Inflammatory cell response to calcium phosphate biomaterial particles: An overview

Velard, Frédéric; Braux, Julien; Amédée, Joëlle; Laquerrière, Patrice

doi:10.1016/j.actbio.2012.09.035

Cited by 140 publications

(95 citation statements)

References 135 publications

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“…Due to poor vascularisation or low metabolic activity, the capacity of the surrounding tissue to eliminate the by-products may be low leading to a build up of the by-products thereby causing local temporary disturbances (97): A massive in vivo release of acidic degradation by-products leading to inflammatory reactions has been reported for several (120). It is also known that calcium phosphate biomaterial particles can cause inflammatory reactions after being implanted (although this inflammatory reaction may be considered desirable to a certain extent as it subsequently stimulates osteoprogenitor cell differentiation and bone matrix deposition) (123). These examples illustrate that potential problems related to biocompatibility in tissue engineering constructs for bone and cartilage applications may be related to the use of biodegradable, erodible and bioresorbable polymer scaffolds.…”

Section: Biocompatibilitymentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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Section: Biocompatibilitymentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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“…Besides, presence of calcium pyrophosphate impurity might be the reason of inflammation [670]. Additional details on inflammatory cell responses to CaPO 4 might be found in a special review on this topic [671].…”

Section: Interactions With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

Calcium orthophosphate bioceramics

Dorozhkin¹

2015

Ceramics International

206

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“…The fibrotic response to foreign bodies has significant downstream effects on the functionality of a biomaterial, particularly if the material is bioactive with regards to delivery of drugs or signaling molecules [4]. Fibrosis and inflammatory responses have also been shown to loosen implanted calcium phosphate-containing organic matrices used in bone regeneration [5]. The pre-existing inflammatory milieu in myocardial infarction, in addition to response to the scaffolds used in cardiac patches for assisted tissue regeneration can decrease the survival of cells within the engineered patch [6].…”

Section: Foreign Body Immune Responses In Tissue Engineeringmentioning

confidence: 99%

The promising role for adipose-derived mesenchymal stem cells in tissue regeneration

Arun¹,

Lee²,

Brandacher³

et al. 2016

Nanomaterials and Regenerative Medicine

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Inflammatory cell response to calcium phosphate biomaterial particles: An overview

Cited by 140 publications

References 135 publications

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Calcium orthophosphate bioceramics

The promising role for adipose-derived mesenchymal stem cells in tissue regeneration

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