Inflammation and iron status in bariatric surgery candidates

Careaga, M; Moizé, Violeta; Flores, Lílliam; Deulofeu, R.; Andreu, Alba; Vidal, Josep

doi:10.1016/j.soard.2014.09.028

Cited by 31 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Iron excess and inflammatory states stimulate hepcidin production by the liver, which blocks iron absorption into the circulation via ferroportin degradation and inhibits iron release from storage . This process of iron metabolism plays a major role in the development, diagnosis, and management of iron deficiency anemia …”

Section: Introductionmentioning

confidence: 99%

The role of iron repletion in adult iron deficiency anemia and other diseases

Elstrott

Khan

Olson

et al. 2019

European J of Haematology

102

View full text Add to dashboard Cite

Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide. The clinical management of patients with IDA requires a comprehensive understanding of the many etiologies that can lead to iron deficiency including pregnancy, blood loss, renal disease, heavy menstrual bleeding, inflammatory bowel disease, bariatric surgery, or extremely rare genetic disorders. The treatment landscape for many causes of IDA is currently shifting toward more abundant use of intravenous (IV) iron due to its effectiveness and improved formulations that decrease the likelihood of adverse effects. IV iron has found applications beyond treatment of IDA, and there is accruing data about its efficacy in patients with heart failure, restless leg syndrome, fatigue, and prevention of acute mountain sickness. This review provides a framework to diagnose, manage, and treat patients presenting with IDA and discusses other conditions that benefit from iron supplementation.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of iron repletion in adult iron deficiency anemia and other diseases

Elstrott

Khan

Olson

et al. 2019

European J of Haematology

102

View full text Add to dashboard Cite

show abstract

“…1,2 ID with or without anemia is amongst the most commonly reported nutritional deficiencies in patients undergoing bariatric surgery (BS). 3 ID may worsen the burden of obesity and complicate weight management. Fatigue, depression and reduced exercise capacity associated with ID may reduce the efficacy of behavioral weight management treatments.…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency and Obesity – Are we Diagnosing with Appropriate Indicators?

Monteiro¹,

Fernandes²,

Matta-Coelho³

et al. 2018

Acta Med Port

View full text Add to dashboard Cite

Introduction: We aim to define the iron deficiency prevalence and eventual differences between obese patients with and without metabolic syndrome. Material and Methods: Analysis of patients evaluated at multidisciplinary consultation of obesity in our institution between 2013 and 2015 (n = 260). Iron deficiency: ferritin levels < 15 ng/mL. Exclusion criteria: prior bariatric surgery; lack of ferritin or hemoglobin determinations. Results: We analyzed data from 215 patients (84.2% female) with a mean age of 42.0 ± 10.3 years. The median body mass index was 42.5 (40.0 -46.8) kg/m 2 and 52.1% had metabolic syndrome. Iron deficiency was present in 7.0%, with no differences between genders or between patients with or without metabolic syndrome. Hypertension was associated with lower prevalence of iron deficiency. Type 2 diabetes and hypertension patients had higher levels of ferritin. The multivariate analysis showed that metabolic syndrome and increasing body mass index were predictive of higher risk of iron deficiency while hypertension predicted lower odds of iron deficiency. Discussion: The prevalence of iron deficiency was similar in other published studies. Iron deficiency may be underdiagnosed if based only on ferritin concentrations. In our study, diabetes and hypertension appear to contribute to the increase in ferritin levels described in obesity. Conclusion: Ferritin may not be a reliable index for evaluating iron stores in obese patients, particularly when associated with comorbidities such as type 2 diabetes and hypertension. Further studies are needed to guide the diagnosis and iron supplementation in these patients.

show abstract

“…Functional iron deficiency is defined as inappropriately low iron stores, despite the presence of inflammation, i.e. a normal serum ferritin (12–100 ng/mL for females or 15–100 ng/mL for males) and a serum C-reactive protein >3 mg/L [6][7] A recent cross-sectional study of 947 obese patients under evaluation for bariatric surgery revealed that 52.5% exhibited functional iron deficiency. The majority of obese patients with functional iron deficiency appear to have sequestration of iron as manifest by a serum transferrin saturation <20% [6].…”

Section: Epidemiologymentioning

confidence: 99%

“…a normal serum ferritin (12–100 ng/mL for females or 15–100 ng/mL for males) and a serum C-reactive protein >3 mg/L [6][7] A recent cross-sectional study of 947 obese patients under evaluation for bariatric surgery revealed that 52.5% exhibited functional iron deficiency. The majority of obese patients with functional iron deficiency appear to have sequestration of iron as manifest by a serum transferrin saturation <20% [6]. Weight loss has been associated with an increase in transferrin saturation in overweight individuals [8], which supports the hypothesis that obesity causes iron sequestration.…”

Section: Epidemiologymentioning

confidence: 99%

Anemia of Inflammation

Fraenkel

2017

Medical Clinics of North America

160

105

View full text Add to dashboard Cite

Impaired iron homeostasis and the suppressive effects of proinflammatory cytokines on erythropoiesis, together with alterations of the erythrocyte membrane that impair its survival, cause the anemia of inflammation. Recent epidemiologic studies have connected inflammatory anemia with critical illness, obesity, aging, and kidney failure, as well as with cancer, chronic infection, and autoimmune disease. The proinflammatory cytokine, interleukin-6, the iron regulatory hormone, hepcidin, and the iron exporter, ferroportin, interact to cause iron sequestration in the setting of inflammation. While severe anemia is associated with adverse outcomes in critical illness, experimental models suggest that iron sequestration is part of a natural defense against pathogens. In animal models and human patients, experimental therapeutic approaches targeting interleukin-6 or the ferroportin-hepcidin axis have shown efficacy in reversing anemia, although these agents have not yet been approved for the treatment of the anemia of inflammation.

show abstract

Inflammation and iron status in bariatric surgery candidates

Cited by 31 publications

References 23 publications

The role of iron repletion in adult iron deficiency anemia and other diseases

The role of iron repletion in adult iron deficiency anemia and other diseases

Iron Deficiency and Obesity – Are we Diagnosing with Appropriate Indicators?

Anemia of Inflammation

Contact Info

Product

Resources

About