2006
DOI: 10.1161/circulationaha.105.001032
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Abstract: Background-The inflammatory response triggered by cardiac surgery with cardiopulmonary bypass (CPB) is a primary mechanism in the pathogenesis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-patient variability poorly predicted by clinical and procedural factors. We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery. Methods and Results-We genotyped 48 polymorphisms from 23 candidate gen… Show more

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Cited by 102 publications
(107 citation statements)
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References 28 publications
(22 reference statements)
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“…malignant hyperthermia [14] or pseudocholinesterase deficiency [15]), anaesthetists are applying this line of thinking to study of the possible role of specific alleles in cardiovascular [16] and cerebral [17] outcomes after surgery, clotting postsurgery [18], renal function [19] and even less 'dramatic' issues such as the effectiveness of topical anaesthesia creams [20].…”
Section: Relevance For Clinical Anaesthesiamentioning
confidence: 99%
“…malignant hyperthermia [14] or pseudocholinesterase deficiency [15]), anaesthetists are applying this line of thinking to study of the possible role of specific alleles in cardiovascular [16] and cerebral [17] outcomes after surgery, clotting postsurgery [18], renal function [19] and even less 'dramatic' issues such as the effectiveness of topical anaesthesia creams [20].…”
Section: Relevance For Clinical Anaesthesiamentioning
confidence: 99%
“…The length of ischemia (in the case of cardiac surgery this is tracked as aortic cross-clamp time), is a clinical variable that predicts perioperative myocardial events [3] and therefore must be taken into account as a co-variate in analysis of this endpoint. Both myocardial ischemia and catecholamine-induced stress induce IL-6 and tissue factor (TF) production in patients with coronary artery disease [19], and decrease the PI3-kinase survival pathway [20].…”
Section: Perioperative Physiologymentioning
confidence: 99%
“…These studies should ideally focus on mechanistic pathways with carefully defined clinical endpoints and include all appropriate clinical covariates in order to optimize reproducibility of the final results. End-points examined thus far include bleeding, renal injury, stroke, neurocognitive deficits, myocardial injury, sepsis, and arrhythmias [3,58,61,63,69,[79][80][81]; analysis typically includes creation of clinical models, genetic models, and combined clinical/genetic models for these adverse outcomes, with careful adjustment for multiple comparisons. A recent invited review [2] introduced the concept of perioperative genomics to the broader cardiovascular community.…”
Section: Genetics and Adverse Perioperative Outcomesmentioning
confidence: 99%
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“…Perioperative complications, including acute kidney injury [6], postoperative bleeding [7], myocardial injury [8], and stroke [9], have been correlated with a variety of proinflammatory genotypes. The fact that a number of these genes (and/or gene products) identified in these association studies, such as the inflammatory mediators IL-6 and CRP as well as the endothelial adhesion molecules E-selectin and ICAM, have been previously implicated in the natural history of chronic inflammatory diseases provides proof of principle that this model is robust and can be extrapolated beyond the perioperative context.…”
Section: How Do We Study Patients In the Perioperative Period?mentioning
confidence: 99%