Inflammation or infection at the time of second trimester induced abortion

Roncari, Danielle; Politch, Joseph A.; Sonalkar, Sarita; Finneseth, Molly; Borgatta, Lynn

doi:10.1016/j.contraception.2012.09.016

Cited by 9 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spontaneous labour might have started before the digoxin injection. Digoxin might induce prostaglandin release that can stimulate cervical ripening, as one study reported inflammatory responses 24 hours after intra‐amniotic digoxin injection for TOP at 19–23 weeks of gestation . We considered that these factors contributed to the spontaneous fetal expulsion after digoxin injection.…”

Section: Discussionmentioning

confidence: 99%

Intra‐amniotic digoxin for feticide between 21 and 30 weeks of gestation: a prospective study

Sharvit

Klein

Silber

et al. 2019

BJOG

View full text Add to dashboard Cite

Objective Intra‐amniotic injection of digoxin is a well‐known method for feticide before inducing a termination of pregnancy (TOP) at 17–24 weeks of gestation. Information on its effectiveness when administered after 24 weeks of gestation is limited. This study evaluated the efficacy of intra‐amniotic digoxin injection for inducing fetal demise within 18–24 hours, at 21–30 weeks of gestation, and its safety. Design Prospective cohort study. Setting Tertiary university medical centre. Population Women at 21–30 weeks of gestation with a singleton pregnancy, admitted for TOP. Methods Intra‐amniotic injection of 2 mg of digoxin was performed 1 day before medical TOP. Fetal heart activity was evaluated by ultrasound for 18–24 hours after the injection. Serum digoxin level and maternal electrocardiogram (ECG) were evaluated 6, 10, and 20 hours after injection. Main outcome measure Frequency of successful fetal demise. Results Fifty‐nine women participated in the study. The mean gestational age was 24+2 weeks (range 21+0–30+0), with 29 (49.2%) beyond 24+0 weeks of gestation. Fetal cardiac activity arrest was achieved in 55/59 cases (93.2%). Normal maternal ECG recordings were noted in all cases. Mean serum digoxin levels 6 and 10 hours after injection were in the therapeutic range (1.3 ± 0.7 ng/l and 1.24 ± 0.49 ng/l, respectively) and below the toxic level (2 ng/l). Extramural delivery following digoxin did not occur. There were no cases of chorioamnionitis. Conclusion Intra‐amniotic digoxin for feticide at 21–30 weeks of gestation in a singleton pregnancy appears effective and safe before TOP at advanced gestational ages. Tweetable abstract This study shows that feticide by intra‐amniotic digoxin injection at 21–30 weeks of gestation appears effective and safe.

show abstract

Section: Discussionmentioning

confidence: 99%

Intra‐amniotic digoxin for feticide between 21 and 30 weeks of gestation: a prospective study

Sharvit

Klein

Silber

et al. 2019

BJOG

View full text Add to dashboard Cite

show abstract

“…IFN-γ, TNF, IL-6, and IL-8 levels were significantly increased in COVID-19 patients ( Huang et al., 2020 ), causing pregnant women with COVID-19 to be more prone to miscarriage and premature rupture of membranes. The secretion of TNF-α, IL-8, and IL-6 by macrophages in the process of inflammation can lead to abortion, premature rupture of membranes, and preterm labor ( Lee S. Y. et al., 2011 ; Roncari et al., 2013 ; Li et al., 2015 ; Li et al., 2020 ).…”

Section: Adverse Pregnancy Outcomes Due To Covid-19mentioning

confidence: 99%

“…SARS-CoV-2 not only binds to ACE2 but also causes it to be downregulated, so Ang 1-7) also decreases ( Glowacka et al., 2010 ). Preeclampsia is associated with reduced plasma Ang 1-7) levels in the mother ( Roncari et al., 2013 ). COVID-19 increases the risk of preeclampsia in pregnant women.…”

Section: Adverse Pregnancy Outcomes Due To Covid-19mentioning

confidence: 99%

Interactions Between Specific Immune Status of Pregnant Women and SARS-CoV-2 Infection

Chen

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the Coronavirus Disease 2019 (COVID-19) global pandemic. Because it is a new and highly contagious coronavirus, most people, especially pregnant women, lack immunity. It is therefore important to understand the interaction between why pregnant women are susceptible to SARS-CoV-2 and the specific immune systems of pregnant women. Here, we provide an overview of the changes that occur in the immune system during pregnancy, the activation and response of the immune system in pregnant women with COVID-19, adverse pregnancy outcomes in pregnant women with COVID-19, and the treatment and prevention of COVID-19 in this population.

show abstract

Expression of TLR4 and its effect on Treg cells in early pregnancy decidual stromal cells after lipopolysaccharide treating

Liu

Liu³

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Inflammation or infection at the time of second trimester induced abortion

Cited by 9 publications

References 17 publications

Intra‐amniotic digoxin for feticide between 21 and 30 weeks of gestation: a prospective study

Intra‐amniotic digoxin for feticide between 21 and 30 weeks of gestation: a prospective study

Interactions Between Specific Immune Status of Pregnant Women and SARS-CoV-2 Infection

Expression of TLR4 and its effect on Treg cells in early pregnancy decidual stromal cells after lipopolysaccharide treating

Contact Info

Product

Resources

About