Inflammatory Bowel Disease and Current Treatment Options in Dogs

Arslan, Handan Hilal

doi:10.3844/ajavsp.2017.150.158

Cited by 2 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastrointestinal conditions characterized by abdominal pain, vomiting, and diarrhea are common signs in dogs. Chronic enteropathies (CE) in dogs are a heterogenous group of gastrointestinal (GI) disorders characterized by clinical signs that persist for at least 3 weeks or longer when other intestinal conditions such as parasitism or neoplasia have been ruled out 1,2 . CE in dogs is perceived to be a common presentation in all types of veterinary clinics with a prevalence reaching 18% based on databases obtained from general veterinary practices and insurance 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

Estruch¹,

Johnson

Ford³

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Dogs with chronic enteropathies (CE) displayed elevated IgA seropositivity against specific markers that can be used to develop a novel test.Objective: To assess a multivariate test to aid diagnosis of CE in dogs and to monitor treatment-related responses.Animals: One hundred fifty-seven dogs with CE/inflammatory bowel disease (IBD), 24 dogs non-IBD gastrointestinal disorders, and 33 normal dogs.Methods: Prospective, multicenter, clinical study that enrolled dogs with gastrointestinal disorders. Serum sample collected at enrollment and up to 3 months follow-up measuring OmpC (ACA), canine calprotectin (ACNA), and gliadin-derived peptides (AGA) by ELISA.Results: Seropositivity was higher in CE/IBD than normal dogs (66% vs 9% for ACA; 55% vs 15% for ACNA; and 75% vs 6% for AGA; P < .001). When comparing CE/IBD with non-IBD disease, ACA and ACNA displayed discriminating properties (66%, 55% vs 12.5%, 29% respectively) while AGA separated CE from normal cohorts (54% vs 6%). A 3-marker algorithm at cutoff of ACA > 15, ACNA > 6, AGA > 60 differentiates CE/IBD and normal dogs with 90% sensitivity and 96% specificity; and CE/IBD and non-IBD dogs with 80% sensitivity and 86% specificity. Titers decreased after treatment (47%-99% in ACA, 13%-88% in ACNA, and 30%-85% in AGA), changes that were concurrent with clinical improvements. Conclusion and ClinicalImportance: An assay based on combined measurements of ACA, ACNA, and AGA is useful as a noninvasive diagnostic test to distinguish dogs with CE/IBD. The test also has the potential to monitor response to treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

Estruch¹,

Johnson

Ford³

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Incidence of IBD in the present study was found to be 0.1 per cent (33 dogs) out of 30,535 diseased dogs presented to the Small Animal Medicine Unit with various ailments. However, Arslan (2017) stated that there is no information about incidence for IBD in dogs and cats. This is because, characterisation of many cases remains incomplete and detailed histopathological criteria for the medical diagnosis are needed.…”

Section: Resultsmentioning

confidence: 99%

Clinical Signs, Activity Indices and Prognostic Indicators in Dogs with Idiopathic Inflammatory Bowel Disease

Bhavani

Kavitha

Vairamuthu

et al. 2021

IJAR

View full text Add to dashboard Cite

Background: Canine inflammatory bowel disease (IBD) includes a set of diseases characterized by the presence of recurrent gastrointestinal clinical signs and histologic evidence of intestinal inflammation. Diagnosis can only be made by excluding other possible causes of enteritis. Since the diagnosis of this disease is of great challenge to the veterinarians and currently very little work have been carried out in India, the present study was planned and conducted to study the clinicopathological changes and prognostic indicators of idiopathic inflammatory bowel disease (IBD) in dogs.Methods: After a detailed clinical, laboratoty and endoscopic examination, 33 IBD dogs with signs of chronic gastrointestinal disorders and histologic evidence of mucosal lymphocytic plasmacytic infiltration were selected for the study.Result: Moderate to severe form of IBD with haematochezia as a chief complaint was predominantly recorded. Haematobiochemical changes were not remarkable except a rise in serum alkaline phosphatase level. Decreased IgA expression was observed in serum by flowcytometry indicating impaired mucosal immunity in IBD dogs. It was observed that, increased clinical inflammatory bowel disease activity index score (CIBDAI), increased C-Reactive Protein, decreased cobalamin and folate may act as negative predictors in idiopathic IBD.

show abstract

Inflammatory Bowel Disease and Current Treatment Options in Dogs

Cited by 2 publications

References 41 publications

Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

Clinical Signs, Activity Indices and Prognostic Indicators in Dogs with Idiopathic Inflammatory Bowel Disease

Contact Info

Product

Resources

About