2021
DOI: 10.1177/15357597211040939
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Abstract: Viral infection of the central nervous system increasingly places people at risk of developing life-threatening and treatment-resistant acute and chronic seizures (epilepsy). The emergence of new human viruses due to ongoing social, political, and ecological changes places people at risk more than ever before. The development of new preventative or curative strategies is critical to address this burden. However, our understanding of the complex relationship between viruses and the brain has been hindered by th… Show more

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Cited by 3 publications
(7 citation statements)
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“…It is also important to note that the consequences of pharmacological vs. genetic manipulation of monocyte invasion and microglia activation strikingly differed ( Table 3 ). Furthermore, the interplay between microglia and invading monocytes in this model is more complex than previously proposed by other groups ( Libbey and Fujinami, 2011 ; DePaula-Silva et al, 2017 , 2018 , 2021 ).…”
Section: The Theiler’s Murine Encephalomyelitis Virus Mouse Model To ...mentioning
confidence: 80%
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“…It is also important to note that the consequences of pharmacological vs. genetic manipulation of monocyte invasion and microglia activation strikingly differed ( Table 3 ). Furthermore, the interplay between microglia and invading monocytes in this model is more complex than previously proposed by other groups ( Libbey and Fujinami, 2011 ; DePaula-Silva et al, 2017 , 2018 , 2021 ).…”
Section: The Theiler’s Murine Encephalomyelitis Virus Mouse Model To ...mentioning
confidence: 80%
“…Upon viral invasion of the CNS, activation of the innate and adaptive immune response is critical to control viral replication and spread ( Libbey and Fujinami, 2014 ; Figure 3 ). However, an exuberant innate response to the infection may cause considerable acute bystander pathology, while failing to adequately control viral replication which may lead to persistent smoldering inflammation that results in chronic neuropathology ( DePaula-Silva et al, 2021 ; Figure 3 ). In general, as illustrated in Figure 5 , inflammation plays a prominent role in the mechanisms underlying increased neuronal excitability in both early and late seizures associated with virus infection ( Vezzani et al, 2016 ).…”
Section: Mechanisms Of Seizures and Epilepsy Associated With Viral In...mentioning
confidence: 99%
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