Inflammation of Actinic Keratoses During Capecitabine Therapy

Exudative, Nonhealing Scalp: A Complication of Systemic Chemotherapy With Capecitabine and Bevacizumab

“…[1][2][3] The findings in our patient strengthen this association. 1 Recent data suggest squamous neoplasms are induced by sorafenib.…”

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factor receptor ␤, c-kit, and RAF, among other kinases. 1 The inflammation manifests primarily as simple erythema in areas of actinic keratoses, although acral erythema and other cutaneous adverse effects have been reported. Multiple eruptive keratoacanthomas (KAs), SCCs, and KA-type SCCs have been associated with sorafenib in several case reports and series.

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Chemotherapeutic agents and the skin: An update

“…Chemotherapy-induced inflammation of actinic keratoses was first described in 1962 with the use of systemic fluorouracil, but had never before been linked to capecitabine therapy. 217 Other capecitabine-induced cutaneous adverse events described in single case reports include cutaneous and mucosal hyperpigmentation, spotty, ''leopard-like'' repigmentation of vitiligo in sunexposed sites, 218 radiation recall dermatitis, onycholysis, and onychomadesis. 210,219 Tegafur…”

Oral capecitabine plus subcutaneous interferon alpha in advanced squamous cell carcinoma of the skin

“…The lower dosages used in the previous study did not cause severe adverse effects. Recently, an inflammation of actinic keratoses, potential SCC precursors, during capecitabine therapy has been reported [10].…”