reduced follicle size [ 19 ] and an increased expression of adipokines and proinflammatory cytokines in the FF [ 20 ]. It is therefore likely that local concentrations of TAGs are important for the development of the oocyte but are harmful in higher concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Triacylglycerol (TAGs) concentrations inversely correlated with the follicle size [ 19 ] and positively correlated to maternal BMI [ 6 , 18 ]. TAG accumulation in the FF were also correlated to the levels of adipokines and proinflammatory cytokines in FF [ 20 ], implying inflammatory processes in the FF that are caused by high TAG levels and may attenuate oocyte development. Several phosphocholines showed lower accumulation in poor ovarian responder patients [ 21 ].…”

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confidence: 99%

A Shift in Glycerolipid Metabolism Defines the Follicular Fluid of IVF Patients with Unexplained Infertility

et al. 2020

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Follicular fluid (FF) constitutes the microenvironment of the developing oocyte. We recently characterized its lipid composition and found lipid signatures of positive pregnancy outcome after in vitro fertilization (IVF). In the current study, we aimed to test the hypothesis that unexplained female infertility is related to lipid metabolism, given the lipid signature of positive-outcome IVF patients we previously found. Assuming that FF samples from IVF patients with male factor infertility can represent a non-hindered metabolic microenvironment, we compared them to FF taken from women with unexplained infertility. FF from patients undergoing IVF was examined for its lipid composition. We found highly increased triacylglycerol levels, with a lower abundance of monoacylglycerols, phospholipids and sphingolipids in the FF of patients with unexplained infertility. The alterations in the lipid class accumulation were independent of the body mass index (BMI) and were altogether kept across the age groups. Potential lipid biomarkers for pregnancy outcomes showed a highly discriminative abundance in the FF of unexplained infertility patients. Lipid abundance distinguished IVF patients with unrecognized infertility and provided a potential means for the evaluation of female fertility.

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Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index

Cited by 45 publications

References 61 publications

A shift in follicular fluid from triacylglycerols to membrane lipids is associated with positive pregnancy outcome

A shift in follicular fluid from triacylglycerols to membrane lipids is associated with positive pregnancy outcome

Relationship between the metabolic and lipid profile in follicular fluid of women undergoing in vitro fertilization

A Shift in Glycerolipid Metabolism Defines the Follicular Fluid of IVF Patients with Unexplained Infertility

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