Inflammation and Congenital Heart Disease Associated Pulmonary Hypertension

Abstract

Preoperative inflammation markers may be correlated with the progression of pulmonary hypertensive disease, but further studies with larger sample size are needed to determine the predictive role of these markers for postoperative outcomes.

Does preoperative neutrophil-lymphocyte ratio indicate postoperative morbidity after repair of tetralogy of Fallot?

“…This can be explained by the fact that our study was lack of mortality, which was estimated to develop at higher pNLRs as in adult cohorts. [3][4][5] In contrary to Gürsoy et al, [8] although the pNLR in the current series was approximate to the Gürsoy et al's cohort, it was probably not high enough for the development of morbidity in our cohort. This circumstance may be a reflection of the retrospective design of the study and extensive implementation of the exclusion criteria leading to a sterile patient cohort in which 142 patients with predisposing risk factors for morbidity were excluded.…”

“…[1,2] The pNLR has been investigated in cardiovascular diseases in search of a powerful predictor of outcome. [3][4][5][6][7][8] However, as the pNLR has not been extensively evaluated in cyanotic pediatric cardiac surgery cases, we investigated whether the pNLR could predict postoperative morbidity in TOF in whom complete repair was performed.…”

“…Gürsoy et al [8] have recently evaluated the correlation of pNLR and CRP values with pulmonary artery pressure in 201 pediatric cardiac surgery cases. In his series, the mean pNLR and CRP were 0.82 and 0.23, respectively.…”

“…[1,2] Recently, preoperative neutrophil-lymphocyte ratio (pNLR) which has been suggested as an indicator of inflammatory status has come into view in cardiovascular diseases as a powerful predictor of outcome. [3][4][5][6][7][8] To the best of our knowledge, although pNLR has been suggested as a valuable predictor of mortality in adults. [3][4][5][6][7] the literature is scarce in regard to the predictive value of pNLR on morbidity in a cyanotic pediatric cardiac surgery cohort.…”

Biomarker and shear stress in secondary pediatric pulmonary hypertension

“…Elevated levels of CRP can be used to distinguish individuals with increased cardiovascular morbidity and mortality among apparently healthy subjects, patients with coronary artery disease, or those with atherosclerosis (19)(20)(21). It was found that serum concentrations of highly sensitive CRP positively correlated with pulmonary artery pressures in children with cystic fibrosis (22).…”