2021
DOI: 10.3390/jcm10184214
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Abstract: Malnutrition is a major contributor to muscle loss and muscle dysfunction, known as sarcopenia. Malnutrition is common in patients with inflammatory bowel disease (IBD). IBD includes ulcerative colitis (UC) and Crohn’s disease (CD). The number of patients with IBD has recently been increasing. More severe malnutrition is often seen in CD compared to UC, probably due to CD affecting the main site of nutrient absorption, extensive mucosal lesions, fistulas, short bowel syndrome after resection, or obstruction of… Show more

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Cited by 28 publications
(32 citation statements)
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References 116 publications
(200 reference statements)
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“…In patients with IBD, sarcopenia may be caused by selfimposed food intake restrictions to prevent disease flare-ups, malabsorption, excessive loss of nutrients, or increased demand for nutrients (25). In this study, the prevalence of sarcopenia diagnosed according to the AWGS2019 criteria was 50.8% in 65 cases of suspected sarcopenia.…”
Section: Discussionmentioning
confidence: 72%
See 1 more Smart Citation
“…In patients with IBD, sarcopenia may be caused by selfimposed food intake restrictions to prevent disease flare-ups, malabsorption, excessive loss of nutrients, or increased demand for nutrients (25). In this study, the prevalence of sarcopenia diagnosed according to the AWGS2019 criteria was 50.8% in 65 cases of suspected sarcopenia.…”
Section: Discussionmentioning
confidence: 72%
“…Of those diagnosed with sarcopenia, 69.6% had poor outcomes. These results imply that sarcopenia is common among patients with IBD (25). Therefore, early screening, diagnosis, and intervention should be performed to improve the prognosis.…”
Section: Discussionmentioning
confidence: 95%
“…Additionally, the GLIM criteria consider muscle mass, which has been overlooked by the majority of criteria for evaluating malnutrition. A systematic review revealed that up to 60% of IBD patients exhibited skeletal muscle mass depletion ( 15 ), which correlated with the blockage of protein synthesis and absorption in patients ( 46 ). Interestingly, Adams et al ( 47 ) reported that more than 40% of patients affected by sarcopenia presented with a normal BMI, and that up to 20% were overweight or obese, which were not identified as undernourished by traditional measures.…”
Section: Discussionmentioning
confidence: 99%
“…In a Manitoba IBD cohort study, LM was the strongest determinant of BMD and its variation was associated with changes in bone density [62]. Sarcopenia is highly prevalent in IBD patients and can develop through a variety of mechanisms, including malnutrition, chronic inflammation, increased inflammatory status in adipose tissue, vitamin deficiency and imbalance of the muscle-gut axis [63]. Strategies to increase LM include, among other, physical exercise and this was recently shown to modulate the relationship between muscle and bone density in young people with IBD [64] As for the correlation between ASMI and TBS, the former was an independent positive predictor in young, healthy persons, regardless of gender [65].…”
Section: Discussionmentioning
confidence: 99%