Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study

Zhou, Tingfeng; Chen, Mengjiao; Zhang, Yuan; Xia, Zhigang; Zhang, Shurou; Zhang, Ziheng; Chen, Huanqi; Lin, Rongcheng

doi:10.3389/fneur.2023.1111255

Cited by 4 publications

(2 citation statements)

References 34 publications

(21 reference statements)

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“…These include anakinra (IL-1 inhibitor), canakinumab (IL-1 inhibitor), tocilizumab (IL-6 inhibitor), infliximab (TNF-alpha inhibitor), and rituximab (B-cell inhibitor), all of which have displayed efficacy. Intriguingly, Zhou et al presented a MR analysis ( 31 ) indicating that C-reactive protein is a risk factor for SSHL, while TNF-α and fibrinogen do not increase the risk for SSHL. Therefore, TNF-α, an inflammatory marker, exhibited elevated levels in SSHL, but without any relation to its progression.…”

Section: Discussionmentioning

confidence: 99%

Causal role of immune cell phenotypes in idiopathic sudden sensorineural hearing loss: a bi-directional Mendelian randomization study

Li,

Zhou,

Zhou

et al. 2024

Front. Neurol.

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BackgroundA growing body of evidence suggests that immunological processes have a significant role in developing idiopathic sudden sensorineural hearing loss (SSHL). However, few studies have examined the association between immune cell phenotype and SSHL using Mendelian Randomization (MR).MethodsThe online genome-wide association studies (GWAS) database was used to compile data from GWAS covering 731 immunophenotypes and SSHL. Inverse variance weighted (IVW) analysis was primarily used for MR study, and single nucleotide polymorphisms (SNPs) associated with immunophenotypes served as dependent variables. A sensitivity study and the false discovery rate (FDR) correction were used to examine the MR hypothesis. In addition, the possibility of reverse causality between immunophenotype and SSHL was validated by reverse MR. Reverse MR was analyzed in a manner consistent with forward MR.ResultsAfter FDR correction and sensitivity analysis, we screened 7 immunophenotypes, including IgD+ CD38dim %lymphocyte (95% CI: 1.0019, 1.0742, p = 3.87 × 10−2, FDR = 1.15 × 10−2); Unsw mem AC (95% CI: 1.004, 1.2522, p = 4.23 × 10−2, FDR = 2.25 × 10−2); CD86+ myeloid DC AC (95% CI: 1.0083, 1.1147, p = 2.24 × 10−2, FDR = 4.27 × 10−2); CD33dim HLA DR− AC (95% CI: 1.0046, 1.0583, p = 2.12 × 10−2, FDR = 4.69 × 10−2); SSC-A on CD8br (95% CI: 1.0028, 1.1461, p = 4.12 × 10−2, FDR = 4.71 × 10−2); CD45RA− CD4+ %T cell (95% CI: 1.0036, 1.0503, p = 2.32 × 10−2, FDR = 4.82 × 10−2); DP (CD4+CD8+) AC (95% CI: 1.011, 1.2091, p = 2.78 × 10−2, FDR = 4.97 × 10−2). There was a strong causal relationship with SSHL onset, and the reliability of the results was verified. Furthermore, the immunological cell profile and SSHL did not appear to be closely associated, as shown by reverse MR analysis.ConclusionOur study provides more support for the current hypothesis that immunophenotypes and the pathophysiology of SSHL are closely associated. Further validation is needed to assess the role of these immunophenotypes in SSHL.

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Section: Discussionmentioning

confidence: 99%

Causal role of immune cell phenotypes in idiopathic sudden sensorineural hearing loss: a bi-directional Mendelian randomization study

Li,

Zhou,

Zhou

et al. 2024

Front. Neurol.

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“…Twenty-two genetic studies were included. 5,7,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] These genetic studies sought to find genetic variants associated with the development of SSNHL and their results are summarized in Table IV.…”

Section: Genetic Studiesmentioning

confidence: 99%

A Systematic Review on Heritability of Sudden Sensorineural Hearing Loss

Yélamos Lorente,

Perez‐Carpena,

Lopez‐Escamez

2024

The Laryngoscope

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ObjectiveTo assess the evidence supporting the heritability and genetic basis of sudden sensorineural hearing loss (SSNHL).Data SourceRecords were extracted from PubMed, Scopus, and Cochrane databases.Review MethodsThe protocol was registered on PROSPERO (CRD42022357389) and includes a systematic review on the genetic contribution to SSNHL. The search strategy yielded 1.483 articles from electronic databases. After quality assessment, 34 records were selected, including 369.650 patients with SSNHL from nine prevalence studies, two familial aggregation studies, one twin study, and 22 genetic studies. The prevalence of SSNHL was calculated from data on its incidence from population‐based studies (period prevalence). To evaluate the heritability of SSNHL, the sibling recurrence risk ratio (λs) was calculated, by comparing the prevalence of SSNHL among siblings within the same generation to the estimated prevalence in the overall population. Genetic variants were grouped, based on the pathological mechanism related to SSNHL.ResultsThe prevalence of SSNHL ranged from 0.1% to 0.0003% in America to 0.12%–0.0093% in Asia. The estimated sibling recurrence risk ratio for SSNHL (λs = 20.8–83.3) supports a significant familial aggregation. Although several genetic variants were reported to be associated with SSHL in controlled studies, neither was replicated in an independent cohort.ConclusionsEvidence supporting heritability of SSNHL is limited to epidemiological studies showing prevalence differences across different populations and familial aggregation. Genetic studies are of low quality and they lack replication cohort to confirm their findings. According to its low prevalence, exome or genome sequencing familial‐based studies are needed to identify rare genetic variants in SSNHL.Level of EvidenceNA Laryngoscope, 2024

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Comparison of Batroxobin Versus the Combination of Batroxobin and Intratympanic Dexamethasone Injection in the Treatment of Sudden Sensorineural Hearing Loss

Jia,

Zhu,

et al. 2024

Ear Nose Throat J

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Introduction: Sudden sensorineural hearing loss (SSNHL) manifests as an abrupt decline in hearing by at least 30 dB within a 3 day period. Intratympanic dexamethasone injection (ITDI) has gained recognition as a potential treatment for SSNHL. This study aims to investigate the efficacy of combining batroxobin with ITDI (Bat and ITDI) in treating SSNHL patients and its influence on peripheral blood inflammatory indicators. Methods: SSNHL patients were retrospectively categorized into the control group (treated with Bat) and the observation group (treated with Bat and ITDI). The study involved analyzing clinical baseline data, evaluating clinical efficacy, and comparing the total effective rates among SSNHL patients with different audiometric curve types in the observation group. Routine blood tests were performed on peripheral blood samples to calculate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and to determine C-reactive protein (CRP) levels. Adverse reactions and complications were closely monitored. Results: Following treatment, both groups displayed improvements in hearing, with the observation group exhibiting a significantly higher total effective rate (75.90%) than the control group (59.78%). For patients with 3 distinct types of sudden hearing loss (high-frequency, flat-frequency, total deafness), Bat and ITDI treatment demonstrated increased total effective rate for patients with different sudden hearing loss types (high-frequency, flat-frequency, and total deafness). Both groups experienced reduced peripheral blood CRP levels and the NLR/PLR values, with the observation group demonstrating lower values. Additionally, across the 4 audio metric subtypes, the levels of peripheral blood CRP, NLR, and PLR decreased in SSNHL patients, and the observation group had a lower incidence of adverse reactions compared to the control group. Conclusions: Bat and ITDI emerge as notably more effective for SSNHL patients, displaying potential for reducing peripheral blood inflammatory indicator levels and mitigating the incidence of adverse reactions or complications, thereby enhancing safety.

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Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study

Cited by 4 publications

References 34 publications

Causal role of immune cell phenotypes in idiopathic sudden sensorineural hearing loss: a bi-directional Mendelian randomization study

Causal role of immune cell phenotypes in idiopathic sudden sensorineural hearing loss: a bi-directional Mendelian randomization study

A Systematic Review on Heritability of Sudden Sensorineural Hearing Loss

Comparison of Batroxobin Versus the Combination of Batroxobin and Intratympanic Dexamethasone Injection in the Treatment of Sudden Sensorineural Hearing Loss

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