Inflammatory Biomarkers and Physical Function in Older, Obese Adults with Knee Pain and Self‐Reported Osteoarthritis After Intensive Weight‐Loss Therapy

Miller, Gary D.; Nicklas, Barbara J.; Loeser, Richard F.

doi:10.1111/j.1532-5415.2007.01636.x

Cited by 96 publications

(85 citation statements)

References 46 publications

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“…However, it is not uncommon to observe elevated concentrations, especially in those with mid-stage to severe osteoarthritis. High circulating levels of TNF-a and IL-6 tend to be associated with lower physical function and slower walking speed in the elderly with knee OA, 31,36 but in the present study, this was not the case. Because TNF-a plays such a pivot role in the conservation of OA and is associated with greater radiographic of knee occurrences, 35 1 week of treatment is unlikely a long enough duration to observe decreases, especially considering that many of the subjects were inactive prior to the 6MWT.…”

Section: Discussioncontrasting

confidence: 69%

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Arjmandi

Ormsbee

Elam

et al. 2014

Journal of Medicinal Food

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The extracts of Scutellaria baicalensis and Acacia catechu have been shown in previous studies to alleviate joint discomfort, reduce stiffness, and improve mobility by reducing the production of proinflammatory molecules over long periods of supplementation. The acute effects of intake of these extracts have not yet been investigated. Thus, we carried out a 1 week clinical trial to examine the extent to which UP446-a natural proprietary blend of S. baicalensis and A. catechu (UP446)-decreases knee joint pain, mobility, and biomarkers of inflammation in comparison to naproxen. Seventy-nine men and women (40-90 years old) diagnosed as having mild to moderate osteoarthritis (OA) consumed either 500 mg/day of the UP446 supplement or 440 mg/day of naproxen for 1 week in a double-blind randomized control trial. Pain, knee range of motion (ROM), and overall physical activity were evaluated at the start and at the end of treatment. Fasting blood was collected to determine serum interleukins 1b and 6, tumor necrosis factor-a, C-reactive protein, and hyaluronic acid. The UP446 group experienced a significant decrease in perceived pain (P = .009) time dependently. Stiffness was significantly reduced by both treatments (P = .002 UP446, P = .008 naproxen). Significant increases in mean ROM over time (P = .04) were found in the UP446 group. These findings suggest that UP446 is effective in reducing the physical symptoms associated with knee OA.

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Section: Discussioncontrasting

confidence: 69%

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Arjmandi

Ormsbee

Elam

et al. 2014

Journal of Medicinal Food

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“…30 However, no significant association found between CRP positivity and degree of knee pain and drug intake by patients. This contrasted other studies (Miller et al., 31 Marta et al…”

Section: Methodscontrasting

confidence: 55%

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Pirdawood¹,

Albarzinji

2017

ZJMS

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“…In addition to the several functional and morphological changes of the articular tissues, studies have shown altered inflammatory factors such as cytokines, including interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL-15, IL-17, and IL-1 [3,[5][6][7][8], chemokines [9,10], receptors [4,11], and proteases [12,13], mainly on the lesion focus, showing the multifactorial nature of the disease. Due to the technical difficulty and risk of obtaining the biological samples, studies have examined the behavior of these inflammatory factors in the blood [10,14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise

et al. 2012

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The aim of this study was to evaluate levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and soluble forms of the TNF-α receptor (sTNFR1 and sTNFR2) from plasma taken from the peripheral blood of elderly individuals presenting with osteoarthritis (OA) of the knee. These patients underwent aerobic treatment through the use of physical exercises. The study consisted of a longitudinal analysis of older individuals presenting clinical and radiographic diagnosis of knee OA that were submitted to 12 weeks of aerobic treatment. The individuals were evaluated during acute exercise or after chronic exercise. During acute exercise (walking slowly on the mat), blood samples of the patients were collected before, immediately after, and 30 min following the end of training. After chronic exercise (aerobic walking training, three times/week for 12 weeks), patient blood samples were obtained for comparison. Additionally, clinical and functional assessments (WOMAC test and 6-min walk) were performed at the end of all physical exercises. Plasma concentrations of cytokines and soluble receptors were measured by ELISA. Aerobic training increased the plasma concentration of sTNR1; however, it decreased the plasma concentration of sTNFR2, when compared with levels of resting patients. Acute exercise differentially affects the levels of sTNFR1 dependent on when the samples were taken, before and after aerobic training. However, the levels of sTNFR2 were not affected by training. For the population studied, we observed differences in the levels of sTNFR1 and sTNFR2 following acute and chronic exercise. Other additional factors, like the level of inactivity of the individual and the type of physical exercise that patients are exposed to, need to be considered as well. The variation in the levels of soluble receptors correlated with functional improvement; however, the inflammatory osteoarthritis markers (IL-6 and TNF-α) were unaffected by the walking exercises.

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Inflammatory Biomarkers and Physical Function in Older, Obese Adults with Knee Pain and Self‐Reported Osteoarthritis After Intensive Weight‐Loss Therapy

Abstract: These results indicate that an intensive weight-loss intervention in older obese adults with knee pain can help improve inflammatory biomarkers and that changes in these concentrations showed associations with physical function.

Cited by 96 publications

References 46 publications

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise

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